Navigation Links
Robotic Surgery Expert Dr. David Samadi, MD Discusses FDA Warnings on the Effect of GnRH Agonists

NEW YORK, Oct. 27 /PRNewswire/ -- Drugs, known as gonadotropin-releasing hormone (GnRH) agonists, may raise diabetes and heart risk and, as a result, now need new warnings. U.S. health officials said the drug used to stem the production of testosterone, the hormone that contributes to prostate cancer growth, could also lead to sudden death. "The risk of diabetes, heart disease and sudden death in men undergoing prostate cancer treatment with these drugs does not appear to be elevated, however patients should be regularly monitored by their doctors for signs of blood sugar increase or heart damage," said Dr. David Samadi, a robotic prostatectomy expert as well as the new Vice Chairman, Department of Urology, and Chief of Robotics and Minimally Invasive Surgery at The Mount Sinai Medical Center in New York City.



"Doctors need to monitor a prostate cancer patient's risk for diabetes and heart disease before starting any treatment and compare the side effects versus benefits," said Dr. Samadi, a urologic oncologist skilled in robotic prostate surgery. GnRH agonists are approved by the Food and Drug Administration to alleviate symptoms of advanced prostate cancer with androgen deprivation therapy treatment. These include Abbott's Lupron, AstraZeneca's Zoladex, Sanofi's Eligard, Watson Pharmaceuticals' Trelstar, Endo Pharmaceuticals' Vantas, Alza's Viadur, Pfizer's Synarel and several generic versions.

The medical journal Circulation reported in February that various doctors' groups felt androgen deprivation hormone treatment for prostate cancer was believed to increase the risk of heart attack in patients with a prostate cancer diagnosis. Subsequent studies reported by the FDA determined a small increased risk of diabetes or heart disease in patients treated with these drugs. "Prostate cancer patients do not have to stop taking the drugs, but they go to their doctors with any concerns," said Dr. Samadi, "Patients should tell their doctors if they have ever had diabetes, heart disease, heart attack, stroke, history of high blood pressure, high cholesterol or if they are smokers."

All of these medicines for prostate cancer are allowed to remain on the market but must carry new label warnings. The drug manufacturers are currently reviewing the FDA request. "What's important to note is that hormone treatment for prostate cancer is not a fail-safe cure, because even though the therapy can extend survival, the prostate cancer tumors can eventually become immune to therapy," explained Dr. Samadi. Evidence has shown that lowering testosterone is an effective prostate cancer treatment, however lower testosterone levels can induce metabolic syndrome, which contributes to the development of heart disease. Men diagnosed with advanced prostate cancer who are on hormone therapy are at a twofold risk of developing metabolic syndrome.

"I routinely counsel my prostate cancer patients on the risks of weight gain and increased carbohydrate intake and advise them to eat sensibly and exercise in order to reduce their risk of developing metabolic syndrome," said Dr. Samadi, "These GnRH agonists might increase heart disease risks because they cause men to pack on extra weight, and, as usual, appropriate lifestyle choices are the best course of action in preventing prostate cancer or other disease."

GnRH agonists are routinely used in conjunction with radiation therapy, which is why Dr. Samadi advocates the use of robotic prostatectomy over radiation. "It's the only treatment that completely removes the cancerous prostate gland without the need for hormones or radiation, and allows me to determine its stage, level and grade accurately," explained Samadi, "What's the point in preventing these patients from dying of prostate cancer if they are just going to die from heart disease? It makes no sense."Contact:  Dr. David B. Samadi  1-888-762-6810

Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. Cardicas Automated Anastomosis Systems Featured at Advances In Robotic And Hybrid Coronary Revascularization Meeting
2. Upstate New York Laboratory Robotics Interest Group (LRIG) to Host Free Symposium and Exhibition
3. Robotic Prostatectomy Expert Dr. David Samadi, MD Discusses Prostate Cancer Treatment Drug Abiraterone
4. Health Robotics Expands Operations Into Bosnia, Croatia, Finland, Macedonia, Montenegro, Serbia, and Slovenia
5. 100,000th Patient Treated With Accurays CyberKnife® Robotic Radiosurgery System
6. With Over 3,000 Robotic Prostatectomy Surgeries to His Credit, Dr. David Samadi, MD Discusses SMART Surgery and How it Improves Sexual and Urinary Function
7. International Robotic Urology Symposium 2011
8. Health Robotics Continues Worldwide Distribution Channel Expansion in Bulgaria, Czech Republic, Romania and Slovakia
9. Robotic Prostatectomy Expert Dr. David Samadi, MD Introduces His SMART Surgery Website for Prostate Cancer Treatment Education
10. Robotic Prostatectomy Expert Dr. David Samadi, MD Talks About Prostate Cancer Treatment News and Developments
11. Robotic Surgery Expert Dr. David B. Samadi, MD Discusses New Evidence That Proves The Low Complication Rates of Robotic Prostatectomy
Post Your Comments:
(Date:11/26/2015)... Nov. 26, 2015 Research and Markets ... the "2016 Future Horizons and Growth Strategies ... Supplier Shares, Country Segment Forecasts, Competitive Intelligence, Emerging ... --> --> This ... the Italian therapeutic drug monitoring market, including emerging ...
(Date:11/25/2015)... Nov. 26, 2015  The total global healthcare industry is ... 2015-2016. Latin America has the highest ... (excluding Japan ), is second with growth ... to face increased healthcare expenditure. In 2013-2014, total government funded ... 43.5% in 2008-2009 to 41.2% in 2013-2014. In real terms, ...
(Date:11/25/2015)... Nov. 25, 2015 AAIPharma Services Corp./Cambridge ... of at least $15.8  Million to expand its ... NC . The expansion will provide additional ... the growing demands of the pharmaceutical and biotechnology ... expansion will provide up to 40,000 square feet ...
Breaking Medicine Technology:
(Date:11/27/2015)... ... November 27, 2015 , ... An ... way to dispense prescription medications at home, so he invented the patent-pending ELECTRONIC ... and dispense prescription medications. In doing so, it could help to prevent potential ...
(Date:11/27/2015)... (PRWEB) , ... November 27, 2015 , ... ProSidebar: ... in Final Cut Pro X. With ProSidebar: Fasion, video editors can easily add ... ProSidebar as a minimalist title opener. Utilize presets featuring self-animating drop zones, lines, ...
(Date:11/27/2015)... ... , ... A simply groundbreaking television series, "Voices in America", which is hosted ... array of issues that are presently affecting Americans. Dedicated to providing the world with ... changing the subjects consumers focus on, one episode at a time. , In ...
(Date:11/27/2015)... IL (PRWEB) , ... November 27, 2015 , ... ... of the largest, most successful and prominent nonprofit healthcare organizations in the country. ... governance involvement with various organizations, and helped advance the healthcare industry as a ...
(Date:11/26/2015)... ... November 26, 2015 , ... Patients at Serenity ... have come together on Thanksgiving Day to share the things that they are ... the Serenity Point YouTube channel, patients displayed what they wrote on index cards, ...
Breaking Medicine News(10 mins):