Navigation Links
Results From an Expanded Cohort Phase 1 Study Published in the New England Journal of Medicine Demonstrate a Majority of Patients With ALK-Positive Advanced Non-Small Cell Lung Cancer Responded to Crizotinib (PF-02341066)
Date:10/27/2010

ormation on these clinical trials, please contact the Pfizer Oncology Clinical Trial Information Service at 1-877-369-9753 (US/Canada) or 1-646-277-4066 (international), via email at PfizerHPTrials@emergingmed.com or visit www.pfizercancertrials.com.

Study Results Published in the New England Journal of Medicine

In the Part 2 expansion cohort study which included 82 patients with ALK-positive advanced NSCLC, 57 percent (n=47)(95% CI 46%, 68%) of patients treated with crizotinib (PF-02341066) at a dose of 250 mg twice daily had either a complete or partial response to treatment.  An additional 33 percent (n=27) met criteria for stable disease, including five unconfirmed partial responses.  At eight weeks, the disease control rate (complete response (n=1) + partial response (n=46) + stable disease (n=24)) was 87 percent (n=71).  Three patients with stable disease were not included in the disease control rate because their evaluation for response was outside a pre-specified timeframe.(1)

At the time of the analysis, 77 percent of patients (n=63) continued to receive treatment with crizotinib (PF-02341066).  The median duration of treatment was 6.4 months, and follow-up is ongoing.  

The most commonly reported all-grade adverse events associated with crizotinib included nausea (n=44), diarrhea (n=39), vomiting (n=36), and mild visual disturbances (n=34).  Grade 3 ALT (alanine aminotransferase) and AST (aspartate aminotransferase) elevations occurred in four patients.  One patient experienced a Grade 4 elevation in ALT and one patient discontinued treatment due to Grade 3 ALT increases. Tumors in the analysis were primarily of adenocarcinoma histology, and patients tended to be young, and were never or former light smokers.  Ninety-three percent of patients (n=76)
'/>"/>

SOURCE Pfizer Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8

Related medicine technology :

1. Cephalon Announces Positive Results from a Pivotal Study of FENTORA in Opioid-tolerant Patients with Non-cancer Breakthrough Pain
2. Lexicon to Present Research Results at American Chemical Society Meeting Regarding Target of LX1031 Drug Candidate
3. Positive Kuvan(TM) Pivotal Phase 3 Trial Results Published in The Lancet
4. DOV Pharmaceutical, Inc. Announces Successful Phase Ib Results for DOV 21,947
5. Tapestry Reports Second Quarter 2007 Results
6. Phosphagenics Announces Positive Phase 1b Transdermal Insulin Clinical Trial Results
7. Emisphere Technologies, Inc. Announces 2007 Second Quarter Financial Results
8. Amicus Therapeutics Announces Second Quarter 2007 Financial Results
9. Genta Incorporated Announces Second Quarter 2007 Financial Results and Corporate Highlights
10. Vical Reports Second Quarter 2007 Financial Results, Allowance of Pandemic Influenza IND and Other Advances in Product Development Programs
11. MicroDose Announces Positive Results From the QDose Inhaled Insulin Glucose Clamp Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... , Aug. 20, 2014 Reportlinker.com ... is available in its catalogue: ... Key Trends and Opportunities to 2018 ... Synopsis The report provides in depth market ... personal accident and health insurance segment, including: ...
(Date:8/20/2014)... -- Children aren,t the only segment of our ... disease. The Centers for Disease Control and Prevention ... many adults are not following this advice. ... and the American Lung Association in partnership with ... disease, to talk with their health care provider ...
(Date:8/20/2014)... -- Research and Markets has announced ... Care and Closure Market (Types, Applications, End User ... Profiles, Demand, Insights, Analysis, Research, Report, Opportunities, Segmentation ... their offering. The new report ... (types, applications, end user and geography) - Size, ...
Breaking Medicine Technology:Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 2Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 3Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 4Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 5Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 6Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 7Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 8Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 9Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 10Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 11Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 12Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 13Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 14Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 15Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 16Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 17Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 18Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 19Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 20Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 21Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 22Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 23American Lung Association Urges Adults with Lung Disease to Consult their Health Care Provider to Stay Current on Vaccinations 2American Lung Association Urges Adults with Lung Disease to Consult their Health Care Provider to Stay Current on Vaccinations 3Global Advanced Wound Care and Closure Market (Types, Applications, End User and Geography) - Forecast to 2020 2
... Coast Dental Services, Inc., announced today that it ... of Dental Technology, Inc. (DTI), doing business as SmileCare, ... care service plan. DTI and its subsidiaries operate 57 ... 1,200 staff members, including 130 dentists.  The transaction is ...
... The Food and Drug Administration says some companies are ... falsely claim to treat, prevent, or cure STDs. Are ... big risk unless you see a healthcare provider who ... http://photos.prnewswire.com/prnh/20090824/FDALOGO ) View a video, slideshow, and ...
Cached Medicine Technology:Coast Dental to Acquire the Assets of SmileCare 2
(Date:8/20/2014)... most persistent and deadliest infectious diseases in the world, ... Scientists who study tuberculosis have long debated its origins. ... in Africa to seals and sea lions that brought ... Native people there before Europeans landed on the continent. ... a Source of New World Human Tuberculosis," was published ...
(Date:8/20/2014)... (PRWEB) August 20, 2014 As concerns ... of power morcellators ( http://www.injurybeacon.com/power-morcellator/ ) in gynecological ... two U.S. Senators from New York are urging the ... recall of the devices. In a letter dated August ... also implored the agency to seriously consider the testimony ...
(Date:8/20/2014)... stimulates stress responses in adults, researchers at Yerkes ... that the amygdala has an inhibitory effect on ... primates. , The results are published this week ... amygdala is a region of the brain known ... and learning about threats. Alterations in the amygdala ...
(Date:8/20/2014)... HealthDay Reporter TUESDAY, Aug. 19, ... a baby,s immune system is twice as common as once ... says. This is the first evaluation of the effect ... as severe combined immunodeficiency (SCID), or "Bubble Boy" disease, the ... by the boy in the bubble, who was born without ...
(Date:8/20/2014)... CA (PRWEB) August 20, 2014 The main ... 12 per diode panel band perfect spectrum that encompasses the ... most likely to use during photosynthesis. A key point ... is that they almost exclusively reside between 440-480 on the ... the red side of the spectrum. The KIND LED K3 ...
Breaking Medicine News(10 mins):Health News:New research shows seals and sea lions likely spread tuberculosis to humans 2Health News:New research shows seals and sea lions likely spread tuberculosis to humans 3Health News:Power Morcellator News: Bernstein Liebhard LLP Notes Senators’ Letter Seeking FDA Morcellator Recall 2Health News:Power Morcellator News: Bernstein Liebhard LLP Notes Senators’ Letter Seeking FDA Morcellator Recall 3Health News:Power Morcellator News: Bernstein Liebhard LLP Notes Senators’ Letter Seeking FDA Morcellator Recall 4Health News:Maturing brain flips function of amygdala in regulating stress hormones 2Health News:Maturing brain flips function of amygdala in regulating stress hormones 3Health News:'Bubble Boy' Disease May Be More Common Than Thought 2Health News:'Bubble Boy' Disease May Be More Common Than Thought 3Health News:Cheap LED Grow Lights Are Quickly Being Replaced by Premium Grow Lights 2
... , FRIDAY, July 31 (HealthDay News) -- A gene associated ... blindness, has been identified by scientists. , The EphA2 gene ... of damaged proteins in the eye. Expression of the EphA2 ... together and cause the eye lens to become cloudy, resulting ...
... , , , LAWRENCE, ... ), a leading manufacturer of innovative dialysis products, today announced that ... Canaccord Adams Global Growth Conference on Tuesday, August 11, 2009 at ... NxStage,s investor presentation is scheduled for Tuesday, August 11th at 10:00 ...
... , , WOODLAND HILLS, Calif., ... provider of advertising and marketing opportunities for national brands in health ... (NYHRC) chain has agreed to join its network. , ... HCMN will immediately begin installation of its static and digital panel ...
... , CHENNAI, India, July 31 ... Children,s Hospital, the,First Standalone Quaternary Care Paediatric Hospital in the ... ) , The Apollo Children,s ... adolescents up to the age of 16 years all,under one ...
... ... section featuring the latest news and trends from the "wellness" world. , ... Seattle, WA (PRWEB) July 31, ... and sleep-deprived society, alternative medicine and natural health have become a great alternative to ...
... ... to disseminating information on dentistry,s role in the recognition and management of snoring and sleep ... the second month in a row. , ... New York, NY (PRWEB) July 31, 2009 -- Snoring Isn,t Sexy, LLC, a ...
Cached Medicine News:Health News:NxStage to Present at the Canaccord Adams Global Growth Conference 2Health News:Health Club Media Network Adds New York Health & Racquet Club 2Health News:Oscar Award Winner, Dr. A.R. Rahman inaugurates Apollo Children's Hospital - the First Standalone Quaternary Care Paediatric Hospital in the Apollo Hospitals Group 2Health News:Natural Healers Launches "Wellness Community Bulletin" 2Health News:Natural Healers Launches "Wellness Community Bulletin" 3Health News:Natural Healers Launches "Wellness Community Bulletin" 4Health News:SnoringIsntSexy.com Tops 21,000 Site Visits for Second Month in a Row 2
Female Mini-VEST, Front Closure, X-Firm...
For Lipoplasty or surgery of abdomen, flanks and midriff...
Female High Waist Briefs...
Short-Sleeve Bolero for targeted compression in the upper arms, back and shoulder areas. Plush-shielded hook and eye front closure for comfort and convenient application....
Medicine Products: