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Rigel Initiates Phase 2 Clinical Studies with R343 for Asthma and R333 for Discoid Lupus
Date:9/5/2012

s Foundation of America states that more than 16,000 new cases are diagnosed in the US each year. DLE patients may frequently suffer inflamed disk-shaped sores on the face, chest and scalp, which may cause scarring, swelling and hair loss.  The acute phase of this disorder (and its cousin, SLE) is connected to SYK signaling within the body's immune cascade.  The chronic phase of these disorders is characterized by an abundance of JAK signaling. 

R333 and Discoid Lupus
Currently available treatments for DLE have either poor efficacy or significant toxicities. Rigel's R333 is a potent, topical JAK and SYK inhibitor that is designed to interrupt pivotal inflammatory cascade signals with the potential to prevent or diminish both acute and chronic phases of this disorder. To view Rigel's animation on R333 in DLE, go to www.rigel.com/rigel/discoid_lupus.

About Rigel (www.rigel.com)
Rigel Pharmaceuticals, Inc. is a clinical-stage drug development company that discovers and develops novel, small-molecule drugs for the treatment of inflammatory and autoimmune diseases, as well as muscle disorders. Rigel's pioneering research focuses on intracellular signaling pathways and related targets that are critical to disease mechanisms. Rigel's productivity has resulted in strategic collaborations with large pharmaceutical partners to develop and market its product candidates. Current product development programs include fostamatinib, an oral SYK inhibitor that is in Phase 3 clinical trials for rheumatoid arthritis with its partner AstraZeneca; R343, an inhaled SYK inhibitor for asthma and R333, a topical JAK/SYK inhibitor for discoid lupus – both of which have commenced Phase 2 clinical trials; and R548, an oral JAK3 inhibitor for the treatment of transplant rejection and other immune disorders.

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