Navigation Links
Rigel's R788 Significantly Improves Rheumatoid Arthritis in Phase 2b Clinical Trial
Date:7/9/2009

BP if had Adjustment or Initiation of BP Medication (mmHg) # Had BP Meds Adjusted/Initiated 11 (7%) 27 (18%) 35 (23%) BP Measurement Pre-Adjustment/Initiation 139 149 153 At Month 6 136 128 138 Mean Change -4 -20 -16

Study Design

TASKi2 was a 6 month, multi-center, randomized, double blind, placebo controlled, parallel dose clinical trial involving 457 RA patients in the U.S., Latin America and Europe who had failed to respond to methotrexate alone. The patients were randomly assigned to two cohorts and thus received R788 orally in either 100 mg bid (twice daily) or 150 mg qd (once daily) doses or placebo for a period of 6 months. Within in each cohort, patients were assigned on a 2:1 basis to R788 or placebo. All of the patients continued to receive their same stable dose of methotrexate throughout the clinical trial period.

Efficacy assessments for each participant were based on the American College of Rheumatology criteria, which denotes at least a 20% (ACR 20) improvement, at least a 50% (ACR 50) improvement, or at least a 70% (ACR 70) improvement, from the baseline assessment at the end of the 6 month treatment period. The ACR measurement factors include reported physician and patient global assessment of disease activity, patient reported pain score, and any change in C-reactive protein (CRP) in the patients' blood. The primary efficacy endpoint for the study was the percent of patients assigned to the R788 100 mg bid dose who were ACR 20 responders at the end of 6 months. Secondary efficacy endpoints included a comparison of response rates for the R788 100 mg bid and R788 150 mg qd doses at the ACR 20, ACR 50 and ACR 70 scores, as well as Disease Activity Scores (DAS) over the period of 6 months.


'/>"/>
SOURCE Rigel Pharmaceuticals, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Study Suggests High-Dose Fish Oil May Significantly Improve Behavior in Children with ADHD
2. DEFLUX(R) Significantly Reduces Urinary Tract Infections in Children With Vesicoureteral Reflux
3. Vidaza Significantly Extends Overall Survival by 74% in Phase 3 Trial in Myelodysplastic Syndromes (MDS)
4. Nexavar Significantly Improved Overall Survival in Phase 3 Asia-Pacific Liver Cancer Trial
5. Study Shows Vasopressin Receptor Antagonist VAPRISOL(R) (Conivaptan Hydrochloride Injection) Significantly Increased Serum Sodium Concentration in Patients with Euvolemic & Hypervolemic Hyponatremia
6. New Data Reveal Topical Divigel(R) (estradiol gel) 0.1% Significantly Reduces Frequency and Severity of Hot Flashes
7. Promising Phase 3 Trial Results Show Novel Biologic Therapy Ustekinumab (CNTO 1275) Significantly Improved Psoriasis
8. INVEGA(TM) Significantly Reduced Symptoms of Schizophrenia Compared to SEROQUEL(R) in Acutely Ill, Hospitalized Patients
9. New Data Published in Neurology Show Once-Daily Lamictal XR Significantly Reduced Partial Seizures in Patients with Epilepsy
10. Anesiva Announces Pivotal Phase 3 Trial of Zingo(TM) Meets Primary Endpoint and Significantly Reduces Venous Access Pain in Adults
11. A Sociolinguistic Analysis of In-Office Dialogue Reveals Psychiatrists and Parents Have Significantly Different Perceptions on ADHD and Psychiatric Comorbidities
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2015)... 31, 2015  The departments of Drug and Alcohol ... Gaudenzia Concept 90 to raise awareness for International Overdose ... Pennsylvania and help more Pennsylvanians ... recovery through the Building Bridges to Recovery ... every day to a disease that is fully treatable, ...
(Date:8/31/2015)... Mich. , Aug. 31, 2015  Diplomat Pharmacy, Inc. ... has announced that Phil Hagerman , Chairman & CEO, ... upcoming investor conferences. Mr. Hagerman and Mr. ... Healthcare Conference in Boston on Wednesday, ... Hagerman and Mr. Whelan are also scheduled to participate in ...
(Date:8/31/2015)... Soligenix, Inc. (OTCQB: SNGX) (Soligenix or ... that address unmet medical needs in the areas ... has completed enrollment of the additional subjects, as ... this year, into the company,s Phase 2 study ... regulator (IDR) and is being evaluated as a ...
Breaking Medicine Technology:Pennsylvania Departments of Drug & Alcohol Programs and Health Kick-off Second Annual Building Bridges to Recovery Initiative 2Diplomat to Participate in Upcoming Investor Conferences 2Soligenix Announces Completion of Patient Enrollment into its Phase 2 Clinical Trial of SGX942 for the Treatment of Oral Mucositis in Head and Neck Cancer Patients 2Soligenix Announces Completion of Patient Enrollment into its Phase 2 Clinical Trial of SGX942 for the Treatment of Oral Mucositis in Head and Neck Cancer Patients 3Soligenix Announces Completion of Patient Enrollment into its Phase 2 Clinical Trial of SGX942 for the Treatment of Oral Mucositis in Head and Neck Cancer Patients 4Soligenix Announces Completion of Patient Enrollment into its Phase 2 Clinical Trial of SGX942 for the Treatment of Oral Mucositis in Head and Neck Cancer Patients 5Soligenix Announces Completion of Patient Enrollment into its Phase 2 Clinical Trial of SGX942 for the Treatment of Oral Mucositis in Head and Neck Cancer Patients 6
... 8, 2011 Elsevier Business Intelligence , ... conferences, is hosting Windhover,s 21 st Pharmaceutical Strategic ... in New York, NY. PSA is the only ... a diverse mix of pharma,s top talent. It,s an opportunity ...
... Medical, a leading manufacturer of integrated medical imaging display and ... year, Carrot Medical achieved significant growth in sales and an ... of 2011 with record second quarter sales, Carrot surpassed its ... company is now well positioned for the third straight year ...
Cached Medicine Technology:Biopharma Leaders Discuss Pharma's Future at Pharmaceutical Strategic Alliances in New York 2Biopharma Leaders Discuss Pharma's Future at Pharmaceutical Strategic Alliances in New York 3Carrot Medical Positioned for Third Straight Year of Triple Digit Growth 2
(Date:8/31/2015)... (PRWEB) , ... August 31, 2015 , ... ... management, recently opened registration for the company’s second Introduction to Hyperbaric Medicine Course. ... October 15-18, 2015 aboard the Queen Mary Hotel in Long Beach, CA. The ...
(Date:8/31/2015)... ... August 31, 2015 , ... ... a one-day event geared to patients and family members, medical professionals, and researchers, ... regional mesothelioma experts. The conference is a collaborative effort between the Mesothelioma ...
(Date:8/31/2015)... , ... August 31, 2015 , ... Patients who thought ... those who are interested in learning more about the procedure beyond the information found ... , Internationally recognized hair transplant surgeon Parsa Mohebi will be on hand to answer ...
(Date:8/31/2015)... ... August 31, 2015 , ... The Sundance Film Festival ... Tuesday, September 1. , “Alive Inside” shadows a social worker who advocates for the ... “It’s a documentary about bringing music to residents in health care centers who may ...
(Date:8/31/2015)... ... August 31, 2015 , ... Garden State Urology is ... result of a merger of five of the busiest urology practices in Morris ... more cost-effective and higher quality care than they did individually. Their mission ...
Breaking Medicine News(10 mins):Health News:Registration Opens for Wound Care Advantage’s Second UHMS Approved 40-Hour Introduction to Hyperbaric Medicine Course 2Health News:Registration Opens for Wound Care Advantage’s Second UHMS Approved 40-Hour Introduction to Hyperbaric Medicine Course 3Health News:Registration Opens for Wound Care Advantage’s Second UHMS Approved 40-Hour Introduction to Hyperbaric Medicine Course 4Health News:New York Experts on Mesothelioma Come Together at Memorial Sloan Kettering Cancer Center 2Health News:New York Experts on Mesothelioma Come Together at Memorial Sloan Kettering Cancer Center 3Health News:Watch a Live Hair Transplant at Parsa Mohebi Hair Restoration’s Open House 2Health News:Public Invited to Dementia Documentary Screening at North Carolina Retirement Community 2Health News:NJ Top Docs Presents, Garden State Urology! 2
... is a dramatic shift in attitudes toward circumcision in Swaziland, ... of the practice and one of the highest HIV prevalence ... it is making a sudden comeback in the country since ... practice could reduce the risk of contracting HIV. ...
... of the most frequent New Year resolutions is "I'll quit ... find it hard to keep their good // ... Now an initiative undertaken by the Manchester Evening News, a ... resolution. ,The paper has undertaken this ...
... high as researchers feel that if mutation of the bird flu ... death world wide as the virus could have the capacity to ... in China from spread to poultry of bird flu virus from ... to bird flu recently in the Sanming City. World Health Organization ...
... death sentence. It is the most lethal cancer there is. ... GBM annually in the U.S., half // will ... The treatments include highly invasive surgeries to remove the tumor ... to a very low quality of life. Hence, researchers are ...
... University of Michigan’s researchers has revealed that those children who live ... to put on weight. As many as 16% of those belonging ... are reported to be overweight, while in the UK the number ... early 1990s. ,The researchers, led by Julie Lumeng, ...
... have one more reason to raise a toast- a formula ... you // can pep-up your spirits and relish ... Coventry University, and author of the formula for Marks & ... popping open a champagne bottle. According to smith, P = ...
Cached Medicine News:Health News:Men queue up for Circumcision In Swaziland To Prevent HIV/AIDS 2Health News:Radiology advance points way to non-invasive brain cancer treatment 2Health News:Surroundings Have An Effect On Weight 2
LUMIGAN® is a powerful eye drop medication for lowering IOP. IOP is short for intraocular pressure or eye pressure. LUMIGAN® is the first in a new class of medication....
... New REFRESH LIQUIGEL® Lubricant Eye Drops ... with the convenience of a liquid ... protection. Its extra-strength CMC formula provides ... comfort. And with the PURITE® preservative, ...
Due to its thick formula, REFRESH CELLUVISC Lubricant Eye Drops is ideal for persistent dry eye conditions. REFRESH CELLUVISC provides lasting relief and protection for dry, scratchy eyes....
... solution is an anti-infective prescription ... may instruct you to use ... infection caused by bacteria. Bacterial ... the 2 types of eye ...
Medicine Products: