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Reportlinker Adds Transdermal Drug Delivery - Technologies, Markets, and Companies

NEW YORK, Sept. 7 /PRNewswire/ -- announces that a new market research report is available in its catalogue:

Transdermal Drug Delivery - Technologies, Markets, and Companies

Benefits of this report

* Up-to-date one-stop information on transdermal drug delivery

* Description of 117 companies involved and 100 collaborations in this area

* Market analysis 2009-2019/

* Market values in major regions

* Strategies for developing markets for transdermal drug delivery

* A selected bibliography of 170 publications

* Text is supplemented by 17 tables and 10 figures

Who should read this report?

* Biotechnology companies developing transdermal technologies

* Drug delivery companies

* Pharmaceutical companies interested in transdermal drug delivery

* Pharmaceutical research institutes


This report deals with transdermal drug delivery - an approach used to deliver drugs through the skin for therapeutic use as an alternative to oral,intravascular, subcutaneous and transmucosal routes. Various transdermal drug delivery technologies are described including the use of suitable formulations, carriers and penetration enhancers. The most commonly used transdermal system is the skin patch using various types of technologies. Nanoparticles as well as the use of physical agents to facilitate transcutaneous drug delivery is described. Microneedle and needleless technologies are also described. Transdermal technologies may be applied for several categories of pharmaceuticals used for the treatment of disorders of the skin or for systemic effect to treat diseases of other organs. Several transdermal products and applications include hormone replacement therapy, contraception, management of pain, angina pectoris, smoking cessation and neurological disorders such as Parkinson's disease. The market for transdermal drug delivery is analyzed according to technologies and therapeutic areas from 2009 to 2019. This market is analyzed according to geographical regions as well.


0.Executive Summary11

1.Basics of Transdermal Drug Delivery13


Historical landmarks in transdermal drug delivery13

Anatomy and physiology of skin14

Transcutaneous absorption14

Transdermal versus other methods of drug delivery14

Advantages of transdermal drug delivery15

First-Pass Effect15

Drawbacks of transdermal delivery15

Factors that influence transdermal drug delivery15

Events governing transcutaneous absorption16

Properties of the skin16

Properties of drugs17

The role of pH and pharmacokinetics17

Intradermal disposition of drugs after topical application18

2.Transdermal Drug Delivery Technologies19


Local application formulations20

Crystalline topical formulations20

Microemulsions for transdermal drug delivery20

Transdermal gel technology21

Film forming polymeric solutions22

Biphasix system22

Penetration enhancers23

Chemical enhancers23

Nitric oxide-based transdermal drug delivery25

Vesicular transdermal carriers25




Elastic vesicles for transdermal drug delivery27

Nanovesicles for transdermal drug delivery27

Transdermal patches28

Adhesives for transdermal patches29

Commercial development of transdermal patches29

Innovations in transdermal patches30

e-Patch™ controlled release micropump system30

Patchless Transdermal Delivery System31

Metered-dose transdermal system31

Use of physical modalities to facilitate transdermal transport32

Transdermal electrotransport32


Drug delivery by electroporation33



Iontophoresis compared with electrophoresis36

Application of iontophoresis for drug delivery36

Companies with technologies for drug delivery by iontophoresis37

Combination of electrophoresis and iontophoresis38


Radiofrequency-driven transdermal delivery38


Transcutaneous drug delivery by electropulsation39

Companies involved in electroporation-based drug delivery40

Electrode Scanning System40

Use of electrostatic force in skin patch technology40

Multiple Absorption Kinetic System41

Transdermal drug delivery facilitated by heat41

Controlled, heat-aided drug delivery41



Use of lasers for transdermal drug delivery43

Transdermal drug delivery by laser-induced pressure waves43

Transdermal drug delivery by laser-assisted changes in skin44

Transdermal delivery by gas under pressure45

Transdermal delivery with PowderJect gas gun45

Microscission induced by gas45

Microneedles and dermal microinjection technologies45

Microneedle patch45

Microneedle arrays for drug delivery46

MicroPyramid™ hollow microneedles47

Microstructured Transdermal Systems47

Microneedle Array Patch technology47

Macroflux microprojections technology48

Companies developing microneedles for transdermal drug delivery48

Needlefree injections48

Glide SDI® solid dose injector48

Jet injection49

Mini-Ject needlefree delivery system49

MicroJet for painless injections49

Nanoliter-volume pulsed microjets50

SUMAVEL™ DosePro™ needle-less injection50

Skin ablation or abrasion for drug delivery50

Nanotechnology-based transdermal drug delivery51

Nanoparticles and nanoemulsions for skin disorders51

Transdermal nanoparticle preparations for systemic effect51

Nanotechnology-based transdermal vaccination and immunotherapy52

Delivery of nanostructured drugs from transdermal patches53

NanoCyte transdermal drug delivery system53

Effect of mechanical flexion on penetration of bucky balls through the skin53

Safety issues of applications of nanomaterial carriers on the skin53

Comparison of transdermal drug delivery systems54

Role of microelectronics in transdermal drug delivery54

Transdermal drug design54

In vitro testing of transdermal drug delivery systems55

In vivo testing of drug delivery systems56

Infrared spectroscopy for evaluation of transdermal drug delivery56

Modeling of transport through the skin56

Concluding remarks on transdermal drug delivery technologies57

Future developments in transdermal drug delivery58

3.Transdermal Therapeutics59


Drugs that can be administered transdermally59

Skin disorders62

Fungus infections of nails62

Topical penetrating applications for nail fungus infections62

Hair loss62

Cardiovascular disorders62

Angina pectoris62

Transdermal drug delivery for hypertension64

Transdermal beta blockers64

Transdermal anticoagulants64

Congestive heart failure65

Respiratory diseases65


Chronic obstructive pulmonary disease66

Neurological and psychiatric disorders66

Parkinson's disease66

Transdermal drug delivery for Parkinson's disease67

Transdermal dopamine agonists for Parkinson's disease67


Transdermal administration of other drugs for Parkinson's disease69


Transdermal selegiline69

Bipolar disorder70

Transdermal lithium70

Restless legs syndrome70

Alzheimer's disease71

Transdermal nicotine for Tourette syndrome71

Attention deficit hyperactivity disorder71

Transdermal methylphenidate71


Transdermal lidocaine72

Transdermal sumatriptan72



Transdermal nitroglycerin for vasospasm due to subarachnoid hemorrhage73

Musculoskeletal disorders73


Transdermal hormonal therapy74


Transdermal insulin delivery in diabetes74

Male sexual disorders75

Erectile dysfunction75

Topical and transdermal preparation for erectile dysfunction76

Hypogonadism in the male76

Topical testosterone77

Women's health78

Female sexual arousal disorder78


Hormone replacement therapy for menopause79

Effect of transdermal estradiol on bone density81

Transdermal testosterone for low libido in postmenopausal women81

Breast disorders81



Female contraception82

Ortho Evra™82


Male contraception83

Transdermal progestin plus testosterone83


Transcutaneous electroporation for anticancer drugs84

Transdermal nitroglycerine for prostate cancer84


Relief of pain associated with minor medical procedures85

Transdermal Lidoderm? for postherpectic neuralgia85

Nonsteroidal antiinflammatory drugs86

Topical NSAIDs86

Transdermal ketoprofen87

Topical opioids88

Cancer pain88

Transdermal fentanyl88

Transdermal nitroglycerine as an adjuvant to opioids89

Transdermal buprenorphine89

Chronic pain of non-malignant origin90

Postoperative pain90

Transdermal fentanyl for the management of postoperative pain90


Nausea and vomiting91

Motion sickness91

Postoperative vomiting91

Chemotherapy-induced nausea and vomiting91

Antiaging strategies91

Smoking cessation92

Transdermal nicotine replacement92

Other methods of nicotine replacement93

Other treatments for smoking cessation93

Miscellaneous uses of transdermal drug delivery94

Chronic fatigue syndrome94

Topical androgenic steroid therapy94

Overactive bladder and urinary incontinence94

Transdermal oxybutynin94

Viral infections95

Transdermal nanoparticles for immune enhancement in HIV95

Transdermal gene therapy95

Transdermal delivery of plasmid DNA by electroporation96

Transdermal antisense therapy96

Transdermal vaccination97

The skin as an immune organ97

Technologies for transdermal vaccination97

Dermal microinjection technology for delivery of vaccines97

Electroporation for administering DNA vaccines97

Intradermal delivery of cancer vaccines by adenoviral vectors98

Needle free delivery of vaccines98

Transcutaneous immunization99

Applications of transdermal vaccination99

HIV/AIDS vaccination by topical application99

Transdermal DNA influenza vaccine100

Transdermal A? vaccination for Alzheimer's disease100

Transdermal vaccination for traveller's diarrhoea100

Transdermal neutraceuticals101

Complications of transdermal therapy101

Adverse effects of drugs101

Overdose effect102

Skin complications102

4.Markets for Transdermal Drug Delivery103


Global markets for drug delivery103

Geographical distribution of transdermal drug delivery markets104

Emerging transdermal drug delivery markets in Asia104

Transdermal technology markets in therapeutic areas104

Angina pectoris105

Attention deficit hyperactivity disorder105

Erectile dysfunction105


Pain therapeutics106

Parkinson's disease106

Smoking cessation106

Transdermal hormone replacement therapy for menopause106

Transdermal testosterone replacement therapy for hypogonadism in the male107

Transdermal contraceptive market107

Markets according to transdermal technologies107

Marketing strategies for transdermal drug delivery107

Marketing advantages of transdermal drug delivery108

Unmet needs in transdermal drug delivery109

Future prospects of transdermal drug delivery110

Prospects of transdermal delivery for drugs coming off patents110

Transdermal delivery of cosmetics110

5.Companies involved in transdermal drug delivery111

Profiles of companies111




Table 1 1: Historical landmarks in the development of transdermal drug delivery13

Table 1 2: Transdermal vs oral and intravenous drug delivery15

Table 2 1: Technologies for transdermal drug delivery19

Table 2 2: Chemical enhancers of skin penetration23

Table 2 3: Drug-in-adhesive versus reservoir type of transdermal patch28

Table 2 4: Companies developing transdermal patches for drug delivery29

Table 2 5: Companies with technologies for drug delivery by iontophoresis37

Table 2 6: Companies involved in electroporation-based drug delivery40

Table 2 7: Companies developing microneedles for transdermal drug delivery48

Table 2 8: Comparison of transdermal drug delivery systems54

Table 3 1: Approved categories of transdermal drugs59

Table 3 2: Current status of transdermal products60

Table 4 1: Worldwide drug delivery market growth 2009 to 2019103

Table 4 2: Transdermal drug delivery markets for geographical regions 2009 to 2019104

Table 4 3: Potential therapeutic markets for transdermal products 2009-2019105

Table 4 4: Marketing strategies based on transdermal drug delivery technologies108

Table 5 1: Collaborations in transdermal drug delivery232


Figure 1 1: Basic structure of the skin14

Figure 1 2: Events governing transcutaneous drug absorption 17

Figure 2 1: Basic structure and function of transdermal drug delivery systems28

Figure 2 2: A schematic view of electroporation33

Figure 2 3: Depiction of breakdown of the stratum corneum during electroporation34

Figure 2 4: A schematic drawing of Iontophoresis35

Figure 2 5: SonoPrep ultrasonic skin permeation42

Figure 2 6: A schematic drawing of the microneedle patch46

Figure 3 1: Oral versus transdermal administration of a drug in Parkinson's disease68

Figure 4 1: Unmet needs in transdermal drug delivery109

To order this report:

Drug Delivery Technology Industry: Transdermal Drug Delivery - Technologies, Markets, and Companies

Drug Delivery Technology Business News

More  Market Research Report

Check our  Company Profile, SWOT and Revenue Analysis!

Nicolas Bombourg



US: 805-652-2626

Intl: +1 805-652-2626

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