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Results From an Expanded Cohort Phase 1 Study Published in the New England Journal of Medicine Demonstrate a Majority of Patients With ALK-Positive Advanced Non-Small Cell Lung Cancer Responded to Crizotinib (PF-02341066)
Date:10/27/2010

The information contained in this release is as of October 27, 2010. Pfizer assumes no obligation to update forward-looking statements contained in this release as the result of new information or future events or developments.

This release contains forward-looking information about a product candidate, crizotinib, including its potential benefits and the anticipated timing of its submission to the FDA, that involves substantial risks and uncertainties. Such risks and uncertainties include, among other things, the uncertainties inherent in research and development; decisions by the FDA and other regulatory authorities regarding whether and when to approve any drug applications that may be filed for  such  product candidate as well as their decisions regarding labeling and other matters that could affect its availability or commercial potential; and competitive developments.

A further description of risks and uncertainties can be found in Pfizer's Annual Report on Form 10-K for the fiscal year ended December 31, 2009 and in its reports on Form 10-Q and Form 8-K.

(1) Kwak E et al. Anaplastic Lymphoma Kinase Inhibition in Non-Small Cell Lung Cancer. The New England Journal of Medicine. October, 27, 2010.

(2) ESMO Accepted Abstract # 366PD. Clinical Activity of Crizotinib (PF-02341066), in ALK-Positive Patients with Non-Small Cell Lung Cancer (NSCLC).  Poster Discussion. Sunday, October 10: 12:30. David Ross Camidge – Presenter. 35th Congress of the European Society for Medical Oncology. Milan, Italy. October 8 – 12, 2010.  

(3) ClinicalTrials.gov. A study of oral PF-02341066, A c-MET/Hepatocyte Growth Factor Tyrosine Kinase Inhibitor, in Patients with Advanced Cancer. Available at: http://clinicaltrials.gov/ct2/show/NCT00585195?term=A8081001&rank=1.  Accessed August
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