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Research Evaluating Effectiveness of Behavioral Counseling and Varenicline for Smoking Cessation Featured in the American Journal of Preventive Medicine
Date:5/18/2010

world" examinations of varenicline use since the original phase III studies sponsored by the manufacturer. The researchers tracked more than 1,200 Group Health adult patients who received behavioral therapy and varenicline to quit smoking. All participants received 12 weeks of varenicline, printed guides, a 5-10 minute orientation call, and access to a toll-free phone number for support as needed.

"Our findings provide important data regarding the real-world use of varenicline and show that a supportive treatment philosophy along with individualized information matter most for long-term smoking cessation success," said Gary Swan, Ph.D., director of the Center for Health Sciences at SRI International and lead author of the study. "Any of the programs show promise as a counseling tool when used in combination with varenicline."

Varenicline is a non-nicotine prescription medicine specifically developed to help adults 18 and over quit smoking. It targets nicotine receptors in the brain, attaches to them, and blocks nicotine from reaching them.  Based on the observed smoking abstinence outcomes, researchers found that data obtained in real-world behavioral therapy settings are comparable to those from the varenicline phase III clinical trials. Gastrointestinal disturbances and abnormal dreams were the most likely varenicline side effects, similar to the proportion of study participants reporting side effects in the phase III trials.  No serious neuro-psychiatric incidents attributable to varenicline use occurred during the trial.

Coauthors were Jennifer B. McClure, PhD, Lisa M. Ja
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SOURCE SRI International
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