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Results From Two Phase II Trials Add to Understanding of Ticagrelor (BRILINTA(TM)) and How it Works in the Body
Date:11/18/2009

ORLANDO, Fla., Nov. 18 /PRNewswire-FirstCall/ --AstraZeneca (NYSE: AZN) today announced the results of the phase II studies, ONSET/OFFSET and RESPOND for ticagrelor (BRILINTA(TM)) at the annual American Heart Association (AHA) Scientific Sessions in Orlando, FL,(1,2) with ONSET/OFFSET study results being simultaneously published in the medical journal Circulation.(3)

The ONSET/OFFSET data showed that treatment with ticagrelor (BRILINTA(TM)) achieved a more rapid onset of antiplatelet effect (41% IPA vs. 8% at 30 minutes; P<0.0001), greater inhibition of platelet aggregation (IPA) that was sustained during maintenance phase of treatment (IPA; P<0.0001 at all times) and faster offset IPA compared to clopidogrel, in patients with stable coronary artery disease (CAD) on aspirin therapy.

Platelets initiate the formation of blood clots by sticking together (clumping or aggregating), a process called platelet aggregation. Inhibition of platelet aggregation (IPA) is the prevention of clumping of platelets in the blood, which reduces the risk of clot formation and subsequent thrombotic events.

These results were achieved using ticagrelor 180 mg loading dose followed by 90 mg twice daily, as studied in PLATO (A Study of Platelet Inhibition and Patient Outcomes), compared to clopidogrel 600 mg loading dose followed by 75 mg once daily dose.(1)

Key findings:(1)

  • Greater IPA occurred with ticagrelor compared to clopidogrel at time points of 0.5, 1, 2, 4, 8 and 24 hours after patients received initial treatment dose and at 6 weeks (P<0.0001 for all)
  • At 2 hours after patients received initial treatment dose a greater proportion of patients achieved >50% IPA (98% vs. 31%, P<0.0001) and >70% IPA (90% vs. 16%, P<0.0001) in the ticagrelor versus clop
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SOURCE AstraZeneca
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