Navigation Links
Results from Study Evaluating PROCRIT(R) in Intensive Care Unit Patients Published in New England Journal of Medicine
Date:9/5/2007

(trauma, surgery non-trauma and medical non-trauma) were performed similarly to the overall population.

Study Findings

There was no significant difference in the percentage of patients who received a RBC transfusion at day 29 between the PROCRIT and placebo groups (46% vs. 48.3%, p=0.34; relative risk 0.95, 95% confidence interval (CI), 0.85, 1.06). In addition, there was no difference between treatment groups in the total number of RBC units transfused through study day 42.

As noted by the authors, the most likely explanation for the lack of transfusion reduction was a change in transfusion practice. In two prior trials in critically ill patients, the PROCRIT group did achieve a reduction in RBC transfusions. In these studies, the mean pre-transfusion Hb concentration was 8.5 g/dL. In contrast in this trial, the mean pre- transfusion Hb concentration observed was 8.0 g/dL and the percentage of patients transfused was lower.

Mortality at study day 29 was significantly lower in the PROCRIT group (Kaplan-Meier (K-M) estimates: 8.5% vs. 11.4%, p=0.02). The mortality benefit with PROCRIT was most apparent in the trauma subgroup (K-M estimates: 3.5% vs. 6.6%, p=0.04). The mortality pattern at day 140 was similar for the overall group (K-M estimates: 14.2% vs. 16.8%, p=0.08) and the trauma subgroup (K-M estimates: 6.0% vs. 9.2%, p=0.08). The adjusted hazard ratios confirmed the mortality findings for trauma patients at days 29 (0.37, 95% CI, 0.19, 0.72) and 140 (0.40, 95% CI, 0.23, 0.69). The increase in Hb at day 29 was greater for patients who received PROCRIT (1.6 plus or minus 2.0 g/dL for patients receiving PROCRIT vs. 1.2 plus or minus 1.8 g/dL for patients receiving placebo, p<0.001).

As expected in a population of critically ill patients, adverse events and serious adverse events were frequent. A total of 690 (94.8%) PROCRIT patients and 680 (94.4%) placebo patients experienced at least one adverse event. Similarly, 44% of PROCRIT pa
'/>"/>

SOURCE Ortho Biotech Products, L.P.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Point of Care Cardiac Analyzers Yield Rapid Cardiac Marker Results
2. Diagnosing Diabetes: Immediate HbA1c Results Improve Glycemic Control
3. Cell Therapeutics, Inc. Management to Discuss Todays Announcement of Interim Pixantrone Study Results
4. Sygnis Pharma AG announces date for presentation of clinical results
5. Phase 3 Results for Dabigatran Etexilate, an Investigational Oral Anticoagulant, Presented Today at the XXIst Congress of the International Society on Thrombosis and Haemostasis
6. Positive Aggrastat Results Featured in the Journal of the American College of Cardiology
7. Pixantrone Combination Therapy for First-line Treatment of Aggressive Non-Hodgkins Lymphoma Results in Reduction in Severe Toxicities Including Heart Damage When Compared to Doxorubicin-based Therapy
8. Halozyme Therapeutics Enhanze Technology Large Protein Molecule Therapeutic Clinical Trial Results Presented at the 34th Annual Meeting of the Controlled Release Society
9. Manhattan Pharmaceuticals Announces Results of Phase 2a Studies for Oral Oleoyl-estrone
10. Actemra (tocilizumab) Third Phase III Study Results Show Significant Improvement in Symptoms of Patients with Rheumatoid Arthritis
11. AM-Pharma Announces Positive Results of Phase IIa Clinical Trial with Alkaline Phosphatase For Ulcerative Colitis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... YORK und KISSING, Deutschland, 31. ... Hersteller und Distributor eines computerunterstützten („robotischen") Koloskopie-Systems ... Nachum (Homi) Shamir , ein weltweit anerkannter ... Leitungs- und Kontrollgremiums zum Unternehmen stößt. ... Shamir ist ein hochangesehener globaler ...
(Date:7/31/2014)... , July 31, 2014 Orexigen® Therapeutics, Inc. ... for the second quarter 2014, on Thursday, August 7, ... by a live webcast and conference call at 8:00 ... Orexigen management will host the call and webcast to ... call may be accessed by calling (800) 708-4540 (domestic) ...
(Date:7/31/2014)... July 31, 2014 Nutrastar International Inc. (OTCQB: ... supplier of premium branded consumer products, including commercially cultivated ... foods, today announced the signing of its first distributor ... expansion to Hubei Province ... Central China . The contract ...
Breaking Medicine Technology:invendo medical holt Nachum (Homi) Shamir in den Board of Directors des Unternehmens 2invendo medical holt Nachum (Homi) Shamir in den Board of Directors des Unternehmens 3Orexigen Therapeutics to Host Second Quarter 2014 Financial Results Conference Call and Webcast 2Nutrastar Signs First Distributor for New Cordyceps Powder Solution Product, Expands Reach to Central China 2Nutrastar Signs First Distributor for New Cordyceps Powder Solution Product, Expands Reach to Central China 3Nutrastar Signs First Distributor for New Cordyceps Powder Solution Product, Expands Reach to Central China 4
... 10, 2012  Nine prominent science institutions have joined Bio ... site for graduate level life science professionals.  In total, ... the top graduate programs in the life sciences. ... Louisville, Rochester, University of Texas Medical Branch, and Virginia ...
... The AquaLab Vapor Sorption Analyzer (VSA) , ... moisture in products and pinpoint quality control issues.  The ... changes can reveal important details about physical and chemical ... called an isotherm.  Isotherm generation technology ...
Cached Medicine Technology:Bio Careers Adds 9 Universities, Reaching 40 Members 2New AquaLab Vapor Sorption Analyzer Puts Isotherm Technology Within Financial Reach of Food and Pharmaceutical Scientists 2
(Date:7/31/2014)... 2014 You’re having a wonderful summer—sunning, gardening, ... suddenly developed chills and fever, headache, stiff neck, achey joints, ... flu-like illness, it could actually be the first sign of ... developing Lyme is greater than you might think. Until last ... in the U.S. annually. But the Centers for Disease Control ...
(Date:7/31/2014)... Two years in the making, Becoming Vegan: ... the research behind the latest scientific findings on the ... Melina, well-respected authorities on plant-based nutrition, put forth an ... adequate for people at all stages of life, including ... pregnant or lactating women. , Well-planned is the ...
(Date:7/31/2014)... Most mommy blogs are simple family journals, confessionals or ... all mothers from all walks of life. Magazines/websites ... high fashion or child rearing. When Felicia Blendermann became ... was so segmented. “I found myself visiting various sites ... search Google to get information on another. At the ...
(Date:7/31/2014)... 2014 (HealthDay News) -- Many black women put concerns ... research. It,s estimated by the U.S. Centers for ... black women in the United States are overweight or ... to avoid having to have their hair restyled or ... authors said. However, the researchers also noted a shift ...
(Date:7/31/2014)... study published today in Genes & Development ... Sciences Centre,s DNA Replication group, in collaboration with ... intricate mechanisms involved in the enzyme that governs ... sophisticated system using synthetic, chemical and structural biology ... involved in duplicating genetic information embraces DNA through ...
Breaking Medicine News(10 mins):Health News:Feel Like You Have A Summertime 'Flu'? It Could Be Lyme Disease 2Health News:Feel Like You Have A Summertime 'Flu'? It Could Be Lyme Disease 3Health News:New Book Presents Health Professionals With A Fully-Referenced, Meticulous Overview of the Research on Plant-Based Diets As A Healthy Choice 2Health News:New Book Presents Health Professionals With A Fully-Referenced, Meticulous Overview of the Research on Plant-Based Diets As A Healthy Choice 3Health News:Mommylish Launches Its Website 2Health News:Hairdo Trumps Exercise for Many Black Women, Study Finds 2Health News:Molecular gate that could keep cancer cells locked up 2
... close relatives proposed , , FRIDAY, Sept. 7 (HealthDay News) ... close relatives of people with coronary heart disease could ... Scottish researchers say. , "If you want primary prevention, ... groups with high risk," explained Dr. Jill Pell, professor ...
... Sept. 7 A group of golfers received,quick and ... surprising,natural remedy. Created by Earth,s Balance, Golfers Rx provided ... golfers with a week,or more of constant itching. ... the microscopic,oak leaf gall mite, also known as the ...
... G.,Rendell has proclaimed Sept. 9 - 15 as "Senior ... play in the lives of older,Pennsylvanians., "Senior community ... for older adults," said Governor Rendell. "The more than ... to stay active,and healthy, continue learning, share experiences and ...
... Inc. (NYSE: HB ) today announced its ... This dividend was declared by Hillenbrand,s,Board of Directors ... shareholders of,record as of September 14, 2007. ... organized into two operating companies,serving the health care ...
... or more alcoholic beverages a day may double their ... researchers at the University of Southern California (USC). The ... and is now available online. , This is the ... alcohol and endometrial cancer, says Veronica Wendy Setiawan, assistant ...
... Process, FRESNO, Calif., Sept. 7 Healthcare workers ... Joslin on,Thursday: the union-busting tactics going on at the ... there at risk. The workers instead urged Joslin ... who are interested in forming a union. Workers,could then ...
Cached Medicine News:Health News:Family History Has Strong Effect on Cardiac Risk 2Health News:Family History Has Strong Effect on Cardiac Risk 3Health News:Big Relief for Tiny Itch Mites Found in All Natural Spray Remedy 2Health News:Governor Rendell Proclaims Sept. 9-15 as 'Senior Community Center Week' 2Health News:Frequent alcohol consumption increases cancer risk in older women 2Health News:Hospital Workers: Management Threatens Patient Care 2
Designed to provide comfortable support, protection and immobilization MCP joint along with immobilization of the wrist...
Design allows for easy-one hand application to provide support and immobilization of the wrist while preserving finger mobility...
... Cronin, Inc. is a ... Footwear, Orthopedic Softgoods, and ... Our products are of ... available in the USA ...
Comfort Wrist Immobilizer with thumb abduction. 8"L, soft, padded comfort-type wrist immobilizer with dorsal metal stay. The thumb is held in abduction and splintered with a short metal stay....
Medicine Products: