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Rib-X Pharmaceuticals, Inc. Co-Founder, Thomas A. Steitz, Ph.D., Awarded the 2009 Nobel Prize in Chemistry
Date:10/7/2009

Board, have worked closely with Dr. Steitz; together they received the Rosenstiel Award for Distinguished Work in Basic Medical Sciences for their research on the ribosome in 2001.

Rib-X was built on the extraordinary science of these founders and utilizes this award winning knowledge of the structure and function of the ribosome. Their hard work has yielded several distinctive new antibiotics that can be used for the treatment of multi-antibiotic resistant infections. These include three programs -- radezolid, Rx-04 and Rx-02 -- that are derived from Rib-X's proprietary discovery engine.

Radezolid is a late stage Phase 2 novel oxazolidinone designed to expand the bacterial spectrum and improve the utility of this class of antibiotics relative to the only other oxazolidinone marketed in the world, Zyvox® (linezolid). Additional programs include Rx-04, which employs a de novo approach to develop novel antibiotics that are active against multi-drug resistant Gram-negative bacteria and Rx-02, which is focused on engineering novel macrolides that have demonstrated activity against overcome known bacterial resistance mechanisms and have also demonstrated activity against methicillin-resistant Staphylococcus aureus.

Dr. Steitz, a Professor of Molecular Biophysics and Biochemistry at Yale University, was selected by the Nobel Prize Committee for his research on using X-ray crystallography to map the position for each and every one of the hundreds of thousands of atoms that make up the ribosome. Dr. Steitz focused on a subunit of the ribosome, which has proved to be a major target for antibiotics. By generating 3D models that show how different antibiotics bind to the ribosome, scientists can now develop new antibiotics.

About Thomas A. Steitz, Ph.D.

Born in Milwaukee, WI, Dr. Steitz received his Ph.D. in Molecular Biology and Biochemistry in 1966 from Harvard University. He was
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SOURCE Rib-X Pharmaceuticals, Inc.
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