Navigation Links
Researchers Show That Combining Intensity Modulated Radiation Therapy With Chemo-Radiation Offers Long-Term Benefits And Reduced Side Effects For Oropharyngeal Cancer Patients
Date:8/13/2015

PALO ALTO, Calif., Aug. 13, 2015 /PRNewswire/ -- Combining intensity-modulated radiotherapy (IMRT) with chemotherapy to treat locally advanced oropharyngeal (head and neck) cancer improves long-term health-related quality of life (HRQOL) outcomes by sparing the swallowing and salivary organs, according to a study by researchers at the University of Michigan.1

IMRT is advanced therapy that closely conforms the radiation dose to the size, shape and location of the tumor to minimize complications in surrounding healthy tissues. The researchers compared outcomes between combining chemotherapy with IMRT versus combining chemotherapy with conventional radiotherapy techniques. "Our study shows that patients with locally advanced head and neck cancer treated with chemo-radiation using swallowing and salivary-organ sparing IMRT techniques experienced stable or improved health-related quality of life outcomes 6 years later," said Avraham Eisbruch, MD, Department of Radiation Oncology, University of Michigan. "This contrasts significantly with prior reports about HRQOL outcomes after chemo-radiation using conventional radiation therapy techniques. The long-term benefits and reduced side effects for IMRT patients included less dry mouth, fewer swallowing difficulties, and greater freedom from dependence on feeding tubes."

In September 2013, Eisbruch, along with lead study authors Jeffrey Vainshtein, MD, Dominic Moon, MD, and several other colleagues enrolled 40 patients in a long-term health-related quality of life study, which required them to complete questionnaires regarding long-term outcomes and side effects. All of the patients had been treated for stage III/IV oropharyngeal cancer between May 2003 and January 2011 using chemo-IMRT swallowing and salivary-organ sparing techniques. The median follow-up after chemoradiation treatment was 6.5 years. At the time of this study, all patients were free of head and neck cancer.

While chemo-radiation therapy (CRT) has long been considered the standard-of-care for patients with locally advanced head and neck cancer, CRT using traditional radiotherapy techniques often caused severe side effects, such as dry mouth and swallowing difficulties, resulting in feeding tube dependence and other complications that reduced the quality of life. Conversely, patients in this study who were treated with swallowing and salivary organ-sparing chemo-IMRT reported, more than 6 years after treatment, that they were experiencing stable or improved health-related quality of life outcomes, with the majority of patients experiencing freedom from feeding tubes (97.5%), dry mouth, and swallowing problems (95%).

"Although this study was small in size, it contains some of the first really long-term data we have to show that, by using swallowing- and salivary structure-sparing chemo-IMRT to treat locally advanced head and neck cancer, we can significantly impact our patients' post-treatment quality of life," Eisbruch said. "Future advances in swallowing and salivary organ-sparing chemo-IMRT techniques may enable us to improve health-related quality of life outcomes even more."

1Vainshtein, JM, et al. Long-term quality of life after swallowing and salivary-sparing chemo-intensity modulated radiation therapy in survivors of human papillomavirus-related oropharyngeal cancer. International Journal of Radiation Oncology • Biology • Physics. 2015; 91 (5): 925–933.

About Varian Medical Systems
Varian Medical Systems, Inc. (NYSE: VAR), of Palo Alto, California, focuses energy on saving lives by equipping the world with advanced technology for fighting cancer and for X-ray imaging. The company is the world's leading manufacturer of medical devices and software for treating cancer and other medical conditions with radiation. The company provides comprehensive solutions for radiotherapy, radiosurgery, proton therapy and brachytherapy. The company supplies informatics software for managing comprehensive cancer clinics, radiotherapy centers and medical oncology practices. Varian is also a premier supplier of X-ray imaging components, including tubes, digital detectors, and image processing software and workstations for use in medical, scientific, and industrial settings, as well as for security and non-destructive testing. Varian Medical Systems employs approximately 6,900 people who are located at manufacturing sites in North America, Europe, and China and approximately 70 sales and support offices around the world. For more information, visit http://www.varian.com or follow us on Twitter.

FOR INFORMATION CONTACT:

Meryl Ginsberg, 650-424-6444
meryl.ginsberg@varian.com

 


'/>"/>
SOURCE Varian Medical Systems
Copyright©2015 PR Newswire.
All rights reserved

Related medicine technology :

1. Sony Biotechnology Inc.s New Technology for Science Provides Researchers Results in Color
2. University Researchers Use Biozoom Scanner To Investigate Relationship Between Stress And Work
3. BiOptix announces low cost Surface Plasmon Resonance Services for Colorado-based researchers
4. Tisch MS Researchers Announce Breakthrough in Disease Monitoring
5. Northwestern Medicine Researchers Investigate New Stent Technology to Treat Coronary Artery Disease
6. Pharmaceutical Giants Back Researchers in Unique US Competition
7. Kaiser Permanente Researchers Honored for Drug Therapy Study
8. Transparency Life Sciences Partners With Oncology Researchers At Icahn School Of Medicine At Mount Sinai To Assess Metformin In Prostate Cancer
9. Nova Southeastern University Researchers Receive $4.1 Million Grant from Department of Defense to Investigate Gulf War Illness
10. Researchers Use CT and 3-D Printers to Recreate Dinosaur Fossils
11. ideaPoint, Inc. Announces Launch of Multi-Sponsor Portal Providing Researchers Opportunity to Request Access to Clinical Data from Five Global Study Sponsors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/10/2020)... ... 2020 , ... By mid-January, many people’s New Year’s resolutions have fallen by the wayside. ... Night Wellness Retreat for the 2020 season. , Open each year from the last spring ... in May and the first weekend of October. The new dates for New Life Hiking ...
(Date:1/8/2020)... ... January 08, 2020 , ... E.M.M.A. International Consulting Group, Inc. ... the attainment of a national certification as a Women’s Business Enterprise by the ... Enterprise National Council (WBENC). , "We are so pleased to receive the National ...
(Date:1/8/2020)... PHOENIX (PRWEB) , ... January 09, 2020 , ... ... is now offering its partner practices a complimentary freezer program. The cryogenic freezer ... for procedures. , The top stem cell and exosome biologics require cryogenic freezing. ...
Breaking Medicine Technology:
(Date:1/23/2020)... ... January 23, 2020 , ... ... with memory impairment, has announced the Best Memory Care Facilities in Pensacola, Florida. ... facility features and amenities. , According to the Alzheimer’s Association , ...
(Date:1/23/2020)... ... 2020 , ... Dr. Dan Myers and The Dentist Centers Sandy Springs are ... professional dental staff. The Dentist Centers is a state-of-the-art family practice, offering ... and restorative dentistry, all in a relaxing, comfortable environment. , As a new addition ...
(Date:1/23/2020)... WASHINGTON (PRWEB) , ... January 23, 2020 , ... ... 2020 IRF Executive Committee and the IRF Board of Trustees. Representing all segments ... the foundation in meeting its mission of conducting research and providing education highlighting ...
(Date:1/22/2020)... ... January 22, 2020 , ... ... appointed Ilana Glazer as its new external relations director. In her role, ... relations, grants administration, external communications, community education, brand strategy, public policy, and ...
(Date:1/12/2020)... ... January 11, 2020 , ... The co-founder and CEO ... coinciding with the annual JP Morgan Healthcare Conference. On Sunday, January 12, Sujuan ... medical technology company investors and advisers at the San Francisco office of international ...
Breaking Medicine News(10 mins):