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Reportlinker Adds Successful Strategies for Drug Repositioning
Date:4/20/2011

NEW YORK, April 20, 2011 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue:

Successful Strategies for Drug Repositioning

http://www.reportlinker.com/p0483598/Successful-Strategies-for-Drug-Repositioning.html

Introduction

This report Highlights how drug repositioning can provide a low-risk approach to drug development. The success of the approach is illustrated by a number of case histories, mostly arising from serendipitous observations. The report illustrates systematic approaches to identify suitable opportunities that should lead to better success including those being pursued by specialist companies.

Features and benefits

* Analyze and understand the strategies employed in the most successful examples of drug repositioning.

* Discover the key technologies required to establish potential repositioning opportunities.

* Identify the specialist service providers with expertise in the key technologies required to systematically identify repositioning candidates.

* Discover how through repositioning a company can protect its intellectual property.

* Analyze the potential impact that drug repositioning can have on both large pharma companies and small specialist companies.

Highlights

The pharma industry's revenue growth is low and it is failing to introduce sufficient new drugs to offset the impact of patent expirations despite record R&D costs. Repurposing of drugs offers a lower risk, lower cost, approach to new product development. Repurposing of development failures can recover what would otherwise be lost R&D expenditure.

The potential commercial benefits from successful repositioning of a drug are likely to be greater than those offered by simple reformulation, and offers opportunities for extended periods of market exclusivity via the granting of additional patents.

Major companies are well positioned to benefit from the successful repurposing of drugs, especially when they utilize both internal resources and external resources. The effective application of repurposing technologies should enable major companies to significantly enhance their development pipelines.

Your key questions answered

* What are the current advantages of repositioning over other lower risk approaches to drug development?

* What are the key technologies being used to identify new targets for molecules in companies' databases?

* How does drug repositioning improve the intellectual property position of companies that employ this strategy?

* What skills and platforms do specialist companies engaged in drug repositioning possess?

* How have molecules such as sildenafil and thalidomide been repositioned successfully?

TABLE OF CONTENTS

Executive Summary

Chapter 1 Introduction

Chapter 2 Lower Risk Strategies

Chapter 3 What is Repositioning?

Chapter 4 Strategic Approaches to Repositioning

Chapter 5 Successful case studies

Chapter 6 Current Efforts

Chapter 7 Specialist Companies

Chapter 8 Outlook

About the author

Disclaimer

Introduction

Summary

Introduction

The decline in approvals of novel chemical entities

The costs, and risks, of drug development

Lower Risk Strategies

Summary

Introduction

Enantiomeric switches

Active metabolites

Reformulation

Repositioning

What is Repositioning?

Summary

Overview

Commercial implications

Intellectual property issues

Design or serendipity?

Strategic Approaches to Repositioning

Summary

Introduction

Chemical space

New indications

Phenotypic approaches

Informatics-based approaches

Reformulation

Exploiting intellectual property

Increased licensing opportunities

Successful case studies

Summary

Introduction

Bupropion

Minoxidil

Thalidomide

Bosentan

sildenafil (Viagra and Revatio)

Current Efforts

Summary

Introduction

Major opportunities

Rare diseases

Drugs in advanced development

Inhaled formulations

Biological products

Modified formulations

Repurposing by combination

Other approaches

Specialist Companies

Summary

Introduction

Almac Group

Ampio Pharmaceuticals

Anaxomics Biotech

APT Pharmaceuticals

Aureus Sciences

Biovista

Celentyx

Cypress Bioscience

Essentialis

Horizon Discovery

Jenken Biosciences

Melior Discovery

NeuroHealing Pharmaceuticals

Numedicus

OphSmart

Optimata

Ore Pharmaceutical Holdings

Radical Therapeutix

SOM Biotech

Somaxon Pharmaceuticals

Sosei Group

SWITCH Biotech

Tangent Reprofiling

Zalicus

Outlook

Summary

Introduction

Impact on major companies

Impact for specialist companies

Overall perspective

Appendix

Glossary/Abbreviations

Bibliography/References

To order this report:

: Successful Strategies for Drug Repositioning

More  Market Research Report

Check our  Company Profile, SWOT and Revenue Analysis!

Nicolas Bombourg

Reportlinker

Email: nbo@reportlinker.com

US: (805)652-2626

Intl: +1 805-652-2626


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