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Rigel To Focus On ITP, DLE And Dry Eye
Date:9/5/2013

s from a Phase 2 clinical study of R333 in DLE are expected in Q4 2013. 

Dry Eye

Dry eye disease is an inflammatory disease of the eye that affects more than 5 million Americans.  The disease targets the lacrimal (tear producing) glands of the eye and may be associated with other autoimmune conditions including Sjögren's syndrome, systemic lupus erythematosus and rheumatoid arthritis.  Rigel has developed a topical ophthalmic (eye drop) formulation of R348, a JAK and SYK inhibitor, aimed at reducing the inflammation responsible for the symptoms of this disease.  Results of a Phase 2 study of R348 in chronic dry eye are expected in Q2 2014.

About Rigel (www.rigel.com)

Rigel Pharmaceuticals, Inc. is a clinical-stage drug development company that discovers and develops novel, small-molecule drugs for the treatment of inflammatory and autoimmune diseases, as well as muscle disorders.  Rigel's pioneering research focuses on intracellular signaling pathways and related targets that are critical to disease mechanisms. The company currently has five product candidates in clinical development: fostamatinib, an oral SYK inhibitor for ITP; R333, a topical JAK/SYK inhibitor for discoid lupus, and R348, a topical JAK/SYK inhibitor for dry eye – both in Phase 2 clinical trials; and two oncology product candidates in Phase 1 development with partners BerGenBio and Daiichi Sankyo.

This press release contains "forward-looking" statements, including, without limitation, statements related to development plans, the focus and direction of Rigel's resources, the timing of planned clinical trials and results, Rigel's ability to fund and manage its clinical programs in-house, Rigel's plans with respect to a reduction in force and restructuring charges associated with those reductions in force, and Rigel's ability to fund and maintain its current development pla
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SOURCE Rigel Pharmaceuticals, Inc.
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