Navigation Links
Researchers Use Nanoparticles as Destructive Beacons to Zap Tumors
Date:7/21/2010

PHILADELPHIA, July 21 /PRNewswire-USNewswire/ -- A group of researchers from Wake Forest University Baptist Medical Center is developing a way to treat cancer by using lasers to light up tiny nanoparticles and destroy tumors with the ensuing heat.

Today at the 52nd Annual Meeting of the American Association of Physicists in Medicine (AAPM) in Philadelphia, they will describe the latest development for this technology: iron-containing Multi-Walled Carbon Nanotubes (MWCNTs) -- threads of hollow carbon that are 10 thousand times thinner than a human hair.

In laboratory experiments, the team showed that by using an MRI scanner, they could image these particles in living tissue, watch as they approached a tumor, zap them with a laser, and destroy the tumor in the process.

If this sounds like science fiction, it is not. The work builds on an experimental technique for treating cancer called laser-induced thermal therapy (LITT), which uses energy from lasers to heat and destroy tumors. LITT works by virtue of the fact that certain nanoparticles like MWCNTs can absorb the energy of a laser and then convert it into heat. If the nanoparticles are zapped while within a tumor, they will boil off the energy as heat and kill the cancerous cells.

The problem with LITT, however, is that while a tumor may be clearly visible in a medical scan, the particles are not. They cannot be tracked once injected, which could put a patient in danger if the nanoparticles were zapped away from the tumor because the aberrant heating could destroy healthy tissue.

Now the team from Wake Forest Baptist has shown for the first time that it is possible to make the particles visible in the MRI scanner to allow imaging and heating at the same time. By loading the MWCNT particles with iron, they become visible in an MRI scanner. Using tissue containing mouse tumors, they showed that these iron-containing MWCNT particles could destroy the tumors when hit with a laser.

"To find the exact location of the nanoparticle in the human body is very important to the treatment," says Xuanfeng Ding, M.S., who is presenting the work today in Philadelphia. "It is really exciting to watch the tumor labeled with the nanotubes begin to shrink after the treatment."

The results are part of Ding's ongoing Ph.D. thesis work -- a multi-disciplinary project led by Suzy Torti, Ph.D., professor of biochemistry at Wake Forest Baptist, and David Carroll, Ph.D., director of the Wake Forest University Center for Nanotechnology and Molecular Materials, that also includes the WFB Departments of Physics, Radiation Oncology, Cancer Biology, and Biochemistry.

A previous study by the same group showed that laser-induced thermal therapy using a closely-related nanoparticle actually increased the long-term survival of mice with tumors. The next step in this project is to see if the iron-loaded nanoparticles can do the same thing.

If the work proves successful, it may one day help people with cancer, though the technology would have to prove safe and effective in clinical trials.

Dan Bourland, Ph.D., associate professor of radiation oncology and Ding's advisor, praises the high quality of Ding's work and says that the project is a strong example of today's "team science" that is needed for success in the biomedical fields.

The presentation "MR Relaxation Properties for Fe-Containing MWCNTs and Potential for Combined MR Imaging and Tumor Ablation Therapy" by X Ding et al. will be at 4:00 p.m. on Wednesday, July 21 in room 204B of the Philadelphia Convention Center.

ABSTRACT: http://www.aapm.org/meetings/amos2/pdf/49-13471-21772-60.pdf

ABOUT AAPM

The AAPM is a scientific, educational, and professional nonprofit organization whose mission is to advance the science, education and professional practice of medical physics. The Association encourages innovative research and development, helps disseminate scientific and technical information, fosters the education and professional development of medical physicists, and promotes the highest quality medical services for patients. Please visit the Association Web site at http://www.aapm.org/

For more information, please contact:

Jason Socrates Bardi,

American Institute of Physics,

301-209-3091 (office)

858-775-4080 (cell)

jbardi@aip.org


'/>"/>
SOURCE American Association of Physicists in Medicine
Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. Elsevier Appoints Top Diabetes and Endocrinology Researchers as Editors
2. Karmanos Cancer Institute Researchers Study Bisphosphonates and Their Affect on Early Stage Breast Cancer
3. Drexel Biomedical Researchers Develop Device to Predict Diabetic Wound Healing
4. Researchers at MD Anderson Show That Positron Emission Mammography (PEM) Helps Evaluate Early Response to Neoadjuvant Chemotherapy
5. SRI International Researchers Present Promising New Therapeutic for the Treatment of Multiple Myeloma
6. Researchers Pave Way for Tracking of Prostate Motion With a Single kV Imager During Arc Radiotherapy
7. IPA Helps Researchers Utilize and Share Current Disease Knowledge Through New Dynamic Reporting Capability
8. Researchers Announce Medical Breakthrough with Simple, Inexpensive Blood Test for Colon Cancer
9. AVAC Says MDP 301 Microbicide Trial Results Disappointing, but Researchers and 9,400 Trial Volunteers Deserve Praise for Successful Trial
10. Neuro Kinetics & Military Researchers in Push To Improve Diagnosis & Treatment of Combat Brain Injuries
11. Sigma-Aldrich Announces SAGE(TM) Priority Partners Program; Seeks Researchers to Evaluate New Knockout Rat Models
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2017)... March 27, 2017  PhaseRx, Inc. (NASDAQ: PZRX), ... inherited liver diseases in children, today reported financial ... ended December 31, 2016 and provided an update ... continued to make progress during the fourth quarter ... from our non-human primate safety study, and with our ...
(Date:3/24/2017)... Research and Markets has announced the ... report to their offering. ... The Cell Therapy Manufacturing Market, 2017-2027 report ... cell therapy manufacturing and focuses both on contract manufacturers and ... anticipated to emerge as viable alternatives to conventional treatment options. ...
(Date:3/24/2017)... , March 24, 2017  Zymo ... company, and Hamilton Robotics, Inc., who designs, ... an ongoing collaboration that teams Zymo Research,s ... RNA and DNA extraction products with Hamilton,s ... created optimized methods for microbiomics and RNA ...
Breaking Medicine Technology:
(Date:3/27/2017)... ... 27, 2017 , ... The Association of Healthcare and Value ... their first Northeast Regional AHVAP Meeting. For 2017, Dr. Hayes will provide the ... value analysis professionals have a ‘seat at the table’ with clinical committees when ...
(Date:3/27/2017)... ... March 27, 2017 , ... Sodium determination is consistently becoming ... require expert user knowledge. In a live webinar on April 11th and October ... highly accurate, determination of sodium. , It has long been known that too ...
(Date:3/27/2017)... Fla. (PRWEB) , ... March 27, 2017 , ... ... overdose deaths soared 167%,(1) with opioids alone responsible for over 33,000 of the ... McCarty has sponsored Assembly Bill (AB) 1512, which proposes a tax on prescription ...
(Date:3/25/2017)... ... ... Getting earned media coverage meaningful for Garden Media Group's clients is the ... Garden Media aims to provide material helpful to clients’ goals and bottom lines. By ... messages to gain coveted media placements, Garden Media wows clients year-round. , Here ...
(Date:3/24/2017)... ... March 24, 2017 , ... ... will spark a conversation on the current obstacles facing infection prevention and offer ... preventable deaths caused by these infections. , The print component of “Fighting ...
Breaking Medicine News(10 mins):