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Retrospective Study Suggests that Stereotactic Ablative Radiotherapy (SABR) Can be a Viable Option for Treating Early-Stage Lung Cancer in Operable as well as Inoperable Patients; Phase III Randomized Trial Now Under Way
Date:5/1/2012

LAS VEGAS, May 1, 2012 /PRNewswire/ -- Noninvasive stereotactic ablative radiotherapy (SABR), a technical term for radiosurgery in the body, can be a viable option for treating operable cases of early-stage lung cancer, with outcomes that compare favorably to more invasive surgery, according to a study published in the May 2012 issue of the International Journal of Radiation Oncology, Biology, Physics.[1]

Speaking at a symposium sponsored by Varian Medical Systems (NYSE: VAR) in Las Vegas earlier this week, co-author Ben Slotman, M.D., Ph.D., of the VU University Medical Centre in Amsterdam reported that, for potentially operable patients with Stage I non-small cell lung cancer (NSCLC), SABR produced tumor control rates that are comparable to those achieved using surgery.   

Professor Slotman and his colleagues retrospectively reviewed records for lung cancer patients who were treated in his department between 2003 and 2010.  Among about 1,000 patients treated with SABR, the researchers identified 177 (101 males and 76 females) who could have been candidates for surgery but who instead received SABR.

"Among these patients, the one- and three-year survival rates were 95 percent and 85 percent respectively," said Dr. Slotman.  "The local tumor control rate after three years was 93 percent, and the median overall survival time was 61.5 months.  No patients died in the first 30 days after treatment.  Had these patients been treated surgically, we would have expected a 2.6 percent mortality rate, based on the Thoracoscore predictive model."[2]

Forty-two percent of patients in the study reported no early side effects with the SABR treatments. Those that did experience early side-effects experienced fatigue (25 percent), cough (14 percent), local chest wall pain (11 percent) and dyspnea (10 percent), with some patient
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SOURCE Varian Medical Systems, Inc.
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