Navigation Links
Resveratrol Longevity Science Makes Dramatic U-Turn, But Resveratrol Supplements Remain Unchanged
Date:9/10/2008

000-fold or more, actual studies with warm-blood mammals showed over-activation of the Sirtuin1 gene increases the occurrence of heart failure by more than 7.5 fold. [Sirt1 regulates aging and resistance to oxidative stress in the heart. Circulation Research 2007; 100: 1512-21]

-- While it was initially believed only mega-dose resveratrol would be effective, and that strong Sirtuin1 gene activators would be required, a much lower dose of resveratrol (100 milligrams human equivalent of trans resveratrol, 4 to 320 times lower than previous studies, when provided in a patent-applied for matrix of other small molecules), exerted a 9-fold greater genomic effect than plain resveratrol or a calorie-restricted diet. In this study, calorie restriction significantly differentiated (up or down-regulated) 198 genes, and resveratrol, its molecular mimic, significantly influenced 225 genes, while resveratrol-based matrix (Longevinex(R)) significantly differentiated 1711 genes. [Short-term consumption of a resveratrol-containing nutraceutical mixture mimics gene expression of long-term caloric restriction in mouse heart. Experimental Gerontology 2008 Sep;43(9):859-66]

Sardi says websites selling resveratrol supplements still parrot earlier but now outdated news reports about Sirtuin1 genes and mega-doses appear oblivious to the striking changes in resveratrol science that have been recently published. "Paying heed to the current data now available, mega-dose resveratrol is ill-advised and may be related to uncommon but reported side effects, namely Achilles heel tendon inflammation, skin rash, joint stiffening, flu-like symptoms and numbness in fingertips, all which are reversible," says Sardi.

Some marketers of resveratrol supplements still misguidedly refer to the 2006 study published in Nature Magazine where mice lived longer on a resveratrol-fed diet, but these mice were fed a 60% fat-calorie diet which could not possibly be achieved by humans. (Humans con
'/>"/>

SOURCE Resveratrol Partners, LLC
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Video: Resveratrol-based Nutriceutical (Longevinex(R)) Induces Favorable Changes on Gene Expression in Mouse Heart At Doses 17-320 Times Lower Than Prior Studies
2. Epiphany Biosciences to Continue Phase 2 Shingles Study After Interim Analysis; Plans Follow-On Clinical Trial Studying Post-Herpetic Neuralgia (PHN)
3. Ardea Biosciences to Present Data on Lead MEK Inhibitor, RDEA119, at American College of Gastroenterology Annual Scientific Meeting
4. Sangamo BioSciences Initiates Phase 2 Clinical Trial of Treatment for Amyotrophic Lateral Sclerosis (ALS)
5. Neurocrine Biosciences Announces Successful Elagolix PETAL Study in Endometriosis
6. Human Genome Sciences Reports Initial Results of Randomized Phase 2 Trial of HGS-ETR1 in Combination With Bortezomib in Advanced Multiple Myeloma
7. Regado Biosciences Reports Clinical Results for REG1 Anticoagulation System at European Society of Cardiology Congress 2008
8. Stem Cell Sciences Announces the Creation of the Worlds First Authentic Rat Embryonic Stem Cells from its Exclusively Licensed Technology
9. Neurosciences Institute Discovers Drug Extends Stroke Treatment Time to 24 Hours, Repairs Brain Tissue
10. Human Genome Sciences Completes Enrollment in Second Phase 3 LymphoStat-B(R) Trial
11. Human Genome Sciences Completes Enrollment in Randomized Phase 2 Trial of HGS-ETR1 in Non-Small Cell Lung Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/30/2015)... , April 30, 2015  Accuray Incorporated ... has signed an agreement with MIM Software Inc. ... TomoTherapy ® and CyberKnife ® product portfolios. ... and MIM technology. This is Accuray,s second collaboration ... development of the first iPad-based treatment plan review ...
(Date:4/30/2015)... DIEGO, April 30, 2015  Tandem Diabetes Care ® , ... manufacturer of the t:slim ® and t:flex™ Insulin Pumps, ... 31, 2015. In comparing the first quarter ... Sales grew 53 percent to $12.3 million from $8.1 million ... pumps from 1,723 pumps "Our investment in resources ...
(Date:4/30/2015)...   Regulus Therapeutics Inc . (NASDAQ: RGLS ... of innovative medicines targeting microRNAs, today announced that it ... ended March 31, 2015 on Thursday, May 7, 2015, ... Regulus will host a conference call and webcast on ... Time to discuss its first quarter 2015 financial results ...
Breaking Medicine Technology:Accuray Signs Agreement with MIM Software Inc. to Develop Adaptive Therapy Software 2Accuray Signs Agreement with MIM Software Inc. to Develop Adaptive Therapy Software 3Tandem Diabetes Care Reports First Quarter 2015 Financial Results 2Tandem Diabetes Care Reports First Quarter 2015 Financial Results 3Tandem Diabetes Care Reports First Quarter 2015 Financial Results 4Tandem Diabetes Care Reports First Quarter 2015 Financial Results 5Tandem Diabetes Care Reports First Quarter 2015 Financial Results 6Regulus Announces Timing for First Quarter 2015 Financial Results Webcast and Conference Call 2Regulus Announces Timing for First Quarter 2015 Financial Results Webcast and Conference Call 3
... 2011 /PRNewswire-Asia/ -- Pharmaceutical company Hatchtech Pty Ltd has ... study to confirm the efficacy of its novel head ... is evaluating the efficacy, safety and tolerability of two ... to vehicle. The trial consists of treating 132 healthy ...
... Aug. 31, 2011 Onyx Pharmaceuticals, Inc. (Nasdaq: ... appointed Helen Torley, M.B. Ch. B., M.R.C.P.,  as Executive ... Dr. Torley will report to N. Anthony Coles, M.D., ... for all commercial activities related to Nexavar and the ...
Cached Medicine Technology:Hatchtech Completes Treatment Phase of 2b Clinical Trial of New-Generation Head Lice Treatment Deovo™ 2Hatchtech Completes Treatment Phase of 2b Clinical Trial of New-Generation Head Lice Treatment Deovo™ 3Onyx Pharmaceuticals Appoints Dr. Helen Torley as Chief Commercial Officer 2Onyx Pharmaceuticals Appoints Dr. Helen Torley as Chief Commercial Officer 3
(Date:5/2/2015)... 02, 2015 On Tuesday April 7th, ... (ELCH) gathered to celebrate improvements in patient care. In ... Partners (RVHP), had zero acquired ventilator associated infections, zero ... infections. ELCH was also recently named a Top Performer ... at ELCH credited the teamwork of staff from all ...
(Date:5/2/2015)... ZoomCare, the Portland-based innovator of on-demand healthcare ... its new healthcare insurance to individuals and small businesses ... System is the nation’s first health insurance system built ... Personal Health Insurance was ZoomCare’s first such filing including ... to review and regulation by the Oregon Insurance Division. ...
(Date:5/1/2015)... Caicos Islands, BWI (PRWEB) May 02, 2015 ... website! It is http://www.thevenetiangracebay.com , and it ... it incorporates the stunning white and attractive turquoise hues ... study of Google, sixty seven percent of leisure travelers ... study showed that smartphones were used in the planning ...
(Date:5/1/2015)... 01, 2015 Royal River Natural Foods, ... reports on a new study that found two natural ... and improved physical function as well as standard drug ... of the knee. , The report is part of ... Well Being® ,” which Royal River Natural Foods publishes ...
(Date:5/1/2015)... DC (PRWEB) May 01, 2015 It’s raining ... and House introducing proposals to expand federal support for telemedicine. ... years that ATA has been working with Congress,” said Jonathan ... actions signify how the nation is poised to embrace the ... is one more step in fulfilling ATA’s mission to improve ...
Breaking Medicine News(10 mins):Health News:East Liverpool City Hospital Celebrates Patient Care Improvements 2Health News:ZoomCare Applies to be on Oregon Exchange 2Health News:Turks and Caicos Resort, The Venetian on Grace Bay, Launches New Web Presence 2Health News:New Study Finds Nutrients Ease Arthritis Pain, Retailer Reports 2Health News:ATA: Congress Floods the Halls with Telemedicine Proposals 2
... demonstrated their,desire to be good neighbors during Aurora Health Care,s ... throughout eastern Wisconsin. , ... the event Saturday. The items were brought by nearly 1,200,residents ... clinics. , Good Neighbor ...
... 18 Capital BlueCross received the,2008 Corporation of the ... of Fundraising Professionals during a celebration of National,Philanthropy Day ... daily,contributions made by corporations, individuals, foundations and volunteers. , ... headquartered in central Pennsylvania, Capital BlueCross,remains part of the ...
... scientists, Wound-Be-Gone is now the only over the counter treatment for ... technology that both prevents contamination of wounds and speeds up the ... ... --- Now, with the development of Wound-Be-Gone, all skin injuries, especially ...
... anti-disease effect in postmenopausal women, study says , , TUESDAY, ... found out why diet and exercise affect a women,s ... new study says. , Researchers at the University ... exercise affect pathways to mTOR, a molecule that integrates ...
... nontoxic nanoparticle developed by Penn State researchers is proving ... therapeutic drugs and the fluorescent dyes that can track ... Nano Letters , an interdisciplinary group of materials ... phosphate particles ranging in size from 20 to 50 ...
... FRANCISCO, Nov. 18 State Compensation Insurance Fund,today announced it ... business disruption caused by the fires in Montecito, Orange,County and ... more than 900 residences and structures have been lost due ... untold number of businesses,have suffered damages. , ...
Cached Medicine News:Health News:Eastern Wisconsin Residents Demonstrate Their Commitment to Being Good Neighbors 2Health News:Eastern Wisconsin Residents Demonstrate Their Commitment to Being Good Neighbors 3Health News:Capital BlueCross Receives Prestigious Corporation of the Year Award 2Health News:A Revolution in Wound Healing, Wound-Be-Gone Now the Only Over the Counter Treatment for Chronic and Acute Wounds 2Health News:A Revolution in Wound Healing, Wound-Be-Gone Now the Only Over the Counter Treatment for Chronic and Acute Wounds 3Health News:Diet, Exercise May Modify Breast Cancer Risks 2Health News:Nontoxic nanoparticle can deliver and track drugs 2Health News:Nontoxic nanoparticle can deliver and track drugs 3
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: