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Researchers Create First Targeted Knockout Rats Using Zinc Finger Nuclease Technology
Date:7/23/2009

d understanding of B-cell development and a novel approach to the inactivation of endogenous antibody expression. The antibody platform is available for all targets, has broad freedom to operate, and uses technology protected by patents. For more information about OMT, contact Roland Buelow at rbuelow@omtinc.net or visithttp://www.omtinc.net.

About INSERM UMR 643: The INSERM UMR 643 is a French public academic laboratory. Its scientific activity is centered in the analysis of immune responses and in immunointervention strategies in organ transplantation. The rat is an important immunological model, and INSERM routinely generates transgenic rats using DNA or lentiviral vector microinjection. The generation of transgenic rats also is open to the scientific community through an open facility. More information is available at www.ifr26.nantes.inserm.fr/ITERT/transgenese-rat.

Cautionary Statement: This release contains forward-looking statements relating to future performance, goals, strategic actions and initiatives and similar intentions and beliefs and other statements regarding Sigma-Aldrich's and Sangamo's expectations, goals, beliefs, intentions and the like, which involve assumptions regarding the Companies' operations and conditions in the markets the Companies serve. Actual results may differ materially from these forward-looking statements due to a number of factors. See the Companies' SEC filings, and in particular, the risk factors described in their Annual Reports on Form 10-K and their most recent report on Form 10-Q. The Companies do not undertake any obligation to update these forward-looking statements.


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