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Researchers at Scripps to Study Possible New Treatment for Parkinson's Disease
Date:1/25/2013

eir own DNA, just in a different form. Our hope is that this will slow or stop the progression of Parkinson's disease while minimizing the potential for rejection."

Pluripotent stem cells

Stem cells are unspecialized cells that can regenerate and can be directed to convert into specific tissue or organ cells with specialized functions.

"The word 'pluripotent' means that the cells can turn into any other kind of cell," said Dr. Loring. "We're converting adult cells taken from skin samples into pluripotent stem cells. These simple skin cells are now in the middle of a remarkable journey toward becoming nerve cells, and we're excited to explore their use as a viable treatment for Parkinson's disease."

Preliminary research will likely be completed in 2013. That stage will be followed by preparation of the cells for clinical use when the group plans to join other qualified organizations to help design a national, multicenter trial. The clinical trial is slated to launch two or three years later, depending on the timeframe required for obtaining FDA and other regulatory approvals.

Parkinson's disease symptoms and treatment

Healthy nerve cells in our brains produce molecules called neurotransmitters, including dopamine, which is a chemical that helps control muscle movement. In Parkinson's disease, nerve cells degenerate, and the resulting loss of dopamine leads to symptoms that include muscle tremor, muscle stiffness, trouble walking, imbalance and speech problems.

While Parkinson's disease itself is technically not fatal, the Centers for Disease Control and Prevention rated complications from the disease as the 14th leading cause of death in the United States; it is estimated to affect one in 100 people over age 60. While medications and surgery can be helpful in lessening symptoms, there is not currently a cure for Parkinson's disease.

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