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Rigel Announces Fourth Quarter and Year End 2011 Financial Results
Date:3/6/2012

largest group of patients with allergic asthma whose symptoms range from acute to chronic phases of the disease.   Rigel expects to initiate a Phase 2 clinical study with R343 for the treatment of allergic asthma in the summer of 2012.
  • R548, an oral JAK3 inhibitor.  In the fourth quarter of 2011, Rigel initiated Phase 1 clinical studies of R548 with a focus on its potential to treat transplant rejection and other immune system disorders.  More than 50% of organ transplant patients suffer chronic organ rejection in the 5-10 years post transplant surgery.  Currently available therapeutics are not sufficient to achieve lasting recovery and limit the range of transplant options for certain organs.  R548 is expected to moderate the immune system's response to the allograft and improve patient outcomes.  
  • R333, a topical (ointment) JAK/SYK inhibitor for discoid lupus.   Rigel initiated a Phase 1 clinical study of its topical agent in the fourth quarter of 2011 to test its application in treating acute and chronic phases of Discoid Lupus Erythematosus (DLE).  This autoimmune disease of the skin is characterized by disc-shaped sores with inflammation, swelling, scaling, scarring, pigment discolorations and even hair loss. The lesions most commonly appear in sun exposed areas, predominantly on the face, chest and scalp. Current treatments for DLE have either poor efficacy or significant toxicities. Rigel expects to initiate a Phase 2 clinical study with R333 in the summer of 2012.
  • R348, topical (drops) JAK/SYK inhibitor for dry eye.   Rigel is developing a soluble JAK/SYK inhibitor for topical ophthalmic use to treat Sjogren's syndrome, an autoimmune disorder that affects the lacrimal glands of the eye (tear ducts).  Sjogren's affects nearly four million Americans, and present therapies for this chronic and painful condition are only minimally effective.  Rigel plans to initiate Phase 1 clinical
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