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Rib-X Pharmaceuticals Reports Positive Top-Line Results from Phase 2 Study of Delafloxacin
Date:12/8/2008

- Fluoroquinolone Compound Demonstrates Potent Activity Against Antibiotic Resistant Gram-Positive Pathogens and MRSA in Skin Infections -

NEW HAVEN, Conn., Dec. 8 /PRNewswire-FirstCall/ -- Rib-X Pharmaceuticals, Inc. ("Rib-X" or the "Company"), a development-stage company focused on the discovery, development and commercialization of novel antibiotics for the treatment of antibiotic-resistant infections, today announced positive topline results from a Phase 2 clinical trial with the intravenous form of its novel anionic quinolone antibiotic, delafloxacin (RX-3341). The double-blind study showed that both doses (300mg BID and 450mg BID) of delafloxacin were as efficacious as the FDA approved dosing regime for tigecycline in the treatment of complicated skin and skin structure infections (cSSSI). Additionally, when evaluated in vitro against the Gram-positive and Gram-negative organisms isolated from patients within this trial, delafloxacin was shown to be the more active compound overall, including its activity against Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) and quinolone-resistant Gram-positive pathogens.

"This is the third Phase 2 clinical trial showing delafloxacin to be both efficacious and safe," said Susan Froshauer, PhD, President and CEO of Rib-X Pharmaceuticals. "The data for delafloxacin continues to show that this broad spectrum compound is likely to be a valuable tool in the armamentarium of agents for treatment of resistant bacterial infections. In fact, delafloxacin has been shown to be extremely effective against resistant Gram-positive bacteria, including MRSA. While we look forward to a complete review of the final data and in particular the subset data, we are encouraged by these results and the two previous Phase 2 studies, and we will continue to focus on the development of this potent antibiotic."

The Company is developing both the oral and
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SOURCE Rib-X Pharmaceuticals, Inc.
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