Navigation Links
Research From Roswell Park and Kaiser Permanente Supports Vitamin D Supplementation for Breast Cancer Patients

The joint Roswell Park Comprehensive Cancer Center/Kaiser Permanente Northern California team behind a new study to be highlighted at the American Society of Clinical Oncology (ASCO) 2021 virtual annual meeting has found that sufficient vitamin D levels at the time of diagnosis are associated with improved outcomes among people with breast cancer.

The new research, presented by first author Song Yao, PhD, is based on Kaiser Permanente Northern California’s Pathways Study — a large prospective study in breast cancer patients that has been underway since 2006 under the direction of Larry Kushi, ScD, who is Senior Author on the new study. Dr. Yao highlighted the team’s findings in a poster discussion session today. The presentation is Clinically sufficient vitamin D levels at breast cancer diagnosis and survival outcomes in a prospective cohort of 3,995 patients after a median follow-up of 10 years (abstract 10510).

“Consistent with results from randomized trials and meta-analyses, our findings from this large, observational cohort of breast cancer survivors with long follow-up provide the strongest evidence to date for maintaining sufficient vitamin D levels in breast cancer patients, particularly among Black women and patients with more advanced stage disease,” notes Dr. Yao, a molecular epidemiologist and Professor of Oncology with the Department of Cancer Prevention and Control at Roswell Park.

 “These findings highlight not just the role of vitamin D in breast cancer prognosis, but also the contribution of and need for prospective studies in cancer survivors to complement clinical trials," says study Senior Author Lawrence Kushi, ScD, Director of Scientific Policy at the Kaiser Permanente Northern California Division of Research. 

The research team measured vitamin D levels from 3,995 women with breast cancer who were enrolled in the Pathways Study, using blood serum samples collected at the time of diagnosis. They examined potential determinants of vitamin D levels, including polygenic score. Vitamin D supplement intake, BMI, and race/ethnicity were the most influential factors on serum vitamin D levels, while genetic variants had only a limited impact, notes Dr. Yao.

The study categorized vitamin D levels based on clinical cutoffs: deficient, insufficient, or sufficient. Dr. Yao and colleagues then evaluated these levels in relation to overall survival (OS), breast cancer-specific survival (BCSS), recurrence-free survival (RFS), and invasive disease-free survival (IDFS) after a median follow-up time of 9.6 years. The researchers built Cox proportional hazards models adjusting for non-clinical, clinical and treatment factors that were further stratified by stage, estrogen receptor (ER) status and body mass index (BMI).

“Having clinically sufficient vitamin D levels at the time of breast cancer diagnosis is associated with better outcomes,” Dr. Yao notes. “While these results are consistent with our earlier analysis based on a subset of the study population, it’s significant that we saw the same trends in this much larger, longer-term data set — suggesting an ongoing benefit for patients who maintain sufficient levels through and beyond breast cancer treatment.”

The team also observed that associations were similar by ER status, and found that the association between vitamin D levels and breast cancer outcomes appeared to be stronger among study participants diagnosed at more advanced stages or with lower body mass index. Black women had the lowest vitamin D levels, which might contribute to their generally poorer outcomes after breast cancer diagnosis.

“In the context of supportive data from recent randomized trials and meta-analyses, our findings support the use of daily vitamin D supplementation to maintain sufficient vitamin D levels after breast cancer diagnosis, particularly among Black women and patients diagnosed with later-stage disease,” says senior author Christine Ambrosone, PhD, Co-Principal Investigator of the Pathways Study and Senior Vice President of Population Sciences and Chair of Cancer Prevention and Control at Roswell Park.


This press release can also be found on the Roswell Park website:

Roswell Park Comprehensive Cancer Center is a community united by the drive to eliminate cancer’s grip on humanity by unlocking its secrets through personalized approaches and unleashing the healing power of hope. Founded by Dr. Roswell Park in 1898, it is the only National Cancer Institute-designated comprehensive cancer center in Upstate New York. Learn more at, or contact us at 1-800-ROSWELL (1-800-767-9355) or

Read the full story at

Source: PRWeb
Copyright©2021 Vocus, Inc.
All rights reserved

Related medicine technology :

1. Slone Partners Places Susan Landis as Executive Director at the Association of Clinical Research Professionals’ Board of Trustees
2. Highly Accomplished Nonprofit Leader Michael Pearlmutter Named Executive Director of Cerebral Palsy Alliance Research Foundation
3. Biopreparedness Expert Gustavo Palacios, PhD, to Join Mount Sinai, Strengthening Research Collaborations with Department of Defense
4. Dove Medical Press Appoints Dr. Edgar Alfonso Romero-Sandoval Deputy Editor-in-Chief of the Journal of Pain Research
5. From Innovation to Application, Cutting-Edge Birth Defects Research to Be Recognized by the Society for Birth Defects Research and Prevention
6. New Research Looks at Impact of Service Dogs on Medication Regimens for Veterans with PTSD
7. PDA’s Glenn Wright Named Chairman of Product Quality Research Institute Board of Directors
8. University of Louisville receives $8.6 million for COVID-19 wastewater research
9. Meridian Clinical Research Opens Family Practice Site in Lincoln, NE
10. Medicine is not Immune to Racism: A Call for Us to Act According to Research at the Society of Behavioral Medicine's 42nd Annual Meeting & Scientific Sessions
11. Many HR Professionals Feel Their Departments Are Not Prepared to Thrive Post-COVID - According to New Study by the HR Research Institute
Post Your Comments:
(Date:3/30/2021)... ... March 29, 2021 , ... The University of Texas Health Science Center ... San Antonio Multispecialty and Research Hospital, a destination center for research and treatment of ... In a nod to the COVID-19 pandemic, the ceremony was held virtually. , William ...
(Date:3/30/2021)... ... March 29, 2021 , ... Iora Health ... primary care, has partnered with Devoted Health , one of the fastest-growing ... across Maricopa County and provides seniors with the highest-quality care and experience possible, ...
(Date:3/30/2021)... CITY (PRWEB) , ... March 29, 2021 , ... ... has joined the Vaccine Credential Initiative (VCI), a group bringing together leading health ... record of vaccination status, based on open, interoperable standards. By joining the VCI ...
Breaking Medicine Technology:
(Date:3/30/2021)... , ... March 29, 2021 , ... ... the 21st Century , A Virtual Workshop Presented by WCG FDAnews and Cerulean ... 4:30 pm EDT, , Are one’s SOPs written for the ...
(Date:3/30/2021)... ... March 29, 2021 , ... According to data released ... reproductive age (13-44) in need of publicly funded contraception live in counties impacted by ... Colorado’s 64 counties have lost some of their Title X resources. , The ...
(Date:3/30/2021)... ... March 29, 2021 , ... Health Literacy Innovations (HLI), a ... confusion due to low health literacy today announces a new partnership with the ... work with ACAP’s member Safety Net Health Plans, those that provide comprehensive health ...
(Date:3/30/2021)... ... ... Dr. Colin Campbell is proud to announce the 1 year anniversary in their new state ... internal medicine and is a primary care specialist who has been practicing for 23 years. ... keep South Jersey healthy one patient at a time. , “Over the past year, Dr. ...
(Date:3/30/2021)... ... March 30, 2021 , ... The COVID-19 ... and survivors; their families; and their caregivers. Crossroads4Hope is addressing the needs of ... emotional support system, MyGo2Support, which meets needs of people impacted by cancer, no ...
Breaking Medicine News(10 mins):