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Researchers Train the Immune System to Deliver Virus That Destroys Cancer in Lab Models
Date:12/18/2007

s removed T-cells from a healthy mouse, loaded them with the virus and injected the T-cells back into the mouse. Researchers found that once the T-cells returned to the lymph nodes and spleen, the virus detached itself from the T-cells, found the tumor cells, selectively replicated within them and extracted tumor cells from those areas.

CANCER VACCINE

The procedure used in this study triggered an immune response to cancer cells, which means that it could be used as a cancer vaccine to prevent recurrence.

"We show that if you kill tumor cells directly in the tumor itself, you can get a weak immunity against the tumor, but if you use this virus to kill tumor cells in the lymph nodes, you get a higher immunity against the tumor," Dr. Vile says.

RESULTS

The technique used in this study successfully treated the cells of three different diseases: melanoma, lung cancer and colorectal cancer. The results include:

-- Two days after treatment, the presence of melanoma tumor cells in lymph nodes was significantly less, but not completely gone. There were no cancer cells in the spleen.

-- Ten-to-14 days after a T-cell transfer, both the lymph nodes and spleen were free of melanoma tumor cells.

-- Mice treated with a single dose of the T-cells transfer developed a potent T-cell response against melanoma tumor cells.

-- Although the procedure was not intended to treat the primary melanoma tumor, significant reductions in tumor cells were observed.

-- In mice with lung cancer metastasis, cancer cells were significantly reduced in one-third of mice and completely eradicated in two-thirds of mice. Efforts to clear metastases from colorectal tumors were similarly effective.

-- Lung and colorectal tumor cells were purged from lymph nodes. Also, the spleens of mice that had lung cancer developed immunity to the cancer after the treatment.

The technology already exists to extract
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SOURCE Mayo Clinic
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