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Reportlinker Adds RNAi Drug Delivery: Technologies and Global Markets
Date:3/24/2011

2

RELATED BCC STUDIES 2

ANALYST CREDENTIALS 3

BCC ONLINE SERVICES 3

DISCLAIMER 3

Chapter-2: SUMMARY

SUMMARY 4

    SUMMARY TABLE GLOBAL MARKET FOR RNAI DRUG DELIVERY TECHNOLOGIES, THROUGH 2015 ($ MILLIONS) 5

SUMMARY FIGURE GLOBAL MARKET FOR RNAI DRUG DELIVERY TECHNOLOGIES, 2009–2015 ($ MILLIONS) 6

Chapter-3: OVERVIEW

OVERVIEW 7

THE PROMISE OF RNAI 8

    TABLE 1 VARIOUS TECHNOLOGIES FOR GENE SUPPRESSION 8

RNAI TECHNOLOGY 9

RNAI MECHANISM: -HOW DOES IT WORK? 10

WHY SIRNA THERAPEUTICS? 11

SIRNA DELIVERY 12

RNAI DESIGN AND METHODS 13

Barriers to Delivery 14

Cellular Uptake and siRNAs 15

siRNA Delivery and Challenges 15

COMMERCIAL INTEREST 16

LIPOSOME-BASED DELIVERY 17

NONLIPOSOMAL METHODS 18

Nucleic-Acid Aptamers 18

Aptamers as Therapeutics 19

   TABLE 2 THERAPEUTICALLY TARGETED APTAMERS 19

   TABLE 2 (CONTINUED) 20

Aptamers for siRNA Delivery 21

Challenges-Aptamer-siRNA Delivery 22

Challenges-Aptamer-siRNA … (Continued) 23

Commercial Interest for Aptamers 24

ANTISENSE THERAPY 24

Selected Companies 25

CLASSES OF ENDOGENOUS SMALL RNAS 26

siRNA and rasiRNA 26

siRNA and rasiRNA (Continued) 27

miRNA 28

OUTLOOK 29

Chapter-4: RNAI DRUG DELIVERY

RNAI DISCOVERED 30

IMPORTANCE OF DELIVERY FOR RNAI THERAPEUTICS 31

DRUG DELIVERY TECHNOLOGIES 31

   TABLE 3 ROLE OF DRUG DELIVERY 32

NEED FOR NEW TECHNLOGIES 33

RNAI DELIVERY-TOOL FOR DRUG DISCOVERY AND DEVELOPMENT 33

siRNA Screening 34

shRNA Screening 34

CHALLENGES TO OVERCOME IN DELIVERING RNAI 35

   TABLE 4 DIFFERENT RNAI DELIVERY APPROACHES 35

DIFFERENT DELIVERY
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