Navigation Links
Resveratrol Longevity Science Makes Dramatic U-Turn, But Resveratrol Supplements Remain Unchanged
Date:9/10/2008

sume about 35% fat calories). The fat-engorged mice did live longer on resveratrol, but this experiment is not comparable to humans eating a normal diet. [Resveratrol improves health and survival of mice on a high-calorie diet. Nature 2006 Nov 16; 444(7117):337-42]

The Sirtuin1 gene does not appear to be the "holy grail" of longevity by itself, as once claimed. The Sirtuin family of genes works in tandem with other genes, such as FOXO1 and PGc1alpha. [Interaction of aging-associated signaling cascades: inhibition of NF-kappaB signaling by longevity factors Foxos and SIRT1. Cell Mol Life Science. 2008 Apr; 65(7-8):1049-58; Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation. Proceedings National Academy of Science: 2005 Aug 9; 102(32):11278-83]

Nor does a singular molecule such as resveratrol appear to work as well as resveratrol combined with quercetin or other small molecules. [Combined resveratrol, quercetin, and catechin treatment reduces breast tumor growth in a nude mouse model. Translational Oncology 2008 March; 1(1):19-27; Enhanced inhibition of adipogenesis and induction of apoptosis in 3T3-L1 adipocytes with combinations of resveratrol and quercetin. Life Science 2008 May 7; 82(19-20):1032-9]

Sardi says other key genes, particularly the FOXO1 gene, which plays a key role in a variety of biological processes, including metabolism, cell proliferation, and oxidative stress response, may play a stronger role than the Sirtuin1 gene in producing longevity.

At the National Library of Medicine online there are now 706 published journal reports on FOXO1, and 471 on Sirtuin1. In the gene array study published in the September 2008 issue of Experimental Gerontology, only Longevinex(R), and not calorie restriction of plain resveratrol, activated the FOXO1 gene.

Longevinex(R) has since abandoned the Sirtuin1 gene activation test as a measure of dietary supplement activity. In the Longevinex(R) mouse s
'/>"/>

SOURCE Resveratrol Partners, LLC
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Video: Resveratrol-based Nutriceutical (Longevinex(R)) Induces Favorable Changes on Gene Expression in Mouse Heart At Doses 17-320 Times Lower Than Prior Studies
2. Epiphany Biosciences to Continue Phase 2 Shingles Study After Interim Analysis; Plans Follow-On Clinical Trial Studying Post-Herpetic Neuralgia (PHN)
3. Ardea Biosciences to Present Data on Lead MEK Inhibitor, RDEA119, at American College of Gastroenterology Annual Scientific Meeting
4. Sangamo BioSciences Initiates Phase 2 Clinical Trial of Treatment for Amyotrophic Lateral Sclerosis (ALS)
5. Neurocrine Biosciences Announces Successful Elagolix PETAL Study in Endometriosis
6. Human Genome Sciences Reports Initial Results of Randomized Phase 2 Trial of HGS-ETR1 in Combination With Bortezomib in Advanced Multiple Myeloma
7. Regado Biosciences Reports Clinical Results for REG1 Anticoagulation System at European Society of Cardiology Congress 2008
8. Stem Cell Sciences Announces the Creation of the Worlds First Authentic Rat Embryonic Stem Cells from its Exclusively Licensed Technology
9. Neurosciences Institute Discovers Drug Extends Stroke Treatment Time to 24 Hours, Repairs Brain Tissue
10. Human Genome Sciences Completes Enrollment in Second Phase 3 LymphoStat-B(R) Trial
11. Human Genome Sciences Completes Enrollment in Randomized Phase 2 Trial of HGS-ETR1 in Non-Small Cell Lung Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2015)... , Aug. 28, 2015 ... has announced the addition of the "Investigation ... to their offering. Developed by Pharmacia ... prostaglandin receptor agonist which effectively reduces intraocular pressure. ... FDA, latanoprost (under the trade name of Xalatan) ...
(Date:8/28/2015)... Aug. 28, 2015 Perrigo Company plc ("Perrigo") ... Mylan N.V. ("Mylan") (NASDAQ: MYL ) shareholder vote ... "Our views of Mylan,s offer to Perrigo shareholders ... on our Board,s careful reflection of the value available ... limited choices that Mylan has allowed its shareholders to ...
(Date:8/28/2015)... , Joint research by Prof. Kim ... , Published in ,Stem Cells Translational Medicine, (IF ... multiple IV administration of Adipose-derived MSC , Increase ... , Commercialization within 5 years expected ... adult mesenchymal stem cells (MSCs) may extend healthy life ...
Breaking Medicine Technology:China Latanoprost Market Investigation Report 2015-2019 2Perrigo Confident Its Shareholders Will Reject Mylan's Value Destructive Transaction 2Perrigo Confident Its Shareholders Will Reject Mylan's Value Destructive Transaction 3Perrigo Confident Its Shareholders Will Reject Mylan's Value Destructive Transaction 4Perrigo Confident Its Shareholders Will Reject Mylan's Value Destructive Transaction 5Korean Researchers Find the Possibility that Adult Mesenchymal Stem Cells (MSCs) May Extend Lifespan 2
(Date:8/28/2015)... Tempe, AZ (PRWEB) , ... August 29, 2015 , ... ... to reinvent higher learning and the student experience as part of the EDUCAUSE - ... Melinda Gates Foundation . , This is the third Breakthrough Models Incubator ...
(Date:8/28/2015)... (PRWEB) , ... August 28, 2015 , ... An ... that local pizza maker Paul LaRocco has gone through to open a pizzeria in ... and permitting process tends to take several months, but the current process, having already ...
(Date:8/28/2015)... MA (PRWEB) , ... August 28, 2015 , ... The ... benefitting the renowned Brain Aneurysm Foundation has added yet another accolade to its cadre ... Rahm Emanuel. , “With the help of the medical community and the ...
(Date:8/28/2015)... , ... August 28, 2015 , ... ... Library for documenting and diagramming network and data center assets and audio-video devices, ... Device Model, Cisco Nexus 5000 Series, HP ProLiant Gen9, EMC VNX Series , ...
(Date:8/28/2015)... (PRWEB) , ... August 28, 2015 , ... Dr. Gregory ... such as radiating pain resulting in shoulder pain, hip pain, neck pain, ... in Civil Engineering from the University of Illinois, and then went on to earn ...
Breaking Medicine News(10 mins):Health News:Rio Salado College Joins 9 Educational Leaders to Reinvent Higher Learning 2Health News:Rio Salado College Joins 9 Educational Leaders to Reinvent Higher Learning 3Health News:Rio Salado College Joins 9 Educational Leaders to Reinvent Higher Learning 4Health News:Article on Building Approval Process for LA Business Highlights the Need for a Bridge Between Businesses and City Officials, says Fire Protection Group Inc. 2Health News:Chicago Mayor Pens Official Support of Annual Survivor in the City Event Benefitting Brain Aneurysm Foundation 2Health News:Chicago Mayor Pens Official Support of Annual Survivor in the City Event Benefitting Brain Aneurysm Foundation 3Health News:Altima Updates NetZoom™ Visio® Stencil Library for Cisco, HP, and EMC Devices 2Health News:Altima Updates NetZoom™ Visio® Stencil Library for Cisco, HP, and EMC Devices 3Health News:Healthpointe Welcomes Dr. Gregory K. Toumayan, Chiropractor, to Colton, Temecula, and Perris 2Health News:Healthpointe Welcomes Dr. Gregory K. Toumayan, Chiropractor, to Colton, Temecula, and Perris 3
... Oct. 29 Irvine Pharmaceutical Services,Inc., announced today that ... current and future industry demands, the company has promoted ... and added,to its staff Chief Operating Officer Greg McParland. ... growth as it gears up to launch its new,subsidiary, ...
... 29 Nu Skin Enterprises,Inc. (NYSE: NUS ... the,quarter of $310.3 million, a 7 percent improvement ... a 26 percent improvement over the,same quarter of ... 2,percent by foreign currency fluctuations and earnings per ...
... acquire US rights in tesamorelin, a Phase III compound ... HIV patients with lipodystrophy -- ... royalties on net sales in the US -- Merck KGaA, ... make equity investment in Theratechnologies -- EMD ...
... Use IPL to Clear Acne Blemishes, COSTA ... the CLARO acne-clearing device received marketing clearance by,the ... of mild to moderate,inflammatory acne. CLARO, the first ... treatment of acne, will be available by prescription,January ...
... of crafting smiles for Californians, Ron Greenspan, DDS, has been selected for ... the Washington, D.C. based U.S. Local Business Association (USLBA). , ... San ... smiles for Californians, Ron Greenspan, DDS, has been selected for the 2008 ...
... and increasing concerns for oral hygiene are considered the main factors contributing ... projected to reach $12.7 billion by the year 2012. , ... San ... one of the most dynamic segments of the oral care market. The ...
Cached Medicine News:Health News:Irvine Pharmaceutical Services Enhances Staff, Prepares for Innovative Expansion 2Health News:Nu Skin Enterprises Reports Third-Quarter 2008 Results 2Health News:Nu Skin Enterprises Reports Third-Quarter 2008 Results 3Health News:Nu Skin Enterprises Reports Third-Quarter 2008 Results 4Health News:Nu Skin Enterprises Reports Third-Quarter 2008 Results 5Health News:Nu Skin Enterprises Reports Third-Quarter 2008 Results 6Health News:Nu Skin Enterprises Reports Third-Quarter 2008 Results 7Health News:Nu Skin Enterprises Reports Third-Quarter 2008 Results 8Health News:Nu Skin Enterprises Reports Third-Quarter 2008 Results 9Health News:Nu Skin Enterprises Reports Third-Quarter 2008 Results 10Health News:Nu Skin Enterprises Reports Third-Quarter 2008 Results 11Health News:EMD Serono and Theratechnologies Announce Collaboration and Licensing Agreement for Tesamorelin in the United States 2Health News:EMD Serono and Theratechnologies Announce Collaboration and Licensing Agreement for Tesamorelin in the United States 3Health News:EMD Serono and Theratechnologies Announce Collaboration and Licensing Agreement for Tesamorelin in the United States 4Health News:EMD Serono and Theratechnologies Announce Collaboration and Licensing Agreement for Tesamorelin in the United States 5Health News:CLARO Receives FDA-Clearance for Treatment of Acne 2Health News:Dr. Ron Greenspan has Been Selected for the 2008 Best of San Diego Award in the Orthodontists Category by the U.S. Local Business Association 2Health News:Dr. Ron Greenspan has Been Selected for the 2008 Best of San Diego Award in the Orthodontists Category by the U.S. Local Business Association 3Health News:Global Toothpaste Market to Reach $12.7 Billion by 2012, According to a New Report by Global Industry Analysts, Inc. 2Health News:Global Toothpaste Market to Reach $12.7 Billion by 2012, According to a New Report by Global Industry Analysts, Inc. 3
... III DLE (Drug List Editor) Multi-Channel Infusion ... infusion technology. The instrument combines three independent ... versatility in an unparalleled small size. Now ... III Infusion System simplifies the delivery of ...
... The Gemini Family of infusion ... with a collective series of ... product line offers a wide ... IV sets, each featuring the ...
... first steps any hospital or health system ... powerful, most effective tools available for physicians ... clinician documentation and electronic medical record (EMR) ... this goal. In fact, its the most ...
... specialty Eraser instruments have been designed ... the right tool for situations requiring ... series of 25 gauge intraocular, bipolar, ... treatment of target tissues for fine-tip ...
Medicine Products: