Navigation Links
Resveratrol Longevity Science Makes Dramatic U-Turn, But Resveratrol Supplements Remain Unchanged
Date:9/10/2008

sume about 35% fat calories). The fat-engorged mice did live longer on resveratrol, but this experiment is not comparable to humans eating a normal diet. [Resveratrol improves health and survival of mice on a high-calorie diet. Nature 2006 Nov 16; 444(7117):337-42]

The Sirtuin1 gene does not appear to be the "holy grail" of longevity by itself, as once claimed. The Sirtuin family of genes works in tandem with other genes, such as FOXO1 and PGc1alpha. [Interaction of aging-associated signaling cascades: inhibition of NF-kappaB signaling by longevity factors Foxos and SIRT1. Cell Mol Life Science. 2008 Apr; 65(7-8):1049-58; Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation. Proceedings National Academy of Science: 2005 Aug 9; 102(32):11278-83]

Nor does a singular molecule such as resveratrol appear to work as well as resveratrol combined with quercetin or other small molecules. [Combined resveratrol, quercetin, and catechin treatment reduces breast tumor growth in a nude mouse model. Translational Oncology 2008 March; 1(1):19-27; Enhanced inhibition of adipogenesis and induction of apoptosis in 3T3-L1 adipocytes with combinations of resveratrol and quercetin. Life Science 2008 May 7; 82(19-20):1032-9]

Sardi says other key genes, particularly the FOXO1 gene, which plays a key role in a variety of biological processes, including metabolism, cell proliferation, and oxidative stress response, may play a stronger role than the Sirtuin1 gene in producing longevity.

At the National Library of Medicine online there are now 706 published journal reports on FOXO1, and 471 on Sirtuin1. In the gene array study published in the September 2008 issue of Experimental Gerontology, only Longevinex(R), and not calorie restriction of plain resveratrol, activated the FOXO1 gene.

Longevinex(R) has since abandoned the Sirtuin1 gene activation test as a measure of dietary supplement activity. In the Longevinex(R) mouse s
'/>"/>

SOURCE Resveratrol Partners, LLC
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Video: Resveratrol-based Nutriceutical (Longevinex(R)) Induces Favorable Changes on Gene Expression in Mouse Heart At Doses 17-320 Times Lower Than Prior Studies
2. Epiphany Biosciences to Continue Phase 2 Shingles Study After Interim Analysis; Plans Follow-On Clinical Trial Studying Post-Herpetic Neuralgia (PHN)
3. Ardea Biosciences to Present Data on Lead MEK Inhibitor, RDEA119, at American College of Gastroenterology Annual Scientific Meeting
4. Sangamo BioSciences Initiates Phase 2 Clinical Trial of Treatment for Amyotrophic Lateral Sclerosis (ALS)
5. Neurocrine Biosciences Announces Successful Elagolix PETAL Study in Endometriosis
6. Human Genome Sciences Reports Initial Results of Randomized Phase 2 Trial of HGS-ETR1 in Combination With Bortezomib in Advanced Multiple Myeloma
7. Regado Biosciences Reports Clinical Results for REG1 Anticoagulation System at European Society of Cardiology Congress 2008
8. Stem Cell Sciences Announces the Creation of the Worlds First Authentic Rat Embryonic Stem Cells from its Exclusively Licensed Technology
9. Neurosciences Institute Discovers Drug Extends Stroke Treatment Time to 24 Hours, Repairs Brain Tissue
10. Human Genome Sciences Completes Enrollment in Second Phase 3 LymphoStat-B(R) Trial
11. Human Genome Sciences Completes Enrollment in Randomized Phase 2 Trial of HGS-ETR1 in Non-Small Cell Lung Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/2/2015)... Utah , March 2, 2015  BC ... Imaging Solutions, has acquired Eclipse Systems, a Nuclear ... service solutions. As part of their ongoing vision ... at an affordable rate, BC Technical continues to ... allows BC Technical to add valuable resources and ...
(Date:3/2/2015)... GERMANTOWN, Md., March 2, 2015  Intrexon Corporation ... synthetic biology, today announced its fourth quarter and ... Business Highlights and Recent Developments: , Acquired ... a new frontier in cellular therapeutics and other ... molecular engineering of food-grade microbes ( Lactococcus lactis ...
(Date:3/2/2015)... March 2, 2015 When someone gets sick, their ... a primary care physician or an urgent care facility ... the healthcare provided by doctors and medical professionals comes ... it,s not ideal in every circumstance. Though it may ... where occupants have higher chances of contracting illnesses. Also, ...
Breaking Medicine Technology:BC Technical Acquires Eclipse Systems 2Intrexon Announces Fourth Quarter and Full Year 2014 Financial Results 2Intrexon Announces Fourth Quarter and Full Year 2014 Financial Results 3Intrexon Announces Fourth Quarter and Full Year 2014 Financial Results 4Intrexon Announces Fourth Quarter and Full Year 2014 Financial Results 5Intrexon Announces Fourth Quarter and Full Year 2014 Financial Results 6Intrexon Announces Fourth Quarter and Full Year 2014 Financial Results 7Intrexon Announces Fourth Quarter and Full Year 2014 Financial Results 8Intrexon Announces Fourth Quarter and Full Year 2014 Financial Results 9Intrexon Announces Fourth Quarter and Full Year 2014 Financial Results 10Intrexon Announces Fourth Quarter and Full Year 2014 Financial Results 11Intrexon Announces Fourth Quarter and Full Year 2014 Financial Results 12Intrexon Announces Fourth Quarter and Full Year 2014 Financial Results 13Intrexon Announces Fourth Quarter and Full Year 2014 Financial Results 14Intrexon Announces Fourth Quarter and Full Year 2014 Financial Results 15Intrexon Announces Fourth Quarter and Full Year 2014 Financial Results 16Intrexon Announces Fourth Quarter and Full Year 2014 Financial Results 17Intrexon Announces Fourth Quarter and Full Year 2014 Financial Results 18Intrexon Announces Fourth Quarter and Full Year 2014 Financial Results 19Intrexon Announces Fourth Quarter and Full Year 2014 Financial Results 20Intrexon Announces Fourth Quarter and Full Year 2014 Financial Results 21Intrexon Announces Fourth Quarter and Full Year 2014 Financial Results 22Intrexon Announces Fourth Quarter and Full Year 2014 Financial Results 23Intrexon Announces Fourth Quarter and Full Year 2014 Financial Results 24House Call Medicine Helps Patients Receive Treatment While Avoiding the Hassles and Potential Risks of an Urgent Care Facility 2
... VIEW, Calif., Dec. 3, 2010 VIVUS, Inc. ... senior management will present an overview of the ... of December.The conference presentation schedule is as follows:Canaccord ... at 12:30 p.m. PTNikko Hotel, San Francisco, CAPresenter: ...
... MOUNTAIN VIEW, Calif., Dec. 3, 2010 Omnicell, ... provider of medication management solutions to acute healthcare facilities, ... American Society for Health-System Pharmacists (ASHP) Midyear Clinical Meeting ...  New solutions being unveiled or previewed include the new ...
Cached Medicine Technology:Omnicell to Showcase Latest Product Innovations at ASHP 2Omnicell to Showcase Latest Product Innovations at ASHP 3Omnicell to Showcase Latest Product Innovations at ASHP 4Omnicell to Showcase Latest Product Innovations at ASHP 5
(Date:3/2/2015)... Ticket Down is a reputable source for ... This popular site has reduced all ticket prices and ... added savings. , Parrotheads in the Los Angeles area ... at the Hollywood Bowl for the first time since ... 22nd and it will be in conjunction with Buffett's ...
(Date:3/2/2015)... March 02, 2015 Doctors in Novara, ... a better predictor of outcomes for people with mesothelioma ... details of the new study on the Surviving ... the University of Eastern Piedmont followed the cases of ... treatment for excess lung fluid. , “Persistent lung ...
(Date:3/2/2015)... MN (PRWEB) March 02, 2015 ... temperature calibration for Secondary Standard Platinum Resistance ... in 5 business days or less . . ... NVLAP ® Accredited (Lab Code 200706-0), ISO ... traceability. Temperature range is -196°C to 500°C, ...
(Date:3/2/2015)... 2015 The minimally invasive surgical ... CAGR of 6.1% to reach $14,133.0 million by ... Factors such as advantages of minimally invasive surgeries ... to minimally invasive surgeries and increasing number of ... the global minimally invasive surgical instruments market. , ...
(Date:3/2/2015)... Hawaii (PRWEB) March 02, 2015 Four Seasons ... is celebrating its 25th anniversary this year, having officially opened ... milestone, the luxury resort is honoring over 70 employees who ... resort -- from amongst the approximately 400 original employees. ... the Resort’s Oceanfront Lawn. , This Four Seasons ...
Breaking Medicine News(10 mins):Health News:Cheap Jimmy Buffett Tickets Hollywood Bowl: Ticket Down Slashes Prices on Jimmy Buffett Tickets at the Hollywood Bowl in Los Angeles/Hollywood, CA 2Health News:New Research Links Talc Treatment Response with Mesothelioma Prognosis, According to Surviving Mesothelioma 2Health News:Burns Engineering Announces Quick-Turn Temperature Calibrations 2Health News:Minimally Invasive Surgical Instrument Market - Global Forecast to 2019 - New Report by MarketsandMarkets 2Health News:Celebrating Four Seasons Resort Maui’s 25th Anniversary 2
... ... Marriott, Neiman Marcus, Dell, and Home Depot. Is he right or wrong? ... (PRWEB) April 7, ... South Carolina’s Criminal Justice Academy’s annual Police Chiefs’ workshop this morning., , ,Chief Lance ...
... failed, trial results show , WEDNESDAY, April 7 (HealthDay ... second-round treatment for hepatitis cures about half the people ... research shows. , "This is the first large study ... said Dr. John G. McHutchison, associate director of the ...
... TriLipo ... body. Clinically proven, the maximus system powered by TriLipo, is a new medical system ... skin tightening. , ... Tel Aviv, Israel (PRWEB) April 7, 2010 - Pollogen Ltd , a ...
... Behavior may increase need for protection from sexually transmitted ... in nonromantic sexual relationships today are likely to have ... promote the spread of sexually transmitted diseases, they note. ... toward nonromantic sexual partnerships -- people becoming sexually involved ...
... An elderly woman suspected of having a stroke arrives confused ... she is able to provide to access the critical medical ... that,s the promise of health information technology. To move ... University of Texas Health Science Center at Houston (UTHealth) have ...
... prediction that due to the obesity epidemic Baby Boomers may ... University of Michigan Health System on obesity trends shows Americans ... longer periods over their lifetime. As a result, ... expectancy may be worse than previously thought. The findings will ...
Cached Medicine News:Health News:Are the Cops Now Competing With Disney? 2Health News:New Drug Shows Promise for Curing Hepatitis C 2Health News:New Drug Shows Promise for Curing Hepatitis C 3Health News:Pollogen Launches the Maximus, Advanced Solution for Fat Reduction and Body Shaping based on Innovative TriLipo Technology 2Health News:Pollogen Launches the Maximus, Advanced Solution for Fat Reduction and Body Shaping based on Innovative TriLipo Technology 3Health News:Casual Sex Increasing in U.S. 2Health News:UTHealth receives $15 million for health information technology research 2Health News:UTHealth receives $15 million for health information technology research 3Health News:UTHealth receives $15 million for health information technology research 4Health News:Getting heavier, younger: U-M study shows generational shift in obesity 2
... Urinalysis WorkCell System - A Single ... per hour, with true load-and-go productivity ... Clinitek Atlas and UF-100 for complete ... systems working together deliver utmost reliability. ...
... one of the 3 major naturally occurring ... In terms of estrogenic activity, estriol is ... is produced almost exclusively during pregnancy, and ... normal human fetus. During pregnancy, the production ...
... of the three major naturally-occurring estrogens. Other ... is produced primarily from androstenedione originating from ... In premenopausal adult women, more than 50% ... In prepubertal children, men and postmenopausal women, ...
... Estrone Enzyme Immunosorbent Assay (EIA) Kit ... of Estrone in serum. The procedure ... immunoassay where there is competition between ... antigen for a fixed number of ...
Medicine Products: