Navigation Links
Rigel's R788 Demonstrates Significant Improvement in Rheumatoid Arthritis in Phase 2 Clinical Study
Date:12/13/2007

Achieves Statistically Significant ACR20, ACR50 & ACR70 Results

SOUTH SAN FRANCICSO, Calif., Dec. 13 /PRNewswire-FirstCall/ -- Rigel Pharmaceuticals, Inc. (Nasdaq: RIGL) today announced that its oral syk kinase inhibitor, R788 (tamatinib fosdium), has demonstrated statistically significant results in treating Rheumatoid Arthritis (RA) patients in a recently completed Phase 2 clinical trial. Groups treated with R788 at 100mg and 150mg po bid (orally, twice daily), showed higher ACR20, ACR50, ACR70 and DAS28 response rates than the placebo group. The efficacy results for the 100mg and the 150mg dose groups were fairly comparable. Dramatically, the onset of the effect in these dose groups occurred as early as one week after initiation of therapy. We believe that the significant ACR scores and good tolerability observed in this clinical trial, and the further benefit of oral delivery may make R788 a favorable alternative to the currently marketed biological agents.

Rigel will host a conference call today at 12:30 p.m. EST to discuss these results (see conference call details below).

"This clinical study has shown that R788 treatment can achieve impressive ACR response rates," said Elliott Grossbard, M.D., senior vice president of medical development at Rigel. "In this clinical trial both the 100mg and 150mg doses improved arthritis symptoms and did so quickly. We plan to initiate the next clinical trial with R788 in RA in 2008," he added.

Efficacy Results*

Treatment Assigned Number ACR 20 ACR 50 ACR 70 DAS28-CRP <2.6,

po bid (N) % (N) % (N) % (N) % (N)

Placebo 47 38% (18) 19% (9) 4% (2) 17% (8)

50 mg
'/>"/>

SOURCE Rigel Pharmaceuticals, Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Cytokine Demonstrates Oral Efficacy of Small-Molecule MIF Inhibitors
2. Lpath Demonstrates Strong Safety Profile of Lead Drug Candidate, Sphingomab(TM), in Non-Human Primates
3. ImmuneRegen BioSciences, Inc. Demonstrates Radilex(TM) Increases Disease-Fighting White Blood Cells
4. New Study Presented at WorldSleep 2007 Demonstrates Ramelteon Has Sustained Efficacy Over Six Months in Adults With Chronic Insomnia
5. Cypher(R) Sirolimus-Eluting Coronary Stent Demonstrates Sustained Clinical Benefits Compared to Bare Metal Stents in Five-Year Randomized Clinical Trial With No Differences in Long-Term Safety
6. Lpath Demonstrates Preclinical Efficacy of Lpathomab(TM) and Initiates Humanization Process
7. R7128 Demonstrates Safety and Potent Antiviral Activity in HCV-Infected Patients
8. Rochester Medical Anti-Infection Foley Catheter Demonstrates Effectiveness in Randomized Trial
9. New Study Demonstrates 4 Year Olds Fed Enfamil LIPIL(R) as Infants Have Brain and Eye Outcomes Similar to Breastfed Babies
10. ACTOS(R) (pioglitazone HCl) Demonstrates Reduced Risk of Ischemic Cardiovascular Disease in Patients with Type 2 Diabetes
11. Oritavancin Demonstrates Superior In Vitro Activity to Vancomycin and Metronidazole Against C. Difficile Bacteria
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... 2014 In September 2014, the staff at ... a new product development plan that started with the ... lab coat , aptly named "Vera G.," after ... the world. The new women,s designer lab coat is ... sleek envelope collar, vertical princess and high waist seaming, ...
(Date:11/21/2014)... N.J. , Nov. 21, 2014  PTC Therapeutics, Inc. ... the 2014 Legend of Technology Award for Vision, Innovation, and ... Ph.D., Chief Executive Officer. This award recognizes an individual who ... New Jersey for several decades. ... Technology Award," stated Stuart Peltz , Ph.D., CEO of ...
(Date:11/21/2014)... , Nov. 20, 2014  Market research firm Kalorama information ... of The Buy, in the medical device industry.  The ... devices will produce just 3% growth this year, which ... acquisitions of product lines and entrance by acquisition into ... of medical devices, The Global Market for Medical ...
Breaking Medicine Technology:Medelita Introduces Medical Industry's First Limited Edition Women's Designer Lab Coat 2PTC Therapeutics Announces CEO, Dr. Stuart Peltz Recipient of The New Jersey Technology Council's 2014 Legend of Technology Award 2PTC Therapeutics Announces CEO, Dr. Stuart Peltz Recipient of The New Jersey Technology Council's 2014 Legend of Technology Award 3Kalorama: 2014 The "Year of The Buy" in Medical Device Industry 2
... Aug. 17 In response to unprecedented devastation and human ... Foundations today announced it would give an additional $5 million ... "We need everyone to pitch in to the ... Open Society Foundation in Pakistan – FOSI-Pakistan. "While the government ...
... FEICHENG, China, Aug. 17 /PRNewswire-Asia-FirstCall/ -- ... ... var shortURL ... by longUrl, so we need to grab the first one. for (var r in data.results) { ...
Cached Medicine Technology:George Soros to Boost Civil Society Response in Flood Affected Areas of Pakistan 2China Ruitai International Holdings Co., Ltd. Reports Financial Results for the Second Quarter 2010 2China Ruitai International Holdings Co., Ltd. Reports Financial Results for the Second Quarter 2010 3China Ruitai International Holdings Co., Ltd. Reports Financial Results for the Second Quarter 2010 4China Ruitai International Holdings Co., Ltd. Reports Financial Results for the Second Quarter 2010 5China Ruitai International Holdings Co., Ltd. Reports Financial Results for the Second Quarter 2010 6China Ruitai International Holdings Co., Ltd. Reports Financial Results for the Second Quarter 2010 7China Ruitai International Holdings Co., Ltd. Reports Financial Results for the Second Quarter 2010 8China Ruitai International Holdings Co., Ltd. Reports Financial Results for the Second Quarter 2010 9China Ruitai International Holdings Co., Ltd. Reports Financial Results for the Second Quarter 2010 10China Ruitai International Holdings Co., Ltd. Reports Financial Results for the Second Quarter 2010 11China Ruitai International Holdings Co., Ltd. Reports Financial Results for the Second Quarter 2010 12China Ruitai International Holdings Co., Ltd. Reports Financial Results for the Second Quarter 2010 13China Ruitai International Holdings Co., Ltd. Reports Financial Results for the Second Quarter 2010 14China Ruitai International Holdings Co., Ltd. Reports Financial Results for the Second Quarter 2010 15
(Date:11/22/2014)... 23, 2014 A classic black prom dress ... most famous dress suppliers, has unveiled its new items of ... are now offered at a big discount, up to 70% ... , The new black prom dresses, made with the ... meet the needs of all customers, the company provides these ...
(Date:11/22/2014)... Today, Dylan Queen, a renowned brand in ... dresses; the business offers a wide range of special ... worldwide, allowing them to create multiple looks easily. , ... new collection of chic wedding dresses has been prepared ... at discounted rates now. Dylan Queen can always create ...
(Date:11/22/2014)... Discount-Dress.com is an important company in the ... increase the company’s online market share by a series of ... dresses and announced a bridesmaid dress promotion for the new ... 2014. All the dresses from this company are not only ... Discount-Dress.com is very good at manufacturing wedding dresses. Customers prefer ...
(Date:11/22/2014)... PITTSBURGH, PA (PRWEB) November 22, 2014 ... about the pain caused by the machine," said an ... injury, she had to go back a second time ... my invention idea." , She developed the patent-pending MAMO ... for breast cancer. The design saves the patient from ...
(Date:11/22/2014)... 22, 2014 (HealthDay News) -- The wide variety and ... a threat for people with food allergies, an expert ... so many types of food allergies that it can ... holidays," Dr. Guha Krishnaswamy, director of allergy and clinical ... a hospital news release. "If you know you ...
Breaking Medicine News(10 mins):Health News:New Black Prom Dresses from BellasDress.com 2Health News:Dylan Queen Introduces Its New Wedding Dresses 2Health News:Bridesmaid Dresses Introduced by Famous Company Discount-Dress.com For The New Year 2015 2Health News:'Tis the Season of Challenges for Those With Food Allergies 2
... Organization (WHO) it was found that tobacco usage is on ... It said that the industry is luring people and the ... The theme of the World No Tobacco Day states that ... addictive, harmful and can cause death. , Dr ...
... thing in the US of A is the best ... an independent environmental organisation Sierra Club to the tune ... water. They attribute it to the Environmental Protection Agency's ... and seasonal streams. ,Utah (79/2.0/90*), Colorado (68/3.6/83), ...
... diva Elizabeth Taylor took to the airways to try to quash ... ,"Do I look like I'm dying? Do I look like or ... broadcast of CNN's Larry King Live. ,The adamant 74-year-old, ... because of chronic back pain as she answered a range of ...
... in US is all set to use Singapore as a ... from leukaemia// , of the developing Southeast Asian countries. ... to be used in the transplants the children need. ... here," The Straits Times quoted Allen Yeoh, senior consultant at ...
... smoking-related lung damages in healthy smokers//. ,A harmless gas, helium is now ... the University of Wisconsin-Madison finds. MRI (magnetic resonance imaging),a diagnostic technique creates clear and ... images. ... ...
... survey on NHS hospitals revealed falling standards of cleanliness ... ,Comparing to 56 percent people in 2002, only 52 ... in 2003 said lavatories were very clean, but only ... NHS patients' survey reported high levels of general satisfaction ...
Cached Medicine News:Health News:Drinking water in America not all that safe: says report 2Health News:Helium And MRI Scanning Clearly Detects Smoker Lungs – Research Find 2
... BloodTrack Courier* controls and monitors the ... of hospital refrigerators. BloodTrack Courier provides a ... your hospital network. , BloodTrack Courier electronically ... hospital environment, from its receipt of blood ...
Lasts up to 3 months , Absorbable copolymer of glycolic acid and trimethylene carbonate , Designed to provide relief from short term dry eye conditions. , Appropriate for surgery-related d...
... Proclear Multifocal are the only contact ... experienced by those with aging eyes: presbyopia ... lenses combine a superior lens design, Balanced ... made using our patented PC Technology. The ...
... Accommodating Intraocular Lens is for the treatment of ... many middle aged and older patients. , Presbyopia ... the natural lens of the eye as a ... elastic. With less elasticity, the eye has a ...
Medicine Products: