Navigation Links
Research Explains How Advanced Prostate Cancer Becomes Resistant to Androgen-Deprivation Therapy
Date:6/2/2008

distant sites throughout the body, such as bone, lymph nodes and internal organs.

"So far we've targeted systemic, or circulating, androgens in men with advanced prostate cancer," Mostaghel said. "What these findings suggest is that we really need to target the metastatic prostate-tumor tissue itself as the source of tumor androgens."

In addition to measuring androgen levels in distant tumor sites, the researchers analyzed gene-expression patterns in the metastatic tissue to confirm the presence of genetic pathways that control testosterone production. The researchers indeed found within the metastatic tissue the genetic transcripts necessary for making the proteins that produce testosterone and other androgen hormones.

"We not only found that metastatic-tumor tissues have high enough androgen levels within them to support continued growth of the tumor cells, but also a critically important reason behind why those androgens are there -- the discovery that the gene pathways for synthesizing androgens from cholesterol appear to be present in the distant tumor sites. This finding will allow us to start honing in on the specific source of those androgens and how we can eliminate them," Mostaghel said. "As we develop new drug targets, we will need to focus on enzymes that seem to be active in the tumor tissue itself. This offers a new way of looking at hormone suppression. In addition to systemic suppression, it suggests we also need to target hormone suppression much more specifically, inside the tumor itself." Doing so could improve treatment for patients with all stages of prostate cancer, she said, from men with metastatic disease to men with high-risk, localized tumors in which there is concern that small amounts of cancer may have escaped the prostate.

Mostaghel and colleagues feel the most promising drug targets will be inhibitors of CYP17 enzymes, which disrupt the conversion of progesterone to testosterone precursors, as well as inhi
'/>"/>

SOURCE Fred Hutchinson Cancer Research Center
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. The Multiple Myeloma Research Consortium (MMRC) and Proteolix Initiate Phase 2 Clinical Trial Investigating Carfilzomib for the Treatment of Multiple Myeloma
2. Multiple Myeloma Research Consortium (MMRC) Partners with Novartis to Advance Phase II Study of Deacetylase Inhibitor
3. Lexicon to Present Research Results at American Chemical Society Meeting Regarding Target of LX1031 Drug Candidate
4. Researchers at Cleveland Clinic Identify Site of Dysfunction in HDL, Carrier of Good Cholesterol
5. Video: New Research Discovers Independent Brain Networks Control Human Walking
6. Quark Pharmaceuticals Extends Research Agreement with State University of New York for Proprietary siRNA Compounds for Acute Hearing Loss
7. Cleveland Clinic Researchers Identify Mechanism Behind Platelet Function and Potentially Fatal Blood Clot Formation
8. HistoRx and Radiation Therapy Oncology Group Initiate Brain Tumor Biomarker Research Partnership
9. Diabetes Research Institute Invention Promotes Growth of Stem Cells into Insulin-Producing Cells
10. Researchers Identify Virus Possibly Responsible for Declining Honeybee Population Using 454 Sequencing Technology from Roche
11. Peregrine Researchers Report Data Showing Bavituximabs Potential to Shrink Human Prostate Tumors in Model of Relapsed Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2015)... MYERS, Fla. , Jan. 23, 2015  Today the ... of Novartis, Bexsero® for the prevention of serogroup ... 25. Bexsero and Pfizer,s vaccine Trumenba®, which received FDA ... helping prevent this devastating disease. "I ...
(Date:1/23/2015)... Iowa , Jan. 23, 2015  The Partnership to Fight Chronic ... health care leaders and a new study analyzing the ... The PFCD is a nationwide coalition working to educate policy makers ... released at the Capitol was focused on how the ...
(Date:1/23/2015)... 23, 2015 More than a third of reproductive-aged women ... with private insurance, filled a prescription for an opioid pain ... this week,s Morbidity and Mortality Weekly Report (MMWR). ... treat moderate to severe pain.  They are also found in ...
Breaking Medicine Technology:The National Meningitis Association (NMA) Applauds FDA Approval of Second Vaccine To Protect Against Serogroup B Meningococcal Disease 2New research shows Iowa health exchange would benefit from improvements 2New research shows Iowa health exchange would benefit from improvements 3Opioid painkillers widely prescribed among reproductive age women 2Opioid painkillers widely prescribed among reproductive age women 3
... Feb. 17 The United States, fifth hand ... home to Massena, New York this week after ... of Kleinert Kutz and University of Louisville ... UofL hand surgeons performed the Hondusky,s hand transplant ...
... Sanofi Pasteur, the,vaccines division of sanofi-aventis Group (EURONEXT ... is sponsoring a phase II clinical study of a ... causes of,hospital-acquired infection in Europe and North America. , ... the United Kingdom is investigating the,safety and efficacy of ...
Cached Medicine Technology:Fifth U.S. Hand Transplant Patient Heads Home to NY 2Fifth U.S. Hand Transplant Patient Heads Home to NY 3Sanofi Pasteur Starts a Phase II Study of a Vaccine Against Clostridium Difficile 2Sanofi Pasteur Starts a Phase II Study of a Vaccine Against Clostridium Difficile 3Sanofi Pasteur Starts a Phase II Study of a Vaccine Against Clostridium Difficile 4Sanofi Pasteur Starts a Phase II Study of a Vaccine Against Clostridium Difficile 5
(Date:1/22/2015)... January 22, 2015 Padre Murphy's and Owner ... of Pro Player Health Alliance (PPHA). The PPHA's ... in getting everyone, including NFL greats, treated for obstructive sleep ... leading groups supporting the cause in the valley. The most ...
(Date:1/22/2015)... TX (PRWEB) January 22, 2015 The Incredible ... Bodybuilder Ben Pakulski to increase lean muscle by up to ... has caught the attention of HealthyandFitZone.com’s Stan Stevenson, prompting an ... that it is a step-by-step, scientific diet formula that allows ...
(Date:1/22/2015)... 22, 2015 Blue Cross and Blue Shield ... exemplify what it means to “Live Fearless.” , ... to share their stories about how they or someone they ... others by living in the moment. By telling these types ...
(Date:1/22/2015)... York, New York (PRWEB) January 22, 2015 ... http://www.vaginalmeshlawsuit2015.com/ ) in the U.S. District Court, Southern District of ... C.R. Bard, Inc. in that proceeding’s first bellwether trial. In ... request for a new trial after finding that C.R. Bard ...
(Date:1/22/2015)... 22, 2015 A new white paper ... and person-centeredness in the long-term care environment as well ... the continuum. The paper, “The Power of Person-Centeredness in ... and practices of the patient, resident and family experience ...
Breaking Medicine News(10 mins):Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 2Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 3Health News:The Incredible Bulk: Review Examining Ben Pakulski’s Brand New Bulking Muscle Building Diet Program Released 2Health News:Blue Cross and Blue Shield of Minnesota to Showcase “Faces of Fearless” 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 3Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 4Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 3
... ... everyone will carry their snacks while on the go. KUBBE is the first and ... hassle free. , ... 17, 2010 -- KUBBE is a trendy plastic utility buckle that allows people to carry ...
... , , ... ... ... ...
... ... ... ... ...
... in the March issue of Radiology , researchers from ... have determined that an imaging exam of the heart using ... much as 91 percent less radiation than standard helical CT ... in recent years, due to its diagnostic accuracy in assessing ...
... ... ... ... ...
... ... ... ... , ...
Cached Medicine News:Health News:Pew Report: New Jersey Failing to Address Children's Dental Health Crisis 2Health News:Pew Report: New Jersey Failing to Address Children's Dental Health Crisis 3Health News:Pew Report: New Jersey Failing to Address Children's Dental Health Crisis 4Health News:Pew Report: New Jersey Failing to Address Children's Dental Health Crisis 5Health News:Pew Report: New Jersey Failing to Address Children's Dental Health Crisis 6Health News:Pew Report: New Jersey Failing to Address Children's Dental Health Crisis 7Health News:Pew Report: Connecticut is a National Leader in Addressing Children's Dental Health 2Health News:Pew Report: Connecticut is a National Leader in Addressing Children's Dental Health 3Health News:Pew Report: Connecticut is a National Leader in Addressing Children's Dental Health 4Health News:Pew Report: Connecticut is a National Leader in Addressing Children's Dental Health 5Health News:Pew Report: Connecticut is a National Leader in Addressing Children's Dental Health 6Health News:Pew Report: Connecticut is a National Leader in Addressing Children's Dental Health 7Health News:New cardiac CT technology drastically reduces patient radiation exposure 2Health News:E-Cigarette Maker Green Smoke Tells FDA to Back Off! 2Health News:E-Cigarette Maker Green Smoke Tells FDA to Back Off! 3Health News:E-Cigarette Maker Green Smoke Tells FDA to Back Off! 4Health News:Healthcare Realty Trust Announces Fourth Quarter Results 2Health News:Healthcare Realty Trust Announces Fourth Quarter Results 3Health News:Healthcare Realty Trust Announces Fourth Quarter Results 4Health News:Healthcare Realty Trust Announces Fourth Quarter Results 5Health News:Healthcare Realty Trust Announces Fourth Quarter Results 6Health News:Healthcare Realty Trust Announces Fourth Quarter Results 7Health News:Healthcare Realty Trust Announces Fourth Quarter Results 8Health News:Healthcare Realty Trust Announces Fourth Quarter Results 9Health News:Healthcare Realty Trust Announces Fourth Quarter Results 10Health News:Healthcare Realty Trust Announces Fourth Quarter Results 11Health News:Healthcare Realty Trust Announces Fourth Quarter Results 12Health News:Healthcare Realty Trust Announces Fourth Quarter Results 13Health News:Healthcare Realty Trust Announces Fourth Quarter Results 14Health News:Healthcare Realty Trust Announces Fourth Quarter Results 15
... catheter design was created to be ... still providing high suctioning efficiency. Our ... or 10 Fr) feature depth markings ... Our complete catheter line is available ...
Suction catheter with thumb valve, two eyes, whistle tip...
Tracheal Suction Latex Rubber Catheters - Thumb Control Valve...
Rubber bronchial coude catheter, X-ray opaque, one eye, whistle tip....
Medicine Products: