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Research Suggests FORTEO® Significantly Increases Bone Strength
Date:9/19/2011

afety information, including Boxed Warning regarding osteosarcoma, below.

About the Study6

"Increases in both vertebral and femoral strength in postmenopausal osteoporotic women after 18 months of treatment with teriparatide" was an 18-month, open-label study using finite element analysis of quantitative CT scans to analyze the effects of treatment with FORTEO on vertebral and proximal femoral strength.

Quantitative CT scans were taken of the lumbar spine and hip at baseline and at 18 months (or at an early termination visit). All patients who had two evaluable CT scans at both time points were included in the analysis (n=30 spine; n=26 hip).

Volumetric density was measured for the trabecular, peripheral (outer 2-3 mm of bone that contains both cortical and some adjacent trabecular bone) and both ("integral") compartments. Non-linear finite element analysis was performed for uniform compression for the spine and a sideways fall for the hip to provide measures of vertebral and femoral strength.

Important Safety Information about FORTEO

What is the most important information I should know about FORTEO?

WARNING: POTENTIAL RISK OF OSTEOSARCOMA

During the drug testing process, the medicine in FORTEO caused some rats to develop a bone cancer called osteosarcoma. In people, osteosarcoma is a serious but rare cancer. Osteosarcoma has been reported rarely in people who took FORTEO. It is not known if people who take FORTEO have a higher chance of getting osteosarcoma. Before you take FORTEO, you should tell your healthcare provider if you have Paget's disease of bone, are a child or young adult whose bones are still growing, or have had radiation therapy.



Who should not take FORTEO?

  • You should not take FORTEO for mor
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SOURCE Eli Lilly and Company
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