Navigation Links
Results of Two Phase 3 CAPACITY Studies of Pirfenidone in IPF Presented at American Thoracic Society (ATS)
Date:5/19/2009

ally significant and clinically meaningful effect on both the primary endpoint of change in percent predicted FVC and secondary endpoints of progression-free survival and categorical change in percent predicted FVC. While CAPACITY 1 did not achieve statistical significance on the primary endpoint, the results were generally consistent with and supportive of CAPACITY 2. Further, the treatment effect observed in the CAPACITY studies was generally consistent with that observed in the Phase 3 study of pirfenidone in IPF patients conducted by Shionogi & Co. Ltd. in Japan."

Dr. Roland du Bois, Professor of Medicine at National Jewish Health, Denver, Colo., and CAPACITY co-chair also commented on the CAPACITY results. "When taken in the context of the urgent unmet medical need for new medicines to treat IPF patients, the collective efficacy and safety data from the two CAPACITY studies, corroborated by a similar study in Japan, make a case for the use of pirfenidone in this disease setting."

Primary Efficacy Endpoint Results

The primary endpoint of both CAPACITY studies was change in percent predicted Forced Vital Capacity (FVC) after 72 weeks of treatment, evaluated with a nonparametric rank ANCOVA. In the CAPACITY 2 study, the primary endpoint was met (p=0.001). In CAPACITY 1, the primary endpoint was not met (p=0.501). An exploratory analysis of pooled primary endpoint data from both studies using the pre-specified primary endpoint test statistic from a nonparametric rank ANCOVA resulted in a P value of 0.005.

A pre-specified repeated measures analysis of the primary endpoint was used to obtain a least squares mean estimate (LS mean) of the magnitude of the treatment effect. The LS mean change in percent predicted FVC at Week 72 was -6.5% and -9.6% in the pirfenidone and placebo groups, respectively, in CAPACITY 2, and -6.5% and -7.2%, respectively, in CAPACITY 1. This represents
'/>"/>

SOURCE InterMune, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9 10 11 12

Related medicine technology :

1. Shire Announces Study Results of the Effects of INTUNIV(TM) (Guanfacine) Extended Release on Secondary Measures in Children with ADHD and Oppositional Symptoms
2. Optimer Pharmaceuticals Presents Results From Fidaxomicin Phase 3 Study for the Treatment of Clostridium difficile Infection
3. BioVex to Report Phase I/II Clinical Trial Results for the Front Line Treatment of Head and Neck Cancer With OncoVEX GM-CSF at the 2009 American Society of Clinical Oncology Meeting
4. TYRX Presents Early Clinical Results from AIGISRX(TM) Antibacterial Envelope Retrospective Registry
5. Metabolic Solutions Development Company Announces Preliminary Results from Phase IIa Clinical Trial
6. AlphaVax Announces Promising Results in Melanoma Studies
7. Ongoing Landmark ROADMAP Study Demonstrates Significant Improvement in Blood Pressure Control at One Year, According to Blinded Results
8. BioCryst Provides Peramivir Update and Reports First Quarter 2009 Financial Results
9. Bionovo Announces First Quarter 2009 Highlights and Financial Results
10. Alexza Reports 2009 First Quarter Financial Results and Updates Clinical Pipeline Status
11. ADVENTRX Announces Results From ANX-514 Bioequivalence Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... , Sept. 30, 2014  Wrightington, Wigan ... Allscripts (NASDAQ: MDRX ) are delighted to ... as WWL,s new health information system. The system will ... completely transform the way WWL delivers healthcare in the ... a demonstrated record of on-time and on-budget system implementations ...
(Date:9/30/2014)... 30, 2014 This study provides an ... informatics solutions including nuclear imaging informatics, PET imaging ... study assesses the size of the market based ... and projects future growth based on the current ... taking place in the broader markets for imaging ...
(Date:9/30/2014)... , Sept. 30, 2014  Decision Resources Group ... in Brazil , Russia ... China (BRIC) will see robust expansion ... increasingly favored over surgical procedures. Although revenues will be ... reimbursement challenges, prolonged device approval times and demand for ...
Breaking Medicine Technology:Wrightington, Wigan and Leigh NHS Foundation Trust selects Allscripts Sunrise 2Wrightington, Wigan and Leigh NHS Foundation Trust selects Allscripts Sunrise 3Wrightington, Wigan and Leigh NHS Foundation Trust selects Allscripts Sunrise 4Analysis of the US Molecular Imaging Informatics Market 2Analysis of the US Molecular Imaging Informatics Market 3Brazilian, Russian, Indian and Chinese Markets for Peripheral Vascular Devices Will See Strong Expansion Through 2023 2Brazilian, Russian, Indian and Chinese Markets for Peripheral Vascular Devices Will See Strong Expansion Through 2023 3
... Feb. 23, 2011 Roche (SIX: RO, ROG; OTCQX: RHHBY) ... Department of Defense (DOD) to provide remote service and support ... the DOD,s secure B2B gateway. Roche is the first in-vitro ... for this remote access. The B2B gateway is ...
... Feb. 23, 2011 Xenogenics Corporation ("Xenogenics"), a majority ... MCET), is pleased to announce it has retained the ... of its capital formation strategy to help finance expanded ... In animal testing and initial human use, the ...
Cached Medicine Technology:Roche Teams with Womack Army Medical Center to Become First IVD Manufacturer approved for Remote Network Connectivity with DOD 2Xenogenics Corporation Retains the Emmes Group to Advise on Fund Raising Efforts 2Xenogenics Corporation Retains the Emmes Group to Advise on Fund Raising Efforts 3Xenogenics Corporation Retains the Emmes Group to Advise on Fund Raising Efforts 4
(Date:10/1/2014)... 2014 Woodland Hills dental ... group of dental specialists who treat full mouth implant ... of Oviedo. Dr. Reshad of the Anacapa Dental Art ... on two continents, will give a full-day presentation Oct. ... reconstruction. , “These specialists want to improve their skills ...
(Date:10/1/2014)... (PRWEB) October 01, 2014 Generic drug ... retail generics increasing in price in the last 12 ... Inc.’s (AIS) Drug Benefit News (DBN) interviewed a plan ... means for pharmacies and health plans. , “When ... rising generic acquisition costs, these cost increases squeeze pharmacies’ ...
(Date:10/1/2014)... insulin is safer and more effective than intermediate-acting ... to new research published in the BMJ ... twice-daily doses of both long- and intermediate-acting insulin, ... "In patients with Type 1 diabetes, we found ... when it came to controlling blood sugar, preventing ...
(Date:10/1/2014)... Looking for holiday gift ideas? Éminence Organic Skin ... giving easy this holiday season. Starting October 1st 2014, new ... all shopping dilemmas. Choose from two luxury skin care gift ... delicate eye area or to deliver whole body beauty. ... Duo Gift Set are formulated to suit all skin types ...
(Date:10/1/2014)... 01, 2014 To help raise awareness about ... Cutler Integrative Medicine, is detailing several tips for women looking ... According to Dr. Cutler, women should start each day with ... yourself that will help ‘center’ yourself for the rest of ... says. , Other health and fitness tips include:, -Drink ...
Breaking Medicine News(10 mins):Health News:Woodland Hills Dental Implants Expert Training Dental Specialists in Spain Later This Week 2Health News:Woodland Hills Dental Implants Expert Training Dental Specialists in Spain Later This Week 3Health News:Woodland Hills Dental Implants Expert Training Dental Specialists in Spain Later This Week 4Health News:Rising Generic Drug Prices Affect Pharmacies, Insurers Alike, Reports AIS Newsletter 2Health News:Rising Generic Drug Prices Affect Pharmacies, Insurers Alike, Reports AIS Newsletter 3Health News:Long-acting insulin is safer, more effective for patients with Type 1 diabetes 2Health News:Éminence Organic Skin Care Launches Limited Edition Spa Gift Sets for the Holiday Season 2Health News:Éminence Organic Skin Care Launches Limited Edition Spa Gift Sets for the Holiday Season 3Health News:In Recognition of National Women’s Health and Fitness Day, Cutler Integrative Medicine Details Tips for Living a Healthier and Happier Life 2
... routinely discarded placenta //might be a good source of stem ... of the journal Stem Cells. ,Researchers had found that ... of the amniotic sac have cells that are very similar ... two genes that make the embryonic stem cells unique in ...
... Researchers from Douglas Hospital Research Center in Montreal showed ... to deal with stressful situations than those who bottle-feed ... well established, this is for the first time findings ... as well. Researchers feel that this is good for ...
... 2005. Hormone Replacement Therapy (HRT) is commonly advocated in ... with increased chances of breast cancer and recently anxiety has ... Medical Journal// the cumulative risk of such a cancer developing ... as was previously reported. ,A team from New ...
... days when drinking was considered to be forbidden. It has ... ,A new research has found that drinking is not all ... reported to have better verbal skills, memory and speed of ... Moderate drinkers not only performed the best but also seemed ...
... wet hair may be far more effective treatment of ... used single blind randomized controlled trial for comparing the ... against head lice in United Kingdom. , ,Fine ... current over the counter chemical treatments for eliminating head ...
... The Food and Drug Administration FDA has recently ... prescription drug advertisements. ,The FDA and the ... practices for drugs, with agency research showing that ... benefits and do not adequately disclose risks. FDA's ...
Cached Medicine News:Health News:Researchers Gather Stem Cells From Discarded Placenta 2Health News:Breastfeeding Lowers Maternal Stress 2Health News:Risk of Breast Cancer Overestimated with Hormone Replacement Therapy(HRT) Treatment 2Health News:Yet Another Reason To Celebrate Drinking 2Health News:Combing Hair More Effective Than OTC Medicine For Head Lice 2
Portable shields for your safety and convenience....
Provide 1.5mm protection throughout. Six durable, attractive vinyl coverings are available. Lead glass window factory installed. Larger window available....
Swing-Arm™ Scatter Shield® provides lower extremity protection for personnel close to the tube. 24"Wx32"L lead shield swings 180 along table. Ideal for cardiac cath, special studies, electr...
Front Protection with attached Belt Guard, Built-in Back Support; Buckle Closure...
Medicine Products: