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Rib-X Pharmaceuticals Reports Positive Phase 2 Study Results for Next Generation Oxazolidinone at 2008 ICAAC/IDSA Joint Meeting
Date:10/26/2008

d Haemophilus influenzae and a once-a-day option at a significantly lower dose than linezolid. Additionally, these results further validate Rib-X's proprietary discovery and development approach which led to the identification of this compound as well as multiple other novel compounds in various classes which are able to circumvent bacterial resistance mechanisms."

Study Results

The poster, entitled "A Phase 2 Study Comparing Two Doses of Radezolid to Linezolid in Adults with Uncomplicated Skin and Skin Structure Infections (uSSSI)," reported that clinical cure rates with a 95% confidence interval in clinically evaluable patients were 97.4% for patients treated with radezolid at a dosage of 450 mg once a day (38/39); 94.4% for patients treated with radezolid 450 mg twice a day (36/39); and 97.4% for patients treated with linezolid 600 mg twice a day (37/38).

Clinical cure rates among clinically evaluable patients with confirmed MRSA infections with a 95% confidence interval were 100% and 92.9% for patients treated with radezolid once a day (8/8) and twice a day (13/14), respectively, and 93.3% for patients treated with linezolid 600 mg twice a day (14/15). In microbiologically evaluable patients, eradication was achieved in 100% of the group treated with radezolid at 450 mg once a day (20/20), and 87.5% in the group receiving radezolid 450 mg twice daily (21/24), versus 91.3% in the group receiving linezolid 600 mg twice daily (21/23).

uSSSI Phase 2 Trial Design

This Phase 2 trial, which enrolled 150 patients, was a multicenter, randomized, open-label, comparative study conducted at 19 clinical centers across the U.S. to evaluate the safety and efficacy of radezolid versus linezolid in the outpatient treatment of adult patients with uncomplicated skin and skin structure infections (uSSSI). The study assessed the efficacy of a 450mg dose of radezolid given orally, either once daily or twice daily for five to ten days compared to a 6
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SOURCE Rib-X Pharmaceuticals, Inc.
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