Navigation Links
Rigel's R348 to Initiate Phase 2 Clinical Trial in Dry Eye
Date:5/22/2013

causing the symptoms of this condition.  A recently completed Phase 1 study of R348 in patients with dry eye disease showed that the drug candidate is well tolerated and Rigel expects to begin a Phase 2 study, titled DROPS (Dry eye Rigel Ophthalmic Phase 2 Study), shortly.  This multi-center, randomized, double-masked study, will evaluate two doses of R348 versus placebo administered twice a day over a three-month period in approximately 210 patients with dry eye disease.  The efficacy endpoints will include change from baseline in corneal staining, tear production and dry eye symptom scores.  Results of this Phase 2 study are expected in the first half of 2014.

R428/BGB324 AXL Kinase Inhibitor- BerGenBio
In June 2011, Rigel and Norway's BerGenBio entered into an agreement for Rigel's preclinical candidate, R428, which is an orally bioavailable and selective AXL kinase inhibitor.   Now called BGB324, this AXL kinase inhibitor is expected to be useful in the treatment of hematological and certain solid tumor cancers, including leukemia, pancreatic, and breast cancers.  AXL kinase expression by cancer cells is essential to metastatic dissemination and is linked with increasing resistance to current cancer therapeutics.  By inhibiting AXL kinase expression, BGB324 has been shown, in preclinical studies, to be effective as a single agent therapeutic in preventing and reversing acquired resistance to standard of care cytotoxics and targeted therapies, and may also slow or prevent tumor metastasis.   BerGenBio has filed an IMPD (IND-equivalent) and intends to conduct the first-in-human studies of BGB324 in Europe.

Ubiquitin Ligase Inhibitor – Daiichi Sankyo
Rigel and Daiichi Sankyo have a collaboration aimed at identifying small molecule drug candidates against a ligase target that controls cancer cell proliferation through pro
'/>"/>

SOURCE Rigel Pharmaceuticals, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Asubio Initiates Landmark Clinical Study in Spinal Cord Injury
2. CSL Behring Initiates Study of Subcutaneous Administration of C1-esterase Inhibitor in Patients with Hereditary Angioedema
3. Isis Initiates Phase 2 Study of ISIS-APOCIIIRx in Patients with Hypertriglyceridemia
4. Alder BioPharmaceuticals Inc. Initiates Phase 1 Clinical Study of Antibody Therapeutic Candidate for Treatment of Migraine, ALD403
5. ResMed Inc. Announces Plan To Initiate Dividend And Update On Chief Executive Officer Succession
6. Oncos Therapeutics Initiates Phase I Clinical Study of CGTG-102, an Oncolytic Adenovirus for the Treatment of Solid Tumor Cancers
7. MAQUET Initiates Class I Recall of the FLOW-i Anesthesia System
8. Stryker Initiates Voluntary Product Recall of Modular-Neck Stems
9. Inovio Initiates H1N1 Universal Influenza Vaccine Clinical Trial Targeting Over-65 Population, Which Represents 90% of Flu Deaths
10. ESTEVE Announces Publication of Key Preclinical Data for a Novel Oral, First-in-class New Chemical Entity (NCE) Sigma-1 Receptor Antagonist (E-52862), that has Completed Phase I and Initiated its Phase II Clinical Trial Program
11. Grifols Initiates Safety Study of Inhaled Alpha1-Proteinase Inhibitor (Human) Following Orphan Drug Designation for Cystic Fibrosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... Aug. 28, 2014 /PRNewswire-iReach/ -- Academy Leadership, an elite ... graduates, has published a case study highlighting ... Excellence Course . In September and October 2014, Academy ... to Albuquerque , Indianapolis , Salt ... Photo - http://photos.prnewswire.com/prnh/20140828/140814 Leadership ...
(Date:8/28/2014)... MINNEAPOLIS , Aug. 28, 2014 Nonin ... a leader in noninvasive medical monitoring, today announced that ... Nonin Model 3231 OEM/eHealth finger pulse oximeter for use ... finger pulse oximeter plugs into a telemedicine hub or ... and pulse rate in pediatric to adult patients. The ...
(Date:8/28/2014)... , August 28, 2014 ... Market Research "Radiofrequency Identification (RFID) Market (Tags, Readers, Middleware, ... Growth, Trends and Forecast, 2014 - 2020" the global ... billion in 2013 and is expected to grow at ... reach an estimated value of USD 5.3 billion in ...
Breaking Medicine Technology:Academy Leaders Publishes Case Study on Work with Global Pharmaceutical Company 2Academy Leaders Publishes Case Study on Work with Global Pharmaceutical Company 3Academy Leaders Publishes Case Study on Work with Global Pharmaceutical Company 4Academy Leaders Publishes Case Study on Work with Global Pharmaceutical Company 5Nonin Medical Announces FDA Clearance of Nonin Model 3231 USB Pulse Oximeter 2Radiofrequency Identification (RFID) Market in Healthcare is Expected to Reach USD 5.3 Billion Globally by 2020: Transparency Market Research 2Radiofrequency Identification (RFID) Market in Healthcare is Expected to Reach USD 5.3 Billion Globally by 2020: Transparency Market Research 3Radiofrequency Identification (RFID) Market in Healthcare is Expected to Reach USD 5.3 Billion Globally by 2020: Transparency Market Research 4Radiofrequency Identification (RFID) Market in Healthcare is Expected to Reach USD 5.3 Billion Globally by 2020: Transparency Market Research 5
... , SOLON, Ohio, Dec. 16 HDT ... next generation technologies and a principal subcontractor for the ... development of new anthropromorphic arm technology that will give ... hand, including a sense of touch. , As ...
... , SOMERVILLE, N.J., Dec. 16 ... JNJ ) company and a worldwide leader in surgical care, ... to designing, developing and commercializing devices that address conditions affecting ... merger agreement whereby Ethicon will acquire Acclarent in an all-cash ...
Cached Medicine Technology:HDT Develops Robotic Arm Technology for DARPA's Revolutionizing Prosthetics 2009 Program 2Ethicon Announces Definitive Agreement to Acquire Acclarent 2Ethicon Announces Definitive Agreement to Acquire Acclarent 3Ethicon Announces Definitive Agreement to Acquire Acclarent 4
(Date:8/28/2014)... 29, 2014 Doctors Frank DellaCroce and ... Breast Surgery (CRBS) and the St. Charles ... to announce that board certified surgeon Dr. Craig Ashley ... surgeons devoted to reconstructive breast surgery. Blum will work ... Sullivan, Christopher Trahan, and M. Whitten Wise. , “We ...
(Date:8/28/2014)... August 29, 2014 Involution ... some of the healthcare industry's most pressing problems, ... radically rethink health. Involution Studios' creative team ... creating software solutions for clients including AstraZeneca, 3M ... As part of the studio's philosophy to change ...
(Date:8/28/2014)... Alexandria, VA (PRWEB) August 28, 2014 ... Foundation (Meso Foundation) is able to accept donations in ... give. The Bitcoin donation page can be found at ... businesses are accepting Bitcoin as a form of payment, ... the same,” said Meso Foundation’s chief executive officer, Melinda ...
(Date:8/28/2014)... Recently, Skmen.com, one of the most popular suppliers ... collection of long sleeve sweater dresses and ... company’s newly unveiled sweater outfits are available at discounted ... a matter of fact, Skmen.com’s fashionable and quality items ... years. The company’s experienced tailors are striving to make ...
(Date:8/28/2014)... Dallas, TX (PRWEB) August 29, 2014 ... and in-depth study on the current state of the ... provides a basic overview of the industry, including definitions, ... Chinese domestic market analysis are provided with a focus ... market. A comparison between the international and Chinese situation ...
Breaking Medicine News(10 mins):Health News:New Plastic Surgeon Joins Center For Restorative Breast Surgery 2Health News:Top Three Open Source Design Concepts that Rethink Health from Involution Studios 2Health News:Top Three Open Source Design Concepts that Rethink Health from Involution Studios 3Health News:Cancer Research Funding Organization Now Accepts Bitcoin Donations 2Health News:Skmen.com: Bestselling Long Sleeve Sweater Dresses Are Offered Online Now 2Health News:Global Oscilloscope Industry (North America, Europe, Asia, and ROW) Forecast Report 2020 Now Available at ReportsnReports.com 2Health News:Global Oscilloscope Industry (North America, Europe, Asia, and ROW) Forecast Report 2020 Now Available at ReportsnReports.com 3
... ... ... ... WHEATON, Ill. , March 17 Life Care Services LLC (LCS) of Des Moines, Iowa , recently announced the acquisition of Wyndemere Senior Living Community in ...
... million Americans don,t know they have type 2, experts say ... of Americans have prediabetes and are at high risk for ... "Look around you. We are surrounded by [diabetes] risk," Christine ... American Diabetes Association, said in a news release. She said ...
... powers of standard risk model , WEDNESDAY, March 17 (HealthDay ... risk-assessment model for breast cancer won,t do much to help ... study shows. , Assessing a woman,s breast cancer risk remains ... relied on what,s known as the "Gail model," which asks ...
... March 17 Recent laboratory experiments which seek to recreate the formation of the first living ... occurred on earth and on other planets, biologist Jack Szostak and chemist Brian Paegel ... the Scripps Research Institute. , ... ...
... March 17 Massage Prep, the massage industry,s ... study program for the NCETM , NCETMB ... muscle tutorials, 25 interactive study guides, and 7 skeletal tutorials, ... narration for auditory learners, further cement the Massage Prep guarantee ...
... CITYTreating virulent influenza, sepsis, and other potentially deadly infections long ... bacteria. But new research from the University of Utah and ... inflammatory response to infection may help save more lives. ... Translational Medicine , researchers led by U of U cardiologist ...
Cached Medicine News:Health News:Wyndemere Senior Living Community Acquired by Life Care Services 2Health News:Wyndemere Senior Living Community Acquired by Life Care Services 3Health News:Wyndemere Senior Living Community Acquired by Life Care Services 4Health News:Online, Phone Tests Assess Diabetes Risk 2Health News:Newer Genetic Info Adds Little to Predicting Breast Cancer 2Health News:Newer Genetic Info Adds Little to Predicting Breast Cancer 3Health News:Top Scientists Explore the Origin of Life in Annual Lasker Lecture at Scripps Research Institute Florida Campus 2Health News:Top Scientists Explore the Origin of Life in Annual Lasker Lecture at Scripps Research Institute Florida Campus 3Health News:Top Scientists Explore the Origin of Life in Annual Lasker Lecture at Scripps Research Institute Florida Campus 4Health News:Top Scientists Explore the Origin of Life in Annual Lasker Lecture at Scripps Research Institute Florida Campus 5Health News:Massage Prep(TM) Announces New Interactive Tutorials for NCETM, NCETMB and MBLEx 2Health News:Massage Prep(TM) Announces New Interactive Tutorials for NCETM, NCETMB and MBLEx 3Health News:Massage Prep(TM) Announces New Interactive Tutorials for NCETM, NCETMB and MBLEx 4Health News:Massage Prep(TM) Announces New Interactive Tutorials for NCETM, NCETMB and MBLEx 5Health News:Massage Prep(TM) Announces New Interactive Tutorials for NCETM, NCETMB and MBLEx 6Health News:Targeting blood vessels, immune system may offer way to stop infection-caused inflammation 2Health News:Targeting blood vessels, immune system may offer way to stop infection-caused inflammation 3
The DePuy ACE Titanium Active Compression Plate offers ingenuity in the art of fracture management....
Long Handled Trephine...
... control you've come to demand in BD ... BD K-4000 microkeratome is built upon. , ... monitoring. The front panel on the new ... and bright visual feedback., ,The BD K-4000 ...
... third-generation allergy test , 3gAllergy is a ... provides quantitative determination of allergen-specific IgE at ... and lot-to-lot reproducibility. The assay delivers reliable ... you identify, monitor and manage patients with ...
Medicine Products: