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Reportlinker Adds RNAi Drug Delivery: Technologies and Global Markets
Date:3/24/2011

LEXES AND RNAI DELIVERY 62

Case Study-siRNA in Mammalian Cells 62

Gene Silencing (RNAi) in Neuronal Cells 62

Concerns about RNAi Delivery 63

KEY COMPANIES 63

siRNA Transfection 63

   TABLE 13 COMPANIES INVOLVED IN DRUG DELIVERY TECHNOLOGIES FOR SIRNA 64

Delivery as Particles or Complexes 65

Delivery with Modifications 65

SUMMARY 66

Summary (Continued) 67

Chapter-5: RNAI-BASED THERAPEUTICS

RNAI-BASED THERAPEUTICS: THE EMERGING INDUSTRY LANDSCAPE 68

DELIVERING RNAI THERAPEUTICS 69

Delivering RNAi Therapeutics (Continued) 70

RNAi and Cancer Therapeutics 71

REGULATORY CONCERNS 71

Regulatory Concerns (Continued) 72

RNAI IN CLINICAL TRIALS 73

Clinical RNAi Pipeline 73

   TABLE 14 THE GLOBAL RNA INTERFERENCE THERAPEUTIC PIPELINE 73

   TABLE 14 (CONTINUED) 74

Clinical RNAi Pipeline (Continued) 75

Clinical RNAi Pipeline (Continued) 76

THE MOST ADVANCED RNAI CANDIDATE 77

Alnylam's ALN-RSV: Respiratory Syncytial Virus 77

ALN-RSV01 Treatment of Respiratory Syncytial Virus Infection in Lung Transplant Patients 78

THERAPEUTIC RNAI-RECENT DEVELOPMENTS 79

Case Study-ALN-VSP02 79

Case Study-ALN-VSP02 (Continued) 80

SNALP Delivery 81

Other Candidates in Clinical Trials 82

Other Candidates in Clinical … (Continued) 83

Unexpected Problems and Possible Solutions for RNAi-Based Therapies 84

Unexpected Problems and … (Continued) 85

Chapter-6: RNAI LANDSCAPE

FUTURE TRENDS 86

WHAT IS RNA INTERFERENCE? 87

Locked Nucleic Acid 87

RNAI AS A RESEARCH TOOL 87

THE IMPORTANCE OF RNAI DESIGN 88

FACTS AND TIMELINES 88

MARKET GROWTH 89

GLOBAL MARKET FOR RNAI 89

   TABLE 15 GLOBAL RNAI RESEARCH SALES AND FORECAST, THR
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