Navigation Links
Research Team Clones Genes Responsible for Amino Acid Absorption

MORGANTOWN, W.Va., May 23 /PRNewswire-USNewswire/ -- Researchers at the West Virginia University School of Medicine have discovered ways to block substances that interfere with absorption of nutrients in patients with inflammatory bowel disease (IBD), according to Uma Sundaram, M.D., Section Chief of Digestive Diseases at WVU.

"The most important step before development of drugs that could replace steroids in treating this chronic condition is to find out the specific bodily immune substance that causes the problem. This is the focus of our research," Dr. Sundaram said. "Our lab has shown for the first time not only how an important building block of proteins, glutamine, is absorbed, but also we have cloned a gene responsible for this absorption. And most important, we have shown how the absorption of this important nutrient is affected in IBD."

Details of these discoveries are included in one of nine presentations by Sundaram's research team at the Digestive Disease Week (DDW) conference in San Diego, Calif. The DDW conference began May 17 and continued through May 22. It's described as the world's largest gathering of its type involving physicians and researchers.

The most common chronic disease affecting the human small intestine, IBD affects more than a million people in this country and many more millions around the world.

"In the majority of cases of inflammatory bowel disease, patients are unable to properly assimilate chemicals, water and nutrients that are critical for daily life," Sundaram said.

Sundaram described the WVU lab's breakthroughs as akin to looking for a needle in a haystack in identifying which mediators interfere with what substance the body needs to absorb.

"We have found the needle for a few of the big ones such as how fat, glucose, salt and glutamine absorption is affected," he said. "The next step would be to find specific treatments for inflammatory bowel disease that avoid all the complications of steroids and other drugs currently available."

Sundaram said these discoveries may have equally important implications for conditions such as obesity, which is a serious health concern in West Virginia.

The digestive disease research is funded with National Institutes of Health grants totaling almost $5 million over five years. Five of the research team's papers were published earlier this year in the American Journal of Physiology.

For more information on the WVU Healthcare and digestive diseases, visit

This news release was issued on behalf of Newswise(TM). For more information, visit

SOURCE West Virginia University School of Medicine
Copyright©2008 PR Newswire.
All rights reserved

Related medicine technology :

1. The Multiple Myeloma Research Consortium (MMRC) and Proteolix Initiate Phase 2 Clinical Trial Investigating Carfilzomib for the Treatment of Multiple Myeloma
2. Multiple Myeloma Research Consortium (MMRC) Partners with Novartis to Advance Phase II Study of Deacetylase Inhibitor
3. Lexicon to Present Research Results at American Chemical Society Meeting Regarding Target of LX1031 Drug Candidate
4. Researchers at Cleveland Clinic Identify Site of Dysfunction in HDL, Carrier of Good Cholesterol
5. Video: New Research Discovers Independent Brain Networks Control Human Walking
6. Quark Pharmaceuticals Extends Research Agreement with State University of New York for Proprietary siRNA Compounds for Acute Hearing Loss
7. Cleveland Clinic Researchers Identify Mechanism Behind Platelet Function and Potentially Fatal Blood Clot Formation
8. HistoRx and Radiation Therapy Oncology Group Initiate Brain Tumor Biomarker Research Partnership
9. Diabetes Research Institute Invention Promotes Growth of Stem Cells into Insulin-Producing Cells
10. Researchers Identify Virus Possibly Responsible for Declining Honeybee Population Using 454 Sequencing Technology from Roche
11. Peregrine Researchers Report Data Showing Bavituximabs Potential to Shrink Human Prostate Tumors in Model of Relapsed Disease
Post Your Comments:
(Date:11/26/2015)... , November 26, 2015 /PRNewswire/ ... announced the addition of the  "2016 ... the Global Cell Surface Testing Market: ... report to their offering.  --> ... addition of the  "2016 Future Horizons ...
(Date:11/26/2015)... , November 26, 2015 /PRNewswire/ ... --> adds "Global ... and "Investigation Report on China Repaglinide ... 2021 forecasts data and information to ... . --> ...
(Date:11/25/2015)... DUBLIN , Nov. 25, 2015 /PRNewswire/ ... announced the addition of the "Global ... to their offering. --> ... "Global Brain Monitoring Devices Market 2015-2019" ... Research and Markets ( ) ...
Breaking Medicine Technology:
(Date:11/27/2015)... , ... November 27, 2015 , ... MPWH, the No.1 Herpes-only dating community in the ... Table 1-1 ). More than 3.7 billion people under the age of 50 ... (HSV-1), according to WHO's first global estimates of HSV-1 infection . , "The data ...
(Date:11/27/2015)... ... November 27, 2015 , ... A simply groundbreaking television series, "Voices ... show that delves into an array of issues that are presently affecting Americans. Dedicated ... open dialogue, this show is changing the subjects consumers focus on, one episode at ...
(Date:11/27/2015)... Los Angeles, CA (PRWEB) , ... November 27, 2015 , ... ... the Commission on Accreditation of Allied Health Education Programs (CAAHEP) awarded accreditation to its ... exclusive list of CAAHEP accredited colleges, as only one of twelve colleges and universities ...
(Date:11/27/2015)... ... November 27, 2015 , ... Avid collector, Andrew Hawley from Vintage ... style concert posters. This is one of Joplin's most famous and beautiful concert posters. ... University of Michigan in Ann Arbor. The According to Hawley, "It is hard to ...
(Date:11/26/2015)... (PRWEB) , ... November 26, 2015 , ... Inevitably when ... Many customers choose to buy during the Black Friday and Cyber Monday ... don’t need to search the Internet high and low to find the best massage ...
Breaking Medicine News(10 mins):