Navigation Links
Research Evaluating Effectiveness of Behavioral Counseling and Varenicline for Smoking Cessation Featured in the American Journal of Preventive Medicine

MENLO PARK, Calif., May 18 /PRNewswire/ -- A recently completed randomized trial compared three ways to deliver a behavioral smoking cessation program using varenicline (Chantix®): by phone, web, or both.  Although phone counseling had greater treatment advantage for early cessation and appeared to increase medication adherence, no differences in abstinence outcomes were seen at six months. The findings suggest the three programs are all effective treatment options when combined with varenicline.  Nonprofit scientific research institute SRI International, Group Health Research Institute, and Free & Clear, Inc. conducted the trial, which was published in the May 2010 American Journal of Preventive Medicine.

Proactive telephone behavioral counseling (PTC) and web-based services are popular tools for smoking cessation. Although both PTC and web-based services are known to be effective, previous studies have not examined whether a combination of these services results in better outcomes than one method alone.  The trial aimed to determine the relative effectiveness of a widely used smoking cessation program (Free & Clear Quit For Life® Program) that was delivered in three ways: standard PTC, web-based delivery, and a program that combined the two.

The trial was one of the first "real-world" examinations of varenicline use since the original phase III studies sponsored by the manufacturer. The researchers tracked more than 1,200 Group Health adult patients who received behavioral therapy and varenicline to quit smoking. All participants received 12 weeks of varenicline, printed guides, a 5-10 minute orientation call, and access to a toll-free phone number for support as needed.

"Our findings provide important data regarding the real-world use of varenicline and show that a supportive treatment philosophy along with individualized information matter most for long-term smoking cessation success," said Gary Swan, Ph.D., director of the Center for Health Sciences at SRI International and lead author of the study. "Any of the programs show promise as a counseling tool when used in combination with varenicline."

Varenicline is a non-nicotine prescription medicine specifically developed to help adults 18 and over quit smoking. It targets nicotine receptors in the brain, attaches to them, and blocks nicotine from reaching them.  Based on the observed smoking abstinence outcomes, researchers found that data obtained in real-world behavioral therapy settings are comparable to those from the varenicline phase III clinical trials. Gastrointestinal disturbances and abnormal dreams were the most likely varenicline side effects, similar to the proportion of study participants reporting side effects in the phase III trials.  No serious neuro-psychiatric incidents attributable to varenicline use occurred during the trial.

Coauthors were Jennifer B. McClure, PhD, Lisa M. Jack, MA, Susan M. Zbikowski, PhD, Harold S. Javitz, PhD, Sheryl L. Catz, PhD, Mona Deprey, MS, Julie Richards, MPH, and Timothy A. McAfee, MD, MPH.

The project described is registered at (NCT00301145). It was 97.85 % funded ($3.3 M) by the National Cancer Institute (Grant R01CA071358). Pfizer Inc. provided study medication and nominal support (2.15%) for recruiting participants ($72K).

About SRI International

Silicon Valley-based SRI International is one of the world's leading independent research and technology development organizations. SRI, which was founded by Stanford University as Stanford Research Institute in 1946 and became independent in 1970, has been meeting the strategic needs of clients and partners for more than 60 years. Perhaps best known for its invention of the computer mouse and interactive computing, SRI has also been responsible for major advances in networking and communications, robotics, drug discovery and development, advanced materials, atmospheric research, education research, economic development, national security, and more. The nonprofit institute performs sponsored research and development for government agencies, businesses, and foundations. SRI also licenses its technologies, forms strategic alliances, and creates spin-off companies. In 2009, SRI's consolidated revenues, including its wholly owned for-profit subsidiary, Sarnoff Corporation, were approximately $470 million.

Group Health Research Institute

Founded in 1947, Group Health Cooperative is a Seattle-based, consumer-governed, nonprofit health care system. Group Health Research Institute changed its name from Group Health Center for Health Studies in 2009. Since 1983, the Institute has conducted nonproprietary public-interest research on preventing, diagnosing, and treating major health problems. Government and private research grants provide its main funding.

About Free & Clear, Inc.

Free & Clear, a wholly owned subsidiary of Alere LLC and its parent company, Inverness Medical Innovations, is a healthy behaviors company specializing in phone-based cognitive behavioral coaching, web-based e-learning, and training and technical assistance.  Free & Clear's evidence-based programs address the four key modifiable health risks that contribute to chronic disease: tobacco use, poor nutrition, physical inactivity and stress. Free & Clear's tobacco cessation program evolved 25 years ago out of research funded by the National Cancer Institute to test the effectiveness of telephonic smoking cessation treatment. Since that time Free & Clear has established itself as the national leader in tobacco dependence treatment.   Free & Clear is  committed to the advancement of the science of tobacco prevention and cessation. We have conducted more than 20 clinical trials and contributed to more than 100 peer-reviewed scientific publications.

SOURCE SRI International
Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. Turning the Page in HIV Prevention Research: An AIDS Vaccine is Possible — AVAC Examines The Way Forward
2. Xenon Announces Appointment of EVP, Research & Development
3. Watson to Present at the 2010 Citi Investment Research Global Healthcare Conference
4. CVS Caremark to Participate in the Citi Investment Research 2010 Food & Drug Retail Conference
5. SRI International Researchers Present Promising New Therapeutic for the Treatment of Multiple Myeloma
6. DNA Medicine Institute Receives $100,000 Grand Challenges Explorations Grant for Innovative Global Health Research
7. Alexza Pharmaceuticals to Present at The Ninth Annual JMP Securities Research Conference
8. ISTA Pharmaceuticals to Present at the Ninth Annual JMP Securities Research Conference
9. Cystic Fibrosis Foundation Launches National Cycling Series to Benefit Critical Research and Care
10. Kensey Nash to Present at the Ninth Annual JMP Securities Research Conference
11. Data From LigoCytes Clinical Studies of Norovirus VLP Vaccine Presented at 13th Annual Conference on Vaccine Research
Post Your Comments:
(Date:11/26/2015)... Nov. 26, 2015 Research and Markets ... the "2016 Future Horizons and Growth Strategies ... Supplier Shares, Country Segment Forecasts, Competitive Intelligence, Emerging ... --> --> This ... the Italian therapeutic drug monitoring market, including emerging ...
(Date:11/26/2015)... DUBLIN , November 26, 2015 ... has announced the addition of the  ... in the European Cell Surface Marker ... Emerging Opportunities"  report to their offering.  ... announced the addition of the  "2016 ...
(Date:11/25/2015)... -- The total global healthcare industry is expected to grow at ... America has the highest projected growth at 12.7%, ... ), is second with growth projected at 11.5%. ... expenditure. In 2013-2014, total government funded healthcare was nearly 68%. ... 41.2% in 2013-2014. In real terms, out of pocket expenditure ...
Breaking Medicine Technology:
(Date:11/27/2015)... ... 2015 , ... The print component of “Supporting Our Caregivers” ... New York, Minneapolis, South Florida, with a circulation of approximately 250,000 copies and ... vast social media strategy and across a network of top news sites and ...
(Date:11/27/2015)... ... 2015 , ... A simply groundbreaking television series, "Voices in America", which is ... an array of issues that are presently affecting Americans. Dedicated to providing the world ... is changing the subjects consumers focus on, one episode at a time. , ...
(Date:11/27/2015)... Rosa, CA (PRWEB) , ... November 27, 2015 , ... ... Northern California Medical Associates, Inc. and Dr. Tucker Bierbaum with Emergency Medicine at ... meeting. They observed that both STEMI and Sepsis conditions present in similar ways and ...
(Date:11/26/2015)... ON (PRWEB) , ... November 26, 2015 , ... ... of a real-time eReferral system for diagnostic imaging in the Waterloo region. Using ... BMD and Nuclear Medicine tests directly from their electronic medical record (EMR) without ...
(Date:11/26/2015)... ... November 26, 2015 , ... ... process, participated in the 61st annual Employee Benefits Conference. The Employee Benefits Conference ... Sunday, November 8th through Wednesday, November 11th, 2015. The conference was held at ...
Breaking Medicine News(10 mins):