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Researchers Use Magnetism to Target Cells to Animal Arteries
Date:1/7/2008

ies, using endothelial cells to deliver beneficial genes to damaged arteries.

The delivery system, says Levy, might also be applied to other sites where physicians implant steel stents to deliver medication, such as the esophagus, bile ducts and lungs. Another potential use might be in orthopedic procedures, in which surgeons implant steel nails to stabilize fractured bones, or use steel screws to correct spinal abnormalities. In such cases, magnetized nanoparticles might deliver bone stem cells to strengthen bony structures.

"Magnetic fields produced by ordinary MRI machines could suffice to deliver cells to targets where they could promote healing, since MRI uses uniform fields, which are key to our targeting strategy," added Levy. "This method could become a powerful medical tool."

Financial support for the study came from the National Institutes of Health, the Nanotechnology Institute, and both the William J. Rashkind Endowment and Erin's Fund of The Children's Hospital of Philadelphia. Dr. Levy's co-authors were Ilia Fishbein, M.D., Michael Chorny, Ph.D., Ivan S. Alferiev, Ph.D., and Darryl Williams, of Children's Hospital; Boris Polyak, M.D., and Gary Friedman, Ph.D., of Drexel University; and Ben Yellen, Ph.D., of Duke University.

About The Children's Hospital of Philadelphia: The Children's Hospital of Philadelphia was founded in 1855 as the nation's first pediatric hospital. Through its long-standing commitment to providing exceptional patient care, training new generations of pediatric healthcare professionals and pioneering major research initiatives, Children's Hospital has fostered many discoveries that have benefited children worldwide. Its pediatric research program is among the largest in the country, ranking third in National Institutes of Health funding. In addition, its unique family-centered care and public service programs have brought the 430-bed hospital recognition as a leading advocate for children and ado
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SOURCE The Children's Hospital of Philadelphia
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