Navigation Links
Researchers Developing New Multiple Sclerosis Drug That Can Be Taken Orally
Date:7/10/2012

MENLO PARK, Calif., July 10, 2012 /PRNewswire/ -- The Department of Defense (DoD) has awarded SRI International a one-year grant to develop a novel therapy for multiple sclerosis (MS), an autoimmune nervous system disease that affects about 400,000 people in the United States and more than two million people worldwide. There is currently no cure for this disorder, which can impair vision and movement.

The grant, funded through DoD's Congressionally Directed Medical Research Programs, will support the development of an oral drug that targets miR-326, a molecule recently found to stimulate the production of immune system mediators known as T-helper 17 (Th17) cells. Patients with MS have high levels of miR-326, and Th17 is thought to play a critical role in causing MS and other autoimmune diseases. The new therapy will inhibit miR-326 and block the production of Th17 cells.

The novel, orally administered drug will be more convenient for patients than currently available treatments. MS treatments today often require frequent hospital visits for injections or intravenous infusions. The new drug could also help patients who do not respond to existing medications, or who experience significant side effects as a result of taking them.

"New and more convenient and effective therapeutics for multiple sclerosis are greatly needed," said Jennifer Lam, Ph.D., a research scientist in SRI's Biosciences Division who is spearheading the project. "Our research is directed toward the development of a novel oral therapeutic as well as a deeper understanding of the mechanisms that contribute to MS."

The project described was supported by Award Numbers W81XWH-11-1-0736 from the U.S. Army Medical Research Acquisition Activity. The content of the information does not necessarily reflect the position or the policy of the Government, and no official endorsement should be inferred

About SRI's Biosciences Division
SRI's Biosciences Division carries out basic research, drug discovery, and drug development, and provides contract services. SRI has all of the resources necessary to take R&D from Idea to IND®—from initial discovery to the start of human clinical trials—and specializes in cancer, immunology and inflammation, infectious disease, and neuroscience. SRI's product pipeline has yielded marketed drugs, therapeutics currently in clinical trials, and additional programs in earlier stages. In its CRO business, SRI has helped government and other clients and partners advance well over 100 drugs into patient testing. SRI is also working to create the next generation of technologies in areas such as diagnostics, drug delivery, medical devices, and systems biology.

About SRI International
Innovations from SRI International have created new industries, billions of dollars of marketplace value, and lasting benefits to society—touching our lives every day. SRI, a nonprofit research and development institute based in Silicon Valley, brings its innovations to the marketplace through technology licensing, new products, and spin-off ventures. Government and business clients come to SRI for pioneering R&D and solutions in computing and communications, chemistry and materials, education, energy, health and pharmaceuticals, national defense, robotics, sensing, and more.


'/>"/>
SOURCE SRI International
Copyright©2012 PR Newswire.
All rights reserved

Related medicine technology :

1. Aethlon Medical (AEMD) Note: Cancer Treatment Publication Authored by Aethlon Medical Researchers Now Available
2. Researchers Evaluate Computer-based Treatment for People with Schizophrenia
3. Van Andel Institute Researchers Find Potential Drug Target For Aggressive Form Of Lymphoma
4. Rethinking Research Ethics: Carnegie Mellon and McGill Researchers Challenge Post-marketing Trial Practices
5. Sirnaomics Received NIH SBIR Grant for Developing Its Scarless Wound Healing siRNA Therapeutics
6. Wound Management Products Market Reaches $15.2 Billion by 2016, Driven by Rising Demand for Bandages and Dressings in Developing World
7. Frost & Sullivan: Developing Integration Capabilities Presents a Real Opportunity for Vendors in the European CIS Market
8. Hearing Loss Could Lead to Multiple Chronic Diseases for Millions of Brits
9. Multiple Sclerosis Association of Americas MRI Institute Marks 10 Years of Helping Individuals with Multiple Sclerosis Obtain MRIs
10. Aushon to Launch New Multiplex Immunoassay Platform
11. Roskamp Institute Reports Beneficial Effects of Nutritional Supplementation with Anatabine in an Animal Model of Multiple Sclerosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/5/2016)... SANTA MONICA, Calif. , Dec. 5, 2016 /PRNewswire/ ... PINK: PRLX), is pleased to announce that its pharmaceutical ... serve Medicare B clients, allowing coverage in all of ... business in. Michael Rashti Pharm ... "This is a very exciting for our business. Medicare ...
(Date:12/5/2016)... Dec. 5, 2016  Pennsylvania Physician General Dr. ... Programs Gary Tennis today filled prescriptions for ... Pharmacy in York to demonstrate ... Dr. Levine as a prescription to acquire naloxone at ... important to remember that any Pennsylvanian can walk up ...
(Date:12/5/2016)... BOCA RATON, Fla. , Dec. ... the Commercialization of Public Research (the Florida ... funding agreement SegAna, LLC, an Orlando ... of Central Florida. The Florida Institute supports new ... early funding gaps for companies spinning out of Florida-based ...
Breaking Medicine Technology:
(Date:12/5/2016)... ... December 05, 2016 , ... Progressive Laboratories™ is one ... glutathione to enhance production of nitric oxide (NO). , NitroGenesis Pro™ is made ... NO twice as effectively and sustains NO blood levels twice as long as ...
(Date:12/5/2016)... ... December 05, 2016 , ... Eating disorders are equal ... Castlewood Treatment Centers has always been to promote the power of recovery, and ... possible. In that spirit, Castlewood has announced two new hires, both Outreach Directors ...
(Date:12/5/2016)... ... December 05, 2016 , ... U.S. Apple Association (USApple) begins the ... the second annual Apples for Education: Buy an Apple, Help a Student ... food for students to take home to their families; solar technology to efficiently process ...
(Date:12/5/2016)... GREENWICH, CT and MALVERN, PA (PRWEB) , ... ... ... Clinical Supplies Management ("CSM"), a Great Point Partners ("GPP") portfolio company, ... Clinical Research – Clinical Supplies ("TCS"). TCS was previously a subsidiary ...
(Date:12/5/2016)... ... 05, 2016 , ... The legislation – S2718A/A2116A ... a licensed physical therapist, to render care for certain patients. In most cases, ... a licensed physical therapist (PT) and throughout the treatment cycle is supported by ...
Breaking Medicine News(10 mins):