Navigation Links
Rigel's R788 Significantly Improves Rheumatoid Arthritis in Phase 2b Clinical Trial
Date:7/9/2009

SOUTH SAN FRANCISCO, Calif., July 9 /PRNewswire-FirstCall/ -- Rigel Pharmaceuticals, Inc. (Nasdaq: RIGL) today announced that R788 (fostamatinib disodium) produced significant clinical improvement in rheumatoid arthritis (RA) patients in the recently completed TASKi2 Phase 2b clinical trial of 457 patients treated for up to 6 months. The groups treated with 100 mg of R788 bid (twice a day) and 150 mg qd (once a day) reported higher ACR 20, ACR 50, ACR 70 and DAS28 response rates than the placebo group. The efficacy results for the two dosing groups were comparable, although the response rates for the 100 mg bid group was uniformly greater. Consistent with the previous Phase 2a clinical trial (TASKi1), the onset of effect of R788 occurred within one week after the initiation of therapy and was maintained. The most frequent adverse events were expected based on TASKi1 and appear to be manageable. The significant, early and sustained efficacy, combined with a good safety profile, supports Rigel's plans to conduct corporate partnership discussions with respect to R788 and initiate a Phase 3 clinical program with R788 in RA in the first half of 2010 with a corporate partner.

Rigel will host a conference call today at 8:00am EDT/5:00am PDT to discuss these results (see conference call details below).

"These are impressive results," said James M. Gower, chairman and chief executive officer of Rigel. "The data from this clinical trial and the soon to be completed TASKi3 clinical trial, a total of over 670 patients, will guide the design of the Phase 3 trials that we plan to launch with a corporate partner in the first half of next year, " he added.


    Efficacy Results

    Treatment    N of Pts   ACR 20     ACR 50    ACR 70    DAS28<2.6

    Placebo        153      53 (35%)   29 (19%)  16 (10%)  9 (
'/>"/>
SOURCE Rigel Pharmaceuticals, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Study Suggests High-Dose Fish Oil May Significantly Improve Behavior in Children with ADHD
2. DEFLUX(R) Significantly Reduces Urinary Tract Infections in Children With Vesicoureteral Reflux
3. Vidaza Significantly Extends Overall Survival by 74% in Phase 3 Trial in Myelodysplastic Syndromes (MDS)
4. Nexavar Significantly Improved Overall Survival in Phase 3 Asia-Pacific Liver Cancer Trial
5. Study Shows Vasopressin Receptor Antagonist VAPRISOL(R) (Conivaptan Hydrochloride Injection) Significantly Increased Serum Sodium Concentration in Patients with Euvolemic & Hypervolemic Hyponatremia
6. New Data Reveal Topical Divigel(R) (estradiol gel) 0.1% Significantly Reduces Frequency and Severity of Hot Flashes
7. Promising Phase 3 Trial Results Show Novel Biologic Therapy Ustekinumab (CNTO 1275) Significantly Improved Psoriasis
8. INVEGA(TM) Significantly Reduced Symptoms of Schizophrenia Compared to SEROQUEL(R) in Acutely Ill, Hospitalized Patients
9. New Data Published in Neurology Show Once-Daily Lamictal XR Significantly Reduced Partial Seizures in Patients with Epilepsy
10. Anesiva Announces Pivotal Phase 3 Trial of Zingo(TM) Meets Primary Endpoint and Significantly Reduces Venous Access Pain in Adults
11. A Sociolinguistic Analysis of In-Office Dialogue Reveals Psychiatrists and Parents Have Significantly Different Perceptions on ADHD and Psychiatric Comorbidities
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... Laboratories, Inc. (Nasdaq: CBRX ) ("Columbia" ... the three and six-month periods ended June 30, ... from the contribution of the Molecular Profiles services ... an anticipated and temporary decline in product revenues ... in one high-volume, high-margin market. Throughout the renewal ...
(Date:7/31/2014)... 31, 2014 Auxilium Pharmaceuticals, Inc. ... biopharmaceutical company, today announced that the Company will ... its partner Asahi Kasei Pharma Corporation (Asahi Kasei). ... submission of a regulatory application to the Japanese ... ® (collagenase clostridium histolyticum) for the treatment ...
(Date:7/30/2014)...  There is still time to share your ... Annual Institute for Supply Management ® – ... Management is open for submissions.  The annual competition ... of supply management by recognizing supply management organizations ... practices.  Entries are due August 22, 2014. ...
Breaking Medicine Technology:Columbia Laboratories Reports Second Quarter 2014 Financial Results 2Columbia Laboratories Reports Second Quarter 2014 Financial Results 3Columbia Laboratories Reports Second Quarter 2014 Financial Results 4Columbia Laboratories Reports Second Quarter 2014 Financial Results 5Columbia Laboratories Reports Second Quarter 2014 Financial Results 6Columbia Laboratories Reports Second Quarter 2014 Financial Results 7Columbia Laboratories Reports Second Quarter 2014 Financial Results 8Columbia Laboratories Reports Second Quarter 2014 Financial Results 9Columbia Laboratories Reports Second Quarter 2014 Financial Results 10Columbia Laboratories Reports Second Quarter 2014 Financial Results 11Columbia Laboratories Reports Second Quarter 2014 Financial Results 12Auxilium Pharmaceuticals, Inc. Announces XIAFLEX Milestone: Partner Asahi Kasei Pharma Corporation Completes Regulatory Submission For Dupuytren's Contracture In Japan 2Auxilium Pharmaceuticals, Inc. Announces XIAFLEX Milestone: Partner Asahi Kasei Pharma Corporation Completes Regulatory Submission For Dupuytren's Contracture In Japan 3Auxilium Pharmaceuticals, Inc. Announces XIAFLEX Milestone: Partner Asahi Kasei Pharma Corporation Completes Regulatory Submission For Dupuytren's Contracture In Japan 4Auxilium Pharmaceuticals, Inc. Announces XIAFLEX Milestone: Partner Asahi Kasei Pharma Corporation Completes Regulatory Submission For Dupuytren's Contracture In Japan 5Institute for Supply Management, Michigan State University to recognize companies with excellent supply management practices 2
... EAST BRUNSWICK, N.J., Oct. 25 Savient Pharmaceuticals, Inc. (Nasdaq: ... host a conference call on Tuesday, October 26, 2010 at ... detail around its KRYSTEXXA™ launch plans. ... will host a live conference call on October 26, 2010 ...
... The National Community Pharmacists Association (NCPA) today announced ... by Cardinal Health , which found that independent community ... in 2009 despite a stagnant economy, the growing influence ... and the questionable business practices of pharmacy benefit managers ...
Cached Medicine Technology:Savient Pharmaceuticals to Hold Conference Call on October 26, 2010 at 8:30 a.m. Eastern Time 2Savient Pharmaceuticals to Hold Conference Call on October 26, 2010 at 8:30 a.m. Eastern Time 3NCPA Digest Finds Independent Community Pharmacies Stable Despite Economic, Third-Party Challenges 2NCPA Digest Finds Independent Community Pharmacies Stable Despite Economic, Third-Party Challenges 3NCPA Digest Finds Independent Community Pharmacies Stable Despite Economic, Third-Party Challenges 4
(Date:7/31/2014)... CA (PRWEB) July 31, 2014 Recognizing ... International Plant-based Nutrition Healthcare Conference announced today ... enrolled in studies of medicine or a healthcare-related field, ... advantage of special student-only discounts for the conference, scheduled ... the Loews Coronado Bay Resort. , “As ...
(Date:7/31/2014)... Many lawyers take up the law for ... injustices, and preserve the rule of law. Upholding these values ... as crusading and exemplary by some, but reckless and inconvenient ... seed might be planted within the legal system itself, the ... for an attorney - a referral to the bar's disciplinary ...
(Date:7/31/2014)... Angeles, CA (PRWEB) July 31, 2014 Staying ... can be tricky at best. Men and women get sucked ... husbands, wives, life partners, and taxi services to kids. ... Black, offers her "3 Fast + Fun Ways to Reignite ... free download . , “This is a much better ...
(Date:7/31/2014)... but no matter how hard you hit, your opponent ... said of highly treatment-resistant cancers, such as head and ... cells repair themselves, survive and thrive. Head and neck ... world, but the late detection and treatment resistance result ... of Michigan researchers have found that a particular proteinTRIP13encourages ...
(Date:7/31/2014)... Updox, the industry leader for ... release of a “Twelve Questions to Ask When Selecting a ... evaluating Health Information Service Providers (HISPs) for Direct Messaging to ... and Epic electronic health records (EHRs) need to separately contract ... using the Direct protocol. , “Selecting a HISP ...
Breaking Medicine News(10 mins):Health News:Student Discounts Offered for International Plant-based Nutrition Healthcare Conference 2Health News:Student Discounts Offered for International Plant-based Nutrition Healthcare Conference 3Health News:Supreme Court Press Petition of the Month for July 2014: Shutting Down Inconvenient Lawyers By Disbarment or Suspension 2Health News:Supreme Court Press Petition of the Month for July 2014: Shutting Down Inconvenient Lawyers By Disbarment or Suspension 3Health News:Couples in Trouble Relationship Expert, Dr. Jackie Black, Offers a Gift Guide to Reignite the Spark So Lovers Can Kiss-And-Make-Up 2Health News:Couples in Trouble Relationship Expert, Dr. Jackie Black, Offers a Gift Guide to Reignite the Spark So Lovers Can Kiss-And-Make-Up 3Health News:Updox Introduces Resources to Help Hospitals Choose the Right HISP for Direct Messaging 2Health News:Updox Introduces Resources to Help Hospitals Choose the Right HISP for Direct Messaging 3Health News:Updox Introduces Resources to Help Hospitals Choose the Right HISP for Direct Messaging 4
... , WASHINGTON, July 31 Speaker Nancy Pelosi issued ... and Commerce Committee to pass the America,s Affordable Health Choices Act, ... The House Ways and Means Committee and Education and Labor Committee ... "For more than 60 years, we have tried as a ...
... , , PHOENIX, July 31 ... of Columbus are gathering for their 127th annual convention, to be held ... in Phoenix, Arizona. The Knights of Columbus, founded in 1882, is ... 11 countries on three continents. , , In addition ...
... , , WASHINGTON, July 31 ... will be held in Copan Ruinas, Honduras on September 24-26, ... of over 110 medical brigades, universities, churches, hospitals, civic clubs ... companies involved in volunteer work in Honduras. , , ...
... cancer neuroblastoma are eight times more likely to have ... more likely to have lower incomes than their siblings, ... the Journal of the National Cancer Institute . ... on the long-term outcomes for neuroblastoma survivors. Caroline ...
... WASHINGTON, July 31 After adding abortion coverage and funding ... 3200, the Energy and Commerce Committee today rejected an amendment ... provide abortion coverage. Family Research Council President Tony Perkins ... , , (Logo: http://www.newscom.com/cgi-bin/prnh/20080930/FRCLOGO ) , ...
... , , , , ... Corp. (OTC Bulletin Board: BBVUF, BBVVF and BBVWF) (the "Company") announced ... Migami, Inc. to enter into a business combination. Pursuant to ... has until February 13, 2010 to complete the business combination. If ...
Cached Medicine News:Health News:Knights of Columbus Gather in Phoenix for 127th International Convention 2Health News:Conference on Honduras 2009 Set for Copan Ruinas 2Health News:Long-term health and social outcomes for neuroblastoma survivors 2Health News:Once Again, House Rejects Amendment Preventing Taxpayer Funding for Abortion 2Health News:BBV Vietnam S.E.A. Acquisition Corp. Announces Signing of Letter of Intent for Business Combination with Migami, Inc. 2
... CEQ 8000 is a fully automated genetic ... capillary array with a patented linear polyacrylamide ... applies the voltage program, and analyzes the ... data quality and even customize automated data ...
Basic critical care testing. Measures pH, pCO2, and pO2 from 85 L whole-blood sample....
... parameters from just 95 L of ... as well as any combination of ... Unique technology reduces to a minimum ... on the accuracy of blood gas, ...
348 is fully automated blood gas systems offering a cost-effective solution for critical care testing in settings with low to medium workloads....
Medicine Products: