Navigation Links
Reprogrammable Cell Type Depends on a Single Gene to Keep Its Identity
Date:12/1/2008

traps and attacks invading organisms and is a primary route for malignant tumor dissemination to the regional lymph nodes.

"The new finding adds to a growing body of evidence showing that some fully differentiated cell types can exhibit great plasticity and upon reprogramming revert back to their previous identity," said Guillermo Oliver, Ph.D., a member of the St. Jude Department of Genetics and Tumor Cell Biology. Differentiation is the process by which genetic activity causes an immature cell type to acquire specific characteristics of a particular mature adult cell type.

"In the last few years, some discoveries have challenged the long-standing belief that cell differentiation is an irreversible final process," said Oliver, the paper's senior author. "St. Jude researchers showed that lymphatic endothelial cells are one of the few examples of differentiated cell types that require constant expression of a specific gene to maintain their identity. This current work builds on our previous results that demonstrated the key role Prox1 plays in the formation of the lymphatic vasculature."

As an important resource for this finding, Oliver's team used a special mouse strain in which the Prox1 genes could be deleted from LECs at different times during development or after birth.

The St. Jude team found that deletion of Prox1 in LECs promoted their reprogramming into BECs as indicated by the expression of specific LEC and BEC proteins. In addition, the newly reprogrammed cells gained some specific features typical of blood vessels. For example, the cells were surrounded by pericytes -- small cells that help support endothelial cells -- and blood abnormally entered the reprogrammed mutant lymphatic vessels.

Finally, the researchers used a trick that enabled them to block the ability of isolated cultured LECs to produce the Prox1 proteins to fur
'/>"/>

SOURCE St. Jude Children's Research Hospital
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Pharmasset Presents R7128 Phase 1 Single Ascending Dose Study in Healthy Volunteers
2. Survival Data in FDA Approval for ERBITUX(R) (Cetuximab) Supports use as a Single Agent in Patients with Advanced Colorectal Cancer
3. Health Canada Approves ATRIPLA(R) (efavirenz 600 mg/emtricitabine 200 mg/ tenofovir disoproxil fumarate 300 mg), the First Once-Daily Single Tablet Regimen for HIV
4. Data Presented at 2007 ASH Meeting Demonstrate Activity of Forodesine HCl as a Single Agent or in Combination With Bendamustine in Certain Types of Leukemia and Lymphoma
5. European Commission Approves ATRIPLA(R) (efavirenz 600 mg/emtricitabine 200 mg/tenofovir disoproxil fumarate 300 mg), the First Once-Daily Single Tablet Regimen for Virologically Suppressed Adults With HIV-1 Infection
6. HealthMedias Strongest Single Quarter Results: Growth Driven by Product Enhancements, New Partnerships
7. Sunesis Pharmaceuticals Reports Positive Interim Data for SNS-595 Single-Agent Activity in Platinum-Resistant Ovarian Cancer
8. Lotrel, a Single-Pill Combination for Treating High Blood Pressure, Reduced Cardiovascular Events by 20% in High-Risk Patients
9. RICE MEMORIAL HOSPITAL PHARMACY STAFF EXPERIENCES A 55% REDUCTION IN TIME SPENT MANAGING PATIENT-SPECIFIC MEDICATIONS USING OMNICELL SINGLEPOINTE SOLUTION
10. Novare Announces Completion of First Pediatric Single Port Spleen Removal Using RealHand(R) HD Instruments
11. Novare Announces Successful Series of Single Port Lap Band Procedures With RealHand(R) High Dexterity Instruments
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... MUMBAI, India , July 11, 2014 /PRNewswire/ ... the treatment of cancer are being highlighted in ... Mumbai from 10-12 July, 2014.  Renowned ... meeting to share best practices and exchange knowledge ... more precise, accurate and efficient. ...
(Date:7/10/2014)... , July 10, 2014  The U.S. Department ... three-year grant to University Hospitals (UH) Case Medical Center ... new national model aimed at improving care for patients ... Care," the project will test a unique model developed ... with late-stage disease, significant comorbidities, or demonstrated need for ...
(Date:7/10/2014)... 10, 2014 Integrated Silicon Solution, Inc. (Nasdaq: ... and analog IC solutions, today announced that it will ... 2014, at 7:00 a.m. Pacific Time (10:00 a.m. Eastern ... fiscal 2014 third quarter ended June 30, 2014. ... 1-888-556-4997 before 6:50 a.m. Pacific time on July 24, ...
Breaking Medicine Technology:Improving quality and access to advanced cancer care in India and South Asia 2Improving quality and access to advanced cancer care in India and South Asia 3Improving quality and access to advanced cancer care in India and South Asia 4Improving quality and access to advanced cancer care in India and South Asia 5University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 2University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 3University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 4
(Date:7/13/2014)... New York (PRWEB) July 13, 2014 ... ( http://www.transvaginalmeshlawsuithelp.com/ ) filed against Johnson & ... second bellwether trial, which is expected to get underway ... issued in the U.S. District Court, Southern District of ... will be held on August 7, 2014 at 3:00 ...
(Date:7/13/2014)... (PRWEB) July 13, 2014 Fadhits.com is ... sexy prom dresses are extremely beautiful. Recently, the company ... dresses for 2014. What’s more, all these outfits ... percent off). , Additionally, the supplier is now ... with elegant Quinceanera dresses, it has many other designs ...
(Date:7/13/2014)... According to the Kidney Disease Solution book review recently ... on what to do to eliminate the root cause ... its review that readers can easily learn what foods to ... health. Vkool also informs in its Kidney Disease Solution review ... functions naturally. The book consists of a collection of natural ...
(Date:7/13/2014)... ECS is being founded by Seattle ... a special needs child, I have become keenly aware ... contemporary special education resources and evidence-based instruction. Emerald City ... families in the Seattle metro area that are looking ... We welcome the opportunity to serve our community and ...
(Date:7/13/2014)... Seattle, Wa (PRWEB) July 13, 2014 ... updated by Vkool.com, this is a comprehensive guide that ... to deal with KP (keratosis pilaris). This ...     Chapter 1: What Is Keratosis Pilaris? ,     Chapter ... Do I Know If I Have KP? , ...
Breaking Medicine News(10 mins):Health News:Ethicon Vaginal Mesh Lawsuits Move Forward, As Federal Court Schedules Pretrial Conference for Second Bellwether Case, Bernstein Liebhard LLP Reports 2Health News:Ethicon Vaginal Mesh Lawsuits Move Forward, As Federal Court Schedules Pretrial Conference for Second Bellwether Case, Bernstein Liebhard LLP Reports 3Health News:Ethicon Vaginal Mesh Lawsuits Move Forward, As Federal Court Schedules Pretrial Conference for Second Bellwether Case, Bernstein Liebhard LLP Reports 4Health News:Fadhits.com Announces a Special Offer on Elegant Quinceanera Dresses 2Health News:Kidney Disease Solution Book Review Exposes Duncan Capicchiano's Newly Updated Kidney Disease Treatment Plan – Vkool.com 2Health News:Kidney Disease Solution Book Review Exposes Duncan Capicchiano's Newly Updated Kidney Disease Treatment Plan – Vkool.com 3Health News:New Private School, Emerald City School, Founded in Downtown Seattle Now Accepting 1st to 6th Grade Students Who Learn Differently 2Health News:Living With KP Book Review Exposes Jennifer Richards' Keratosis Pilaris Guide – Vkool.com 2Health News:Living With KP Book Review Exposes Jennifer Richards' Keratosis Pilaris Guide – Vkool.com 3
... back by medical advances in the mid-20th century, is making ... increasingly resistant to treatment, infecting and killing more people than ... year, according to estimates by the U.S. Agency for International ... many as 2.7 million by some estimates -- of those ...
... who are male and over age 34 are at the ... stress the importance of discontinuing drug-use among older drug users.// ... define different sectors to help them. A study conducted by ... at the greatest risk of death. Researchers looked at the ...
... mixes the conventional seed with a bright-blooming relative offers the ... ,Corn oil and other food products with this heart-healthy ... the world within four years. The breakthrough after ... other healthy varieties such as popcorn and yellow sweet corn. ...
... American teenage girls are more likely to use indoor tanning ... a Case Western Reserve University study.// ,The study found ... indoor tanning facility at least once, and nearly 30 percent ... times. ,The percentage of girls using tanning booths increased ...
... stores are removing thousands of jars of pasta sauces because ... shoe polish.// ,Sky News said consumers are being warned ... private-label sauces made for supermarket chains Sainsbury's and Safeway. ... called Sudan 1 in chili powder used in the sauces. ...
... in broken bones among adolescents has alarmed researchers who say ... ,Researchers at the Mayo Clinic in Rochester, Minnesota, examined data ... between 1999 and 2001. They found that the incidence of ... the increase was among young people under 20., ,Sundeep ...
Cached Medicine News:Health News:The 'forgotten epidemic' killing millions 2Health News:New heart-healthy corn due in stores by 2007 2Health News:,Girls Hit Tanning Booths More Than Boys 2Health News:Teens break bones 'due to lack of milk' 2
The Benchmark Microplate Reader, with its increased wavelength range of 340 to 750 nm and high performance optics, provides flexibility for specialized applications requiring increased linearity, ult...
Elisa strip reader...
Iems Incubator/Shaker expansion module for 2 module incubator/shaker. high performance microplate incubator and orbital shaker. It's superior temperature control and efficient orbital shaking reduce ...
... Millennium 2000 is a unique microprocessor controlled ... microplates in either 96 or 384 well ... via the control panel and all are ... visible under the clear protective cover. The ...
Medicine Products: