Resveratrol Longevity Science Makes Dramatic U-Turn, But Resveratrol Supplements Remain...( Mega-dose Resveratrol Sirtuin1 gene ...),Health

Mega-dose Resveratrol, Sirtuin1 gene Target Discredited; Lower Dose, Array

of Small Molecules (Longevinex(R)) Exert Greater Effect

SAN DIMAS, Calif., Sept. 10 /PRNewswire/ -- While the red wine molecule resveratrol (rez-vair-ah-trawl) has recently attracted scientific and public attention as a longevity molecule that allegedly mimics the effects of a calorie-restricted diet, the science surrounding this molecule has taken a dramatic turn in recent months, according to Bill Sardi, spokesperson for Longevinex(R) (long-jev-in-ex), a major brand resveratrol supplement.

(Photo: http://www.newscom.com/cgi-bin/prnh/20080422/LATU004)

Published research studies now show:

-- Mice fed high-dose resveratrol did not live as long as mice fed a plain standard calorie diet. Animals on the lower dose (360 milligram human equivalent) lived longer than those on the higher dose (1565 mg) of resveratrol. [Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span. Cell Metabolism 2008 Aug;8(2):157-68]

-- The Sirtuin1 gene, once called the "holy grail" of longevity and believed to be the gene target of calorie restriction, has not been found to be universally activated by a limited calorie diet. A calorie-restricted diet results in more Sirtuin1 gene-derived proteins by exerting stabilization effects, not by activation of the gene. This new finding throws a scientific cloud over the use of Sirtuin1 gene activation tests as a measure of resveratrol activity. [Tissue-specific regulation of SIRT1 by calorie restriction. Genes Dev. 2008 Jul 1; 22(13):1753-7; Regulation of SIRT1 protein levels by nutrient availability. FEBS Letters. 2008 Jul 9; 582(16):2417-23]

-- While researchers once advised consumers to wait for stronger synthetic molecules that can stimulate the Sirtuin1 gene by 1
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