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Robotic Surgery Expert Dr. David Samadi, MD Discusses FDA Warnings on the Effect of GnRH Agonists
Date:10/27/2010

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The medical journal Circulation reported in February that various doctors' groups felt androgen deprivation hormone treatment for prostate cancer was believed to increase the risk of heart attack in patients with a prostate cancer diagnosis. Subsequent studies reported by the FDA determined a small increased risk of diabetes or heart disease in patients treated with these drugs. "Prostate cancer patients do not have to stop taking the drugs, but they go to their doctors with any concerns," said Dr. Samadi, "Patients should tell their doctors if they have ever had diabetes, heart disease, heart attack, stroke, history of high blood pressure, high cholesterol or if they are smokers."

All of these medicines for prostate cancer are allowed to remain on the market but must carry new label warnings. The drug manufacturers are currently reviewing the FDA request. "What's important to note is that hormone treatment for prostate cancer is not a fail-safe cure, because even though the therapy can extend survival, the prostate cancer tumors can eventually become immune to therapy," explained Dr. Samadi. Evidence has shown that lowering testosterone is an effective prostate cancer treatment, however lower testosterone levels can induce metabolic syndrome, which contributes to the development of heart disease. Men diagnosed with advanced prostate cancer who are on hormone therapy are at a twofold risk of developing metabolic syndrome.

"I routinely counsel my prostate cancer patients on the risks of weight gain and increased carbohydrate intake and advise them to eat sensibly and exercise in order to reduce their risk of developing metabolic syndrome," said Dr. Samadi, "These GnRH agonists might increase heart disease risks because they cause men to pack on extra weight, and, as usual, appropriate lifestyle choices are the best course of action in preventing prostate cancer or other disease."

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SOURCE www.Smart-Surgery.com
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