Navigation Links
Researchers Set Record for Detecting Smallest Virus, Opening New Possibilities for Early Disease Detection
Date:8/28/2012

NEW YORK, Aug. 28, 2012 /PRNewswire/ -- Researchers at Polytechnic Institute of New York University (NYU-Poly) have created an ultra-sensitive biosensor capable of identifying the smallest single virus particles in solution, an advance that may revolutionize early disease detection in a point-of-care setting and shrink test result wait times from weeks to minutes. 

(Logo: http://photos.prnewswire.com/prnh/20091027/NY99197LOGO )

Stephen Arnold, university professor of applied physics and member of the Othmer-Jacobs Department of Chemical and Biomolecular Engineering, and researchers of NYU-Poly's MicroParticle PhotoPhysics Laboratory for BioPhotonics (MP3L) reported their findings in the most recent issue of Applied Physics Letters, published by the American Institute of Physics.

Their technique is a major advance in a series of experiments to devise a diagnostic method sensitive enough to detect and size a single virus particle in a doctor's office or field clinic, without the need for special assay preparations or conditions. Normally, such assessment requires the virus to be measured in the vacuum environment of an electron microscope, which adds time, complexity and considerable cost.

Instead, the researchers were able to detect the smallest RNA virus particle MS2, with a mass of only 6 attograms, by amplifying the sensitivity of a biosensor. Within it, light from a tunable laser is guided down a fiber optic cable, where its intensity is measured by a detector on the far end. A small glass sphere is brought into contact with the fiber, diverting the light's path and causing it to orbit within the sphere. This change is recorded as a resonant dip in the transmission through the fiber. When a viral particle makes contact with the sphere, it changes the sphere's properties, resulting in a detectable shift in resonance frequency.

The smaller the particle, the harder it is to record these changes. Viruses such as influenza are fairly large and have been successfully detected with similar sensors in the past. But many viruses such as Polio are far smaller, as are antibody proteins, and these require increased sensitivity. 

Arnold and his co-researchers achieved this by attaching gold nano-receptors to the resonant microsphere. These receptors are plasmonic, and thus enhance the electric field nearby, making even small disturbances easier to detect.  Each gold "hot spot" is treated with specific molecules to which proteins or viruses are attracted and bind.

Arnold explained that the inspiration for this breakthrough technique came to him during a concert by violinist Itzhak Perlman: "I was watching Perlman play, and suddenly I wondered what would happen if a particle of dust landed on one of the strings. The frequency would change slightly, but the shift would be imperceptible. Then I wondered what if something sticky was on the string that would only respond to certain kinds of dust?"

In experiments, the researchers successfully detected the smallest RNA virus in solution, and they are now training their sights on detecting single proteins, which would represent a major step toward early disease detection.

"When the body encounters a foreign agent, it responds by producing massive quantities of antibody proteins, which outnumber the virus. If we can identify and detect these single proteins, we can diagnose the presence of a virus far earlier, speeding treatment," Arnold said. "This also opens up a new realm of possibilities in proteomics," he said, referring to the study of proteins. "All cancers generate markers, and if we have a test that can detect a single marker at the protein level, it doesn't get more sensitive than that." 

This patent-pending technology, co authored with postdoctoral fellow Siyka Shopova and graduate student Raaj Rajmangal, is ultimately designed for a point-of-care device capable of detecting viruses or disease markers in blood, saliva or urine. Testing for commercial applications is already under way.

The sensor itself, called a Whispering Gallery-Mode Biosensor, is unique to Arnold's work. Its name derives from the famous Whispering Gallery in the dome of St. Paul's Cathedral in London. Much the way its unique acoustics allow a whisper to be heard anywhere within the circular gallery, light traveling within the glass sphere of the biosensor orbits many times, ensuring nothing on the surface is missed.

The technique was pioneered by NYU-Poly MP3L post-doctoral researchers, graduate and undergraduate students, along with Stephen Holler, NYU-Poly alum and now an assistant professor of physics at Fordham University. A technology entrepreneur, Holler founded NovaWave Technologies, a chemical sensor company, at one of NYU-Poly's business incubators. Thermo Fisher Scientific, one of the world's leading providers of scientific and laboratory equipment, acquired NovaWave in 2010. Other authors of the paper are Venkata Dantham, NYU-Poly postdoctoral fellow; Vasily Kolchenko, now professor at New York City College of Technology's Department of Biological Sciences; and Zhenmao Wan, currently a graduate student in the Department of Physics at Hunter College of CUNY.

This research was originally supported by provost seed funds from the New York University (NYU) School of Arts and Sciences, in a grant jointly awarded to Arnold and NYU Professor of Physics David Grier. The National Science Foundation provided additional funding.

About Polytechnic Institute of New York University

Polytechnic Institute of New York University (formerly Polytechnic University), an affiliated institute of New York University, is a comprehensive school of engineering, applied sciences, technology and research, and is rooted in a 158-year tradition of invention, innovation and entrepreneurship: i2e. The institution, founded in 1854, is the nation's second-oldest private engineering school. In addition to its main campus in New York City at MetroTech Center in downtown Brooklyn, it also offers programs at sites throughout the region, around the globe and remotely through NYUe-Poly. NYU-Poly is an integral part of NYU Abu Dhabi, NYU Shanghai and the NYU Center for Urban Science and Progress (CUSP) in downtown Brooklyn. For more information, visit www.poly.edu.


'/>"/>
SOURCE Polytechnic Institute of New York University
Copyright©2012 PR Newswire.
All rights reserved

Related medicine technology :

1. Rethinking Research Ethics: Carnegie Mellon and McGill Researchers Challenge Post-marketing Trial Practices
2. Van Andel Institute Researchers Find Potential Drug Target For Aggressive Form Of Lymphoma
3. Researchers Evaluate Computer-based Treatment for People with Schizophrenia
4. Aethlon Medical (AEMD) Note: Cancer Treatment Publication Authored by Aethlon Medical Researchers Now Available
5. Researchers Developing New Multiple Sclerosis Drug That Can Be Taken Orally
6. Researchers Discover All-Natural Weapon In The War Against Ovarian Cancer
7. Latest Breakthroughs and Treatments in Spinal Cord Injury Medicine Bring Top Clinicians and Researchers Together in Las Vegas
8. Young Innovations, Inc. Announces Record Sales and EPS for the Quarter Ended March 31, 2012
9. Kelyniam Global Inc. Reports Record Cranial Implant Revenues in the 1st Quarter of 2012
10. CryoLife Reports Record Quarterly Revenues in First Quarter of 2012
11. CVS Caremark Reports Record First Quarter Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/20/2017)... CHICAGO , June 19, 2017  Hill-Rom Holdings, Inc. ... conference call and webcast on Friday, July 28, 2017, beginning ... Conference Call Audio Only Dial-in information: To participate in the ... Please dial into the call at least 10 minutes prior ... Code is 34090339.  ...
(Date:6/14/2017)... -- ivWatch LLC, a medical device company focused on improving ... pleased to announce it was the Bronze Winner last ... Equipment at the 2017 Medical Design Excellence Awards (MDEAs), ... award was presented by Medical Device and Diagnostics Industry ... New York during MD&M East, the ...
(Date:6/12/2017)... 12, 2017 Kineta, Inc., a biotechnology company focused ... Vice President of R&D and Head of Virology Kristin ... Preparedness for the Northwest and Beyond meeting sponsored by ... 14, 2017 from 8:30-10:30 AM PDT at the Agora Conference ... Dr. Bedard will be joined by other leaders in ...
Breaking Medicine Technology:
(Date:6/22/2017)... ... , ... Groove Ring is excited to announce they've partnered with Olympic runner ... and all-purpose rings. Whether you’re an athlete, adventurer, professional, or love to venture the ... From the rock face to the auto shop, Groove Ring is the world's first ...
(Date:6/22/2017)... , ... June 22, 2017 , ... ... announced today that it has received certification for ANSI/ASIS PSC.1-2012. The company’s work ... in environments where the rule of law has been degraded. The PSC.1 standard ...
(Date:6/20/2017)... ... June 20, 2017 , ... Connance, ... health system, will present how predictive analytics drive reimbursement optimization, with a focus ... Orlando, June 25-28. , “The traditional approach to denied and underpaid claims ...
(Date:6/20/2017)... ... June 20, 2017 , ... ... has published a new eBook titled “ 5 Questions to Ask Before Entering ... Analyst on the Genetic Test Evaluation (GTE) team, the book explores the various ...
(Date:6/20/2017)... ... , ... HOUSTON – Brazos Towers at Bayou Manor is proud to ... for today’s modern senior. Brazos Towers at Bayou Manor has more than 50 years ... them the services to support that lifestyle both now and in the future. Instead ...
Breaking Medicine News(10 mins):