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Rigel Announces Fourth Quarter and Year End 2011 Financial Results
Date:3/6/2012

studies with R348 by the end of 2012.  
  • R256, inhaled interleukin 13 (IL13) signaling inhibitor for chronic asthma.  This selective and potent IL13 inhibitor is in preclinical studies aimed at evaluating its ability to reduce airway inflammation generally associated with chronic asthma and potentially improve the health of the lungs.
  • Intravenous inhibition of GDF8 signaling for muscle strength.  One of Rigel's programs aimed at muscle health, this preclinical program is focused on inhibiting the GDF8 signaling cascade which leads to loss of muscle in a variety of chronic disease states, but particularly in regard to loss of diaphragm muscle mass and strength (atrophy) associated with respiratory ventilator use.  Preclinical studies have shown that inhibiting GDF8 signaling may be therapeutically useful to prevent muscle loss and improve muscle function.  
  • Oral AMP-activated Kinase (AMPK) activation for muscle endurance.  Patients with chronic illnesses such as chronic heart failure, COPD or diabetes, often experience a decrease in strength and increase in fatigue due to muscle myopathy.  Rigel is conducting preclinical studies of an oral activator of AMPK to improve the body's energy utilization and restore muscle endurance in chronically ill subjects.  

  • About Rigel (www.rigel.com)

    Rigel is a clinical-stage drug development company that discovers and develops novel, small-molecule drugs for the treatment of inflammatory and autoimmune diseases, as well as muscle disorders. Rigel's pioneering research focuses on intracellular signaling pathways and related targets that are critical to disease mechanisms. Rigel's productivity has resulted in strategic collaborations with large pharmaceutical partners to develop and market its product candidates. Current product development programs include fostamatinib, an oral SYK inhibitor that is in Phase 3 c
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    SOURCE Rigel Pharmaceuticals, Inc.
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