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Reportlinker Adds RNAi Drug Delivery: Technologies and Global Markets
Date:3/24/2011

TECHNIQUES 36

VECTOR-BASED DELIVERY 36

VECTOR-BASED RNAI FOR IN VIVO RNAI EXPERIMENTS 36

   TABLE 5 COMPANIES WITH PLASMID RNAI VECTORS 37

Viral Vectors for Delivery of siRNA 37

   TABLE 6 RNAI VIRAL VECTOR DELIVERY METHODS 38

   TABLE 7 LENTIVIRAL DELIVERY PRODUCTS AND COMPANIES 38

NONVIRAL SIRNA DELIVERY 38

Hydrodynamic IV Injection 39

Electroporation 39

CARRIER-MEDIATED DELIVERY 39

Lipid-based siRNA Delivery 39

Lipid-based siRNA delivery (Continued) 40

Polymer-Based siRNA Delivery 41

Combined Lipid and Polymer Carriers for a Better siRNA Delivery 42

Peptide-Mediated siRNA Delivery 43

Antibody-Mediated siRNA Delivery 44

Dendrimer-Mediated siRNA Delivery 45

Stem-cell-based Delivery 45

Light Controllable Delivery of siRNA 45

PROPRIETARY DELIVERY PLATFORMS 46

SYSTEMIC DELIVERY STRATEGIES 47

   TABLE 8 THERAPEUTIC STRATEGIES 48

LOCALIZED DELIVERY 48

Targeted Cellular Delivery 49

EXPRESSION-BASED STRATEGIES 50

RNAI DELIVERY AND IMPACT ON THERAPEUTIC DEVELOPMENTS 51

New Developments 52

New Developments (Continued) 53

Tissue Delivery 54

RNAi as Drugs 55

CURRENT NONBIOLOGICAL DELIVERY VEHICLES FOR SIRNAS 56

Simple Excipients 56

   TABLE 9 SIMPLE EXCIEPIENTS FOR RNAI DELIVERY 56

TRANSFECTION TECHNIQUES 57

Electroporation 57

Conjugates 57

   TABLE 10 CONJUGATES, PEPTIDES, AND PROTEINS, OTHERS 57

Peptides and Proteins 58

Dynamic Polyconjugate Transfection 58

Polymer Carriers/Nanoparticles 58

Polymer Carriers/Nanoparticles (Continued) 59

   TABLE 11 POLYMER CARRIERS/NANOPARTICLES FOR RNAI DELIVERY 60

Liposomes and Lipoplexes 61

   TABLE 12 LIPOSOMES/LIPOP
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