Navigation Links
Research Presented at ISHLT Shows Promise of Addressing Critical Organ Shortage and Better Organ Preservation
Date:4/10/2008

BOSTON, April 10 /PRNewswire/ -- Data from experimental work on the use of organs from cardiac arrested donors will be presented this week at the International Society for Heart and Lung Transplantation's 28th Annual Meeting and Scientific Sessions. Utilizing donors after cardiac death (DCD), also known as non-heart-beating donors (NHBDs) has the potential to overcome a critical shortage of suitable donor organs for lung, and possibly heart, transplantation.

In addition, strategies for organ preservation during transport from donor to recipient will be a primary topic of discussion at the ISHLT meeting running through Saturday at the Boston Marriott Copley Place and Hynes Convention Center.

"There is a worldwide shortage of quality donor organs for transplantation. This year, we are going to hear about clinical updates on non-heart-beating lung donors, and also exciting new experimental work on the possible use of hearts from cardiac-arrested donors," said Steven Tsui, M.D., F.R.C.S., Director of Transplantation and Surgeon, Papworth Hospital, U.K. "In addition, there has been a lot of interest in techniques aiming to maintain, and possibly improve, donor organ function once they have been removed from the donor."

NON-HEART-BEATING DONORS

Organ transplantation is currently limited by a shortage of suitable donors, which results in longer waiting times for patients and a substantial risk of dying before transplantation.

Promising research results suggest the potential to immediately increase the number of lungs available for transplantation. Although thousands of patients are on lung transplant waiting lists around the world, only a small percentage actually receive transplants. And likewise, a small proportion of individuals identified as organ donors actually have suitable lungs for transplantation.

During the ISHLT mini-oral session I: The Non-Heart Beating Donor for Heart Transplantation, Ayyaz Ali, F.R.C.S., Transplant Fellow from Papworth, will provide a report regarding the potential for resuscitating donor hearts from NHBDs using extracorporeal perfusion, which in turn could mean a larger portion of donor hearts being used to transplant patients who need them (Abstract #143).

RE-CONDITIONING DONOR ORGANS

Donor organs tend to deteriorate with time after brain-stem death. They may suffer further injury during transport to the recipient hospital. From time-to-time, their function declines so much that they can no longer be transplanted safely. It may be possible to maintain donor organs in a more healthy state during transport or even improve their function to make transplantation safer.

"Recently introduced concepts such as various Ex-Vivo Lung Perfusion (EVLP) techniques will be discussed during the Meeting. Likewise, clinical experience of the innovative Organ Care System (OCS) for donor hearts will be reported," said Dr. Tsui.

The cold preservation method, which has been in practice for more than 25 years, delivers the organ in a non-functioning state immersed in a cold solution for preservation during transport. The time during transport in this method is referred to as cold ischemic time, more specifically the interval beginning when an organ is removed from the donor and is cooled with the solution, to the time when the organ is implanted.

Conversely, the Organ Care System (OCS) is based on warm blood perfusion technology, which it uses to maintain organs in a warm, functioning state. With OCS, the warm state mimics the environment of the human body during transport from organ donor to recipient. Nutrient rich, oxygenated blood is continuously pumped through the heart in order to maintain the organ in a living, beating state. Preserving an organ with this method reduces cold ischemic time and allows for evaluation of organ function during transport.

About ISHLT

The International Society for Heart and Lung Transplantation (ISHLT) is a not-for-profit organization dedicated to the advancement of the science and treatment of end-stage heart and lung diseases. Created in 1981, the Society now includes more than 3,000 members from 45-plus countries, representing a variety of disciplines involved in the management and treatment of end-stage heart and lung disease.

ISHLT maintains two vital databases. The International Heart and Lung Transplant Registry is a one-of-a-kind registry that has been collecting data since 1983 from 223 hospitals from 18 countries. The ISHLT Mechanical Circulatory Device (MCSD) database has been collecting data since 2002 with the aim of identifying patient populations who may benefit from MCSD implantation; generating predictive models for outcomes; and assessing the mechanical and biological reliability of current and future devices. In Fall 2006, ISHLT released the first international guidelines for heart failure patient management. For more information, visit http://www.ishlt.org.

Contact: Lauren Mason (210) 857-2521

lmason@masonpr.com


'/>"/>
SOURCE International Society for Heart and Lung Transplantation
Copyright©2008 PR Newswire.
All rights reserved

Related medicine technology :

1. RSV Researcher Makes Gains in Finding Treatments
2. New Research for Mechanical Support Devices in Pediatrics to Be Released at International Heart and Lung Transplant Meeting
3. Sunesis Pharmaceuticals to Present Non-Clinical Data at the Annual Meeting of the American Association for Cancer Research
4. SpineMark Partners With Regional Spine Leaders to Launch Its First Multisite Spine Research Organizations in Los Angeles, Denver
5. Alseres Pharmaceuticals, Inc. to Address a Congressional Briefing on Paralysis Research and the Spinal Cord Injury Community at Working 2 Walk in Washington, DC, April 13-15, 2008
6. Navigenics(TM) Genome Analysis Used In Research Trial on the Impact of Providing Genetic Risk Assessments
7. Recent siRNA Research Publications Support Silence Therapeutics Combined Development Approach
8. ACORNs Oncology-focused Contract Research Organization Exceeds Projections
9. Low Acid Coffee Backed By Scientific Research
10. Early Research Suggests Umbilical Cord Blood Cell Therapy May Reduce Progression of Alzheimers Disease
11. Stem Cell Research Provides Medical Breakthrough to Repair Heart Cell Damage Created by a Heart Attack
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/6/2016)...  Nearly 30 million people in the ... diabetes. 1 However, nearly 40% of diabetes patients ... and significant glucose variability. 2 These patients are at ... If left untreated, hyperglycemia can lead to cardiovascular disease, ... 3 As part of Diabetes Awareness ...
(Date:12/6/2016)... , Dec. 6, 2016  Arcturus Therapeutics, Inc. ... company, announced today that it entered into collaboration ... therapeutics for the treatment of NASH and other ... delivery platform LUNAR™ and UNA Oligomer chemistry. The ... Takeda,s long-standing commitment to and expertise in GI ...
(Date:12/6/2016)... Delaware , December 6, 2016 Breast Pump ... per a new research report by Global Market Insights, Inc. ... ... logo , ... Increasing global population, growing women employment rates and rising consumer awareness regarding ...
Breaking Medicine Technology:
(Date:12/7/2016)... ... December 07, 2016 , ... Maureen ... Program at Reproductive Medicine Associates of Connecticut (RMACT). McLaughlin brings nearly 20 years ... three acupuncturists to help patients realize their family building goals. Acupuncture helps ...
(Date:12/7/2016)... ... (PRWEB) December 07, 2016 , ... Angioma ... by cerebral cavernous angiomas, was awarded a grant from the Julian Grace Foundation ... New Mexico has more people with cavernous angioma than anywhere in the world. ...
(Date:12/6/2016)... (PRWEB) , ... December 06, 2016 , ... ... their brain networks that can be seen on a type of MRI, according ... is a progressive disorder of the central nervous system characterized by tremors or ...
(Date:12/6/2016)... ... , ... An inventor, from Talladega, Ala., thought there needed to be a ... SLING-VEST. , The SLING-VEST provides an effective way to support and align the arm ... a result, it helps to reduce discomfort and shifting. The invention features an effective ...
(Date:12/6/2016)... ... 2016 , ... In anticipation for the New Year, Dr. Mayoor Patel has ... courses in 2017, dentists of all levels can continue to advance the services offered ... attend a variety of continuing education courses each month on topics ranging from sleep ...
Breaking Medicine News(10 mins):