Navigation Links
Revalesio Presents Data Showing RNS60 Alters Disease Progression in Animal Model of Alzheimer's Disease Through the PI3k-Akt Pathway
Date:7/18/2013

TACOMA, Wash., July 18, 2013 /PRNewswire/ -- On Wednesday Revalesio Corporation presented new data at the Alzheimer's Association International Conference that identifies the specific cellular pathways by which Revalesio's lead investigational product, RNS60, impacts Alzheimer's Disease. This research, conducted in partnership with Rush University Medical Center, investigates a new category of therapeutics using Revalesio's novel nanotechnology platform.

Data presented at the conference demonstrated RNS60's ability to prevent memory loss and improve learning through the PI3k-pAKT pathway.  Additionally, RNS60 upregulates critical genes associated with neuronal plasticity.  These genes play a key role in healthy neurotransmitter and synaptic function, foundational activities of the brain. 

Defining RNS60's activity against these genes is an important link between the significant therapeutic activity demonstrated by RNS60 in mouse and cellular models where RNS60 prevented beta-amyloid induced cell death and tau-neurofibrillary tangles – the most common hallmarks of Alzheimer's disease.

"The ability to define RNS60's biological activity to these plasticity associated genes and the PI3k-pAKT-CREB-BDNF pathway is an important event for the company," said Dr. Richard Watson, Revalesio's Chief Science Officer.  "We have a large and expanding data set on RNS60's ability to reduce inflammation, and these findings are a significant advancement in our understanding of how RNS60 may be a treatment for neuro-degenerative diseases."

These plasticity associated genes and associated pathways have long been targets for drug developers, but Revalesio's approach through its charge-stabilized nanostructure technology provides a new paradigm for treating Alzheimer's disease.  Revalesio and its research partners at Rush University Medical Center have submitted the data fo
'/>"/>

SOURCE Revalesio Corporation
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2

Related medicine technology :

1. Dr. Helen Fisher to Speak at Astellas Presents Executive Womens Day at the Constellation SENIOR PLAYERS Championship
2. Molly Fletcher to Speak at Astellas Presents Executive Womens Day at the AT&T National
3. Lexicon Presents Data at the American Diabetes Association Meeting On Blood Pressure Reduction and Weight Loss In Clinical Trial of LX4211
4. Lexicon Presents Preclinical Data On LX2761, a New Clinical Candidate for Diabetes Designed to Reduce Glucose Absorption From Gastrointestinal Tract
5. Nektar Therapeutics Presents Positive Data from Human Abuse Liability Study for NKTR-181, a First-in-Class Investigational Opioid to Treat Chronic Pain, at 2013 Annual Meeting of The College on Problems of Drug Dependence
6. Pharma IQ Presents the Latest Trends in Clinical Trial Supply
7. Adamas Pharmaceuticals Presents Positive Phase 2/3 Results For ADS-5102 For The Treatment Of Levodopa-Induced Dyskinesia (LID) In Parkinsons Disease
8. Vanda Presents Data From Phase III Studies that Demonstrate Tasimelteon Restores Daily Cortisol Rhythm In Blind Patients With Non-24-Hour Disorder
9. AbbVie Presents Preliminary Results from Phase I Study of Investigational Oncology Compound ABT-199/GDC-0199 in Patients with High-Risk Chronic Lymphocytic Leukemia (CLL) at European Hematology Association Annual Meeting
10. Bluestar Silicones Presents Elastomer Solutions At Medical Design And Manufacturing (MD&M) East Show
11. Discovery Labs Presents Final Assessment in a Series of Pharmacoeconomic Analyses that Explore Impact of Reintubation on Healthcare Costs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2014)... 15, 2014 Reportlinker.com announces that a ... its catalogue: PharmaPoint: ... Market Analysis to 2022 ... - India Drug Forecast and Market Analysis ...
(Date:1/15/2014)...  Zafgen, Inc., a leading biopharmaceutical company dedicated to ... today announced initial results from its Phase 2a ... aminopeptidase 2 (MetAP2), in patients with Prader-Willi syndrome ... results showed improvements in body weight, hunger-related behaviors, ...
(Date:1/14/2014)... Jan. 14, 2014 InformEx, North America,s ... high-value chemistry, will hold the 30 th edition of ... Convention Center from January 21-24. (Logo: ... top pharmaceutical, fine chemical and specialty chemical companies will take ...
Breaking Medicine Technology:PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 2PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 3PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 4PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 5Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 2Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 3Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 4Media Advisory: InformEx 2014 Events & Speaker Lineup for 30th Edition Conference in Miami Beach 2
... , ... Therapeutics, Inc. (PTC) today announced the initiation of an additional ... with nonsense mutation Duchenne/ Becker muscular dystrophy (nmDBMD) who ... is evaluating the best methods for measuring functional abilities in ...
... , VENLO, The Netherlands , Jan. 18 ... by the Lancet Oncology found that testing for high-risk types ... invasive cervical cancer than cytology (Pap testing) alone. The trial used QIAGEN,s ... HC2 HPV DNA Test), which detects the high-risk types of HPV that ...
Cached Medicine Technology:PTC Therapeutics Announces Additional Study of Ataluren in Patients with Advanced Nonsense Mutation Duchenne/Becker Muscular Dystrophy 2PTC Therapeutics Announces Additional Study of Ataluren in Patients with Advanced Nonsense Mutation Duchenne/Becker Muscular Dystrophy 3PTC Therapeutics Announces Additional Study of Ataluren in Patients with Advanced Nonsense Mutation Duchenne/Becker Muscular Dystrophy 4PTC Therapeutics Announces Additional Study of Ataluren in Patients with Advanced Nonsense Mutation Duchenne/Becker Muscular Dystrophy 5PTC Therapeutics Announces Additional Study of Ataluren in Patients with Advanced Nonsense Mutation Duchenne/Becker Muscular Dystrophy 6Study Demonstrates Value of HPV Screening to Prevent Invasive Cervical Cancer 2Study Demonstrates Value of HPV Screening to Prevent Invasive Cervical Cancer 3Study Demonstrates Value of HPV Screening to Prevent Invasive Cervical Cancer 4Study Demonstrates Value of HPV Screening to Prevent Invasive Cervical Cancer 5Study Demonstrates Value of HPV Screening to Prevent Invasive Cervical Cancer 6
(Date:4/16/2014)... 15, 2014 The Translational Genomics Research Institute (TGen) ... Founders Dinner for their support of TGen,s research into ... March 28 in Scottsdale. , Catherine Ivy, Founder and ... TGen,s John S. McCain Leadership Award, named for U.S. ...
(Date:4/16/2014)... While it is well known that fertility treatments are ... that multiples are at elevated risk of premature birth, ... Fertility and Sterility . The article ... reduce the odds of multiple births and prematurity, including ...
(Date:4/15/2014)... a recent analysis by the RECIST Working Group published in ... explored whether a more refined categorization of tumor response or ... in the RECIST database. They found that modeling target ... survival above and beyond that of the other components of ...
(Date:4/14/2014)... Ford Hospital reached a medical milestone April 3, performing ... way to access the heart. , Henry Ford is ... unique procedure called transcaval valve replacement, which accesses the ... Michigan resident Viola Waller, 80, underwent Henry Ford,s first ...
(Date:4/14/2014)... treatment decisions leaves cancer patients feeling more satisfied with ... the experience, researchers from the Perelman School of ... the journal Cancer . , In a study ... MD , an associate professor in the department in ...
Breaking Medicine News(10 mins):Health News:TGen honors Catherine Ivy and Craig Jackson with Leadership; Collaborative Spirit awards 2Health News:Preterm births, multiples, and fertility treatment 2Health News:Preterm births, multiples, and fertility treatment 3Health News:Can refined categorization improve prediction of patient survival in RECIST 1.1? 2Health News:Henry Ford Hospital hits new heart valve surgery milestone 2Health News:Shared decision making during radiation therapy improves patient satisfaction 2Health News:Shared decision making during radiation therapy improves patient satisfaction 3
... Day (Dec 1), India will launch a new scheme to ... Anbumani Ramadoss said here Monday. // ,"On Nov 30, ... treatment for children using paediatric anti-retroviral (ARV) drugs. We have ... four pharmaceutical companies are part of the process," Ramadoss told ...
... the United Kingdom concluded that the UK's National Health ... least// for now. The review was published in the ... series of the Health Technology Assessment Programme, part of ... Kingdom. ,An implantable pump can help heart ...
... indicates future heart problems, according to a study.,This research ... Journal of the American College of Cardiology. ... having a heart attack are at greater risk for ... depression-related screening protocols and treatment strategies. ,Known ...
... a familiar giant. Smokers around the world find it hard ... buy time by assuming that, cutting// down on the number ... latest research disagrees. ,A study published by ‘Tobacco Control’ ... number of cigarettes you smoke or continue to smoke 15 ...
... Pharma Ltd, based in Hyderabad, India, has announced the launch ... treat certain types of lung cancer. A very costly// preparation, ... imported version of the same medication, costs a whopping Rs ... first ever generic version of Pemetrexed, in the global arena. ...
... system has been developed that surpasses mammography in detecting ... had developed the system and the// University has licensed ... to make, use and sell the scanners. The National ... the Development. ,While commenting on the new ...
Cached Medicine News:Health News:Free HIV Treatment to Be Launched for Children 2Health News:Review Urges Restricted Use Of Devices To Keep Heart Patients Alive 2Health News:Review Urges Restricted Use Of Devices To Keep Heart Patients Alive 3Health News:Depression After Heart Attack Means More Heart Problems 2Health News:Depression After Heart Attack Means More Heart Problems 3Health News:For Smokers Only: is Quitting = Cutting Down?? a 'grave' Issue 2Health News:New Imaging System Surpasses Mammography In Detecting Breast Cancer 2
... From the Pioneer in Digital EEG ... Digital EEG system presents the latest ... the Ceegraph VISION. This innovative system ... remote communications and information management to ...
"Ganzfeld" stimulations for flash VEP, flash ERG and sensory EOG. Complies with international standards of electrophysiology....
The field of application of the SL 120 Slit Lamp extends from the anterior ocular segment and the vitreous right back to the fundus. It is the ideal configuration for observation, measurement, diagno...
Lens Loading and Folding for Multipiece & Single-Piece ACRYSOF Lens with Standard Forceps...
Medicine Products: