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Retrospective analysis of linagliptin data in sub-populations with type 2 diabetes presented at AACE 22nd Annual Scientific & Clinical Congress
Date:5/6/2013

RIDGEFIELD, Conn. and INDIANAPOLIS, May 6, 2013 /PRNewswire/ -- Boehringer Ingelheim Pharmaceuticals, Inc. and Eli Lilly and Company (NYSE: LLY) today announced results from two new pooled analyses of phase III data with the dipeptidyl peptidase-4 (DPP-4) inhibitor linagliptin, presented at the American Association of Clinical Endocrinologists (AACE) 22nd Annual Scientific & Clinical Congress.

In one retrospective pooled analysis, data were included from Hispanic/Latino adults with type 2 diabetes (T2D), a population that is disproportionately affected by T2D.1 Data pooled from six phase III studies showed that treatment with linagliptin reduced glucose levels (HbA1c) versus placebo in this patient population.

In a second retrospective analysis, data were pooled from two phase III studies that included people with long-standing T2D (>/=10 years).  The analysis showed reductions in HbA1c from baseline with linagliptin versus placebo. 

"Response to treatment can vary between sub-populations of adults with type 2 diabetes," said Christophe Arbet-Engels , MD, PhD, vice president, clinical development and medical affairs metabolic, Boehringer Ingelheim Pharmaceuticals, Inc. "Those with long-standing type 2 diabetes or of Hispanic/Latino origin are often difficult to treat or under-treated."

About Poster No. 1118 - Sub-population of Hispanic/Latino Adults with T2D
The findings from the first presentation were derived from six randomized, double-blind, placebo-controlled phase III studies of linagliptin 5 mg/d given as monotherapy or in addition to common glucose-lowering therapies.1 Of the six studies included in the analysis, two were 18 weeks in duration and four were 24 weeks in duration.1'/>"/>

SOURCE Eli Lilly and Company; Boehringer Ingelheim
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