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Reportlinker Adds Threats to Avastin - Targeting the VEGF Pathway
Date:8/31/2010

otrient/Armala are all multi-kinase inhibitors and Pfizer's Torisel and Novartis' Afinitor are mTOR (kinase) inhibitors.

Looking forward...

Drugs with novel mechanisms of inhibiting angiogenesis are beginning to emerge in company pipelines. Espicom has identified 13 major projects in Phase III development, with a further 10 in Phase II. Novel agents include:

Enzastaurin: A novel agent that acts through inhibition of protein kinase C and has been found to suppress tumour growth through multiple mechanisms, such as the direct suppression of tumour cell proliferation.

Panobinostat: This pan-histone deacetylase inhibitor targets multiple oncogenic pathways, including angiogenesis.

PF-02341066: This is a selective ATP-competitive small-molecule inhibitor of both c-Met/hepatocyte growth factor receptor and anaplastic lymphoma kinase tyrosine kinases and their oncogenic variants.

With this report you will...

Understand Avastin's unique position in the oncology market

Evaluate its strengths and weaknesses relative to other VEGF-targeting products

Gain insight into the prevalence of cancers in Avastin's therapeutic window

Review the merits of 21 late-phase development prospects with Espicom's unique 5-point competitive assessment

Know the launch timeframe for up and coming products

Estimate future revenues with 5-year forecasts for more than 20 launched and late-phase products

Just some of the approaches being used by products in this report

VEGFr-1, -2 and -3 tyrosine kinase inhibitors

VEGF Trap

MET & RET inhibitors

PDGFr inhibitors

HDAC inhibitors

Questions answered by the report include...

Which other products in the pipeline mirror Avastin's therapeutic approach?

What are the extension indications Avastin is expected to secure to 2016?

In 2012, five products targeting the VEGF pathway are expected to lau
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SOURCE Reportlinker
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