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Rigel Initiates Phase 2 Clinical Studies with R343 for Asthma and R333 for Discoid Lupus
Date:9/5/2012

ematosus (SLE) will be randomized into two groups. One group will receive R333 in a topical ointment and the other a placebo ointment to be administered on the lesions twice daily for four weeks. The primary endpoints of this study will be the measurement of each person's decrease in the total combined Erythema and Scaling Score of all treated lesions from baseline to Day 28.  Rigel expects to complete this study in 2013.

Allergic Asthma
The Asthma and Allergy Foundation of America estimates that 20 million people in the U.S. have asthma; the majority of them classified as allergic asthma.  Despite the currently available therapies, approximately 25%, or approximately 2 million, of all Emergency Room visits each year are attributed to acute and severe episodes of this disease. The research conducted thus far on the novel mechanism of action of R343 suggests that this single agent may provide therapeutic benefit to counter both acute/early and chronic/late inflammation mechanisms.

R343 and Asthma
In patients with allergic asthma, allergens, such as pollen, trigger the production of immunoglobulin E (IgE) antibodies, which then bind to mast cells (the body's defense system gatekeepers) and spark a cascade of intracellular signals to mount an immune response resulting in swelling and inflammation of the airways.  SYK is a cellular protein that plays a pivotal role in IgE receptor signaling in mast cells. Rigel's R343 is designed to bind to the SYK in mast cells to interrupt the signal from the IgE receptors. R343's ability to inhibit SYK potentially prevents or stops the immune response to the allergen and may be effective in the short and long-term control of allergic asthma. To view Rigel's R343 animation, go to www.rigel.com/rigel/aa.

Discoid Lupus
Approximately 300,000 Americans suffer from Discoid Lupus, an autoimmune disorder of the skin, and the Lupu
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SOURCE Rigel Pharmaceuticals, Inc.
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