Navigation Links
Rib-X Pharmaceuticals Reports Positive Phase 2 Study Results for Next Generation Oxazolidinone at 2008 ICAAC/IDSA Joint Meeting
Date:10/26/2008

- Once-a-Day Radezolid Clinically and Microbiologically As Effective As Twice-a-Day Linezolid When Used to Treat a Variety of uSSSIs -

NEW HAVEN, Conn., Oct. 26 /PRNewswire/ -- Rib-X Pharmaceuticals, Inc. ("Rib-X" or the "Company"), a development-stage company focused on the discovery, development and commercialization of novel antibiotics for the treatment of antibiotic-resistant infections, today announced positive results from a Phase 2 clinical trial with the oral form of its compound, radezolid (RX-1741), for the treatment of uncomplicated skin and skin structure infections (uSSSI). These results were announced at the 48th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC)/Infectious Diseases Society of America (IDSA) 46th annual meeting (2008 ICAAC/IDSA Joint Meeting) held October 25 - 28 in Washington, D.C.

The open-label trial met both its primary (efficacy) and secondary (safety) endpoints. All doses of radezolid were as efficacious as linezolid (Zyvox(R), currently marketed by Pfizer) and demonstrated a good safety profile. The study also showed that radezolid was approximately four times more potent than linezolid against bacteria cultured from subjects in the study, including against methicillin-resistant Staphylococcus aureus (MRSA), with MIC90s of 0.5mg/L and 2.0mg/L respectively. MIC90s for other relevant bacterial isolates in the study were 0.5mg/L and 2.0mg/L for MRSA and 0.25mg/L and 1.0ug/ml for Streptococcus pyogenes for radezolid and linezolid, respectively. MIC90 is defined as the minimum inhibitory concentration necessary to inhibit the growth of 90 percent of the bacteria.

"We are pleased to report that our novel oxazolidinone, radezolid, may provide a safe and more potent alternative to the only currently marketed drug in this antibiotic class," said Susan Froshauer, PhD, President and CEO of Rib-X Pharmaceuticals. "In particular, radezolid offers a broader spectrum that includes atypicals an
'/>"/>

SOURCE Rib-X Pharmaceuticals, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Rib-X Pharmaceuticals to Present at 10th Annual Superbugs & Superdrugs Conference
2. Rib-X Pharmaceuticals Renews Collaborative Agreement with the Medical Research Council
3. Rib-X Pharmaceuticals Initiates Phase 2 Trial for RX-3341 In Complicated Skin and Skin Structure Infections
4. Rib-X Pharmaceuticals, Inc. Announces Recent and Upcoming Presentations at Scientific Conferences
5. Auxilium Pharmaceuticals, Inc. Receives Clearance to Resume Clinical Trials for XIAFLEX(TM)
6. Vion Pharmaceuticals Completes Accrual of 85 Patients to its Pivotal Phase II Trial of Cloretazine(R) (VNP40101M) in Elderly AML
7. Solvay Pharmaceuticals, Inc. and Wyeth Pharmaceuticals Announce Receipt of an FDA Action Letter for Bifeprunox, an Investigational Treatment for Schizophrenia
8. Callisto Pharmaceuticals Opens Additional Sites for Phase II Clinical Trial of Atiprimod in Advanced Carcinoid Cancer Patients
9. WallSt.net (www.wallst.net) Updates the Investment Community Through an All-New Interview With RegeneRx Biopharmaceuticals CEO
10. Quark Pharmaceuticals, Inc. Presented Positive Preclinical Results of Systemic RNAi Compound for Acute Renal Failure (ARF)
11. Peregrine Pharmaceuticals Doses First Patient in Cotara(R) Phase II Brain Cancer Trial In India
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/4/2015)... P&S Market Research releases ... DRO analysis, market segmentation, market size and forecast, ... competitor profiles in: Global Industry Insight: ... Demand Forecast to 2020       (Logo: ... reports with detailed TOC on Global Drug of ...
(Date:8/4/2015)... Aug. 04, 2015 ... the addition of Jain PharmaBiotech,s new report ... to their offering. This report describes ... veterinary medicine and pharmaceuticals as well as improvement ... important in the application of biotechnology to manage ...
(Date:8/4/2015)... Among 1,000 U.S. consumers, the majority (65.3 ... consumers surveyed are aware of prescription savings cards, and ... according to findings from a new survey released today ... on improving the health and well-being of individuals, families ... men and women, ages 21 and older, on their ...
Breaking Medicine Technology:Global Drug of Abuse (DOA) Testing Market (Size of $2.9 Billion in 2014) to Witness 5% CAGR During 2015 - 2020 2Global Drug of Abuse (DOA) Testing Market (Size of $2.9 Billion in 2014) to Witness 5% CAGR During 2015 - 2020 3Global Drug of Abuse (DOA) Testing Market (Size of $2.9 Billion in 2014) to Witness 5% CAGR During 2015 - 2020 4Global Drug of Abuse (DOA) Testing Market (Size of $2.9 Billion in 2014) to Witness 5% CAGR During 2015 - 2020 5Animal Biotechnology 2014-2024 - 2015 Technologies, Markets and Companies Analysis 2Animal Biotechnology 2014-2024 - 2015 Technologies, Markets and Companies Analysis 3New Study Finds Consumers are Leaving Money at the Pharmacy 2New Study Finds Consumers are Leaving Money at the Pharmacy 3
... May 11 Despite significant international travel restrictions ... UBM International Media and sister company UBM Japan Co. Ltd. ... 2010 Japanese Pharma events cluster, which took place from 21-23 ... an increase of 3.8% over 2009 attendance levels, the success ...
... RF Technologies®, a leading provider of healthcare safety and security solutions, ... Safe Place® Infant Security Solutions. The soft, stretchy banding material and technologically ... a Safe Place bracelet is loose, tampered with or is cut. ... Smart Sense was developed ...
Cached Medicine Technology:UBM Japan Pharma Events Grow Despite Air Travel Disruptions 2UBM Japan Pharma Events Grow Despite Air Travel Disruptions 3UBM Japan Pharma Events Grow Despite Air Travel Disruptions 4Smart Sense(TM) From RF Technologies Upgrades Safe Place(R) Bracelets Using Industry-Leading Infant Security Technology, Fit and Comfort 2
(Date:8/4/2015)... ... August 05, 2015 , ... Renowned review site BestMillionaireDatingSites.com recently refreshed its list ... has been ranked as the best dating service in the segment. , A representative ... It is essential that people find the right dating platform so that they can ...
(Date:8/4/2015)... ... August 05, 2015 , ... The National Association ... inductee into its VIP Woman of the Year Circle. She is recognized with ... organization exclusively for professional women, boasting more than 700,000 members and over 200 ...
(Date:8/4/2015)... ... ... NOVA Pride , Northern Virginia’s largest and newest LGBTQ nonprofit organization, ... join them in paving “The Road Ahead” at the second annual Northern Virginia Pride ... 2015, from 12-9pm. In order to ensure the success of this important event, NOVA ...
(Date:8/4/2015)... ... 2015 , ... How cool is it to check in at your favorite ... "Now" feature will soon allow you to do just that. , Ahhaa is releasing ... the now feature. , Users will soon get to share what inspires them about ...
(Date:8/4/2015)... , ... August 04, 2015 , ... Statement by Paul ... the introduction of the Mental Health Reform Act of 2015 by Senators ... mental health reform a reality in America. , “This legislation and H.R. ...
Breaking Medicine News(10 mins):Health News:BestMillionaireDatingSites.com Publishes Reviews of the Best Dating Sites for Wealthy Singles 2Health News:NAPW Inducts Deborah Stevens, Executive Assistant to Chairman and CEO at Mirion Technologies, Inc., Into its VIP Woman of the Year Circle 2Health News:NOVA Pride Announces Theme for the 2015 Northern Virginia Pride Festival 2Health News:NOVA Pride Announces Theme for the 2015 Northern Virginia Pride Festival 3Health News:NOVA Pride Announces Theme for the 2015 Northern Virginia Pride Festival 4Health News:Ahhaa App Soon to Release the "Now" Feature 2Health News:MHA Applauds Introduction of Mental Health Reform Act of 2015 2Health News:MHA Applauds Introduction of Mental Health Reform Act of 2015 3
... a device to monitor diabetics' blood sugar levels and ... on finger-prick blood tests and injections. ,The ... computer to monitor the patient's blood sugar levels and ... a media report. ,The key is the ...
... playing in the park; ,Age is grey,a toothless hag ... four lines reflect the glory of youth and the dismal ... romanticize youth, they shrink from the thought of greying hair, ... infirmities of old age. ,With the changing ...
... of anabolic steroids is linked to criminal activity such ... study published on Monday. // ,The ... of the muscle-building drugs however also revealed that steroid ... violent crimes such as murder, assault, rape and property ...
... Canadians are getting heavier , but a new study by Statistics Canada ... the same pace as they did earlier. //Adults between 18-64 were ... The data showed that they have put on weight steadily , but ... decreased. ,This welcome news is thought to be due to the ...
... have no one to look out for them. They are ... in the community without any money or family of their ... condition that impairs their judgment or ability to communicate. ... baby boomers age. ,There is only one state-funded program ...
... many parts of the world, the moral and legal aspects ... Various methods of inducing //abortions have been used throughout history ... crossed five in North America, who died from toxic shock ... people questioning the safety of the combination of the drugs ...
Cached Medicine News:Health News:Botox – The 'Celebrity' Dru 2Health News:Steroid Use Linked to Crimes 2Health News:Hoosiers Live at the Mercy of Nursing Homes 2Health News:Hoosiers Live at the Mercy of Nursing Homes 3Health News:Medically Induced Abortions (MIAs) Causes More Deaths Due To Infection 2
Maxi XL Hybridization Oven for Extra Large bottles. 6 bottle (70 mm) rotisserie + shaker tray available for simultaneous use. Includes linear and orbital shaker trays, 4 extra large bottles, pack o...
... Dimensions (WxDxH): 31.1 x 13.6 x 15.3 ... 22.4 x 20.5 cm, Capacity: 4 - ... x 35 mm bottles, 4 - 150 ... 240 x 80 mm bottle, Power Requirements: ...
... : Temperature controlled oven containing a rotisserie ... incubation of Northern, Southern and Western blots. ... and staining. Use of bottle hybridizations allows ... enhanced sensitivity and reduced reagent costs. Acrylic/polycarbonate ...
... Minifold I system consists of four basic components: ... and metal clamping plate (see diagram). The sample ... producing spots, dots, or slots (see below). All ... as an accessory plate in conjunction with a ...
Medicine Products: