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Reportlinker Adds Proteomics - Technologies, Markets and Companies
Date:11/9/2010

rug Actions . 143

ProteomeBinders initiative.. 143

6. Pharmaceutical Applications of Proteomics . 144

Introduction .. 144

Current drug discovery process and its limitations . 144

Role of omics in drug discovery 145

Genomics-based drug discovery 145

Metabolomics technologies for drug discovery . 146 - 7 -

Role of metabonomics in drug discovery 146

Basis of proteomics approach to drug discovery .. 147

Proteins and drug action .. 147

Transcription-aided drug design . 148

Role of proteomic technologies in drug discovery 148

Liquid chromatography-based drug discovery 149

Capture compound mass spectrometry 150

Protein-expression mapping by 2DGE .. 150

Role of MALDI mass spectrometry in drug discovery 150

Tissue imaging mass spectrometry 150

Companies using MALDI for drug discovery 152

Oxford Genome Anatomy Project . 152

Proteins as drug targets .. 153

Ligands to capture the purine binding proteome . 153

Chemical probes to interrogate key protein families for drug discovery 153

Global proteomics for pharmacodynamics . 154

CellCarta® proteomics platform 154

ZeptoMARK protein profiling system 155

Role of proteomics in targeting disease pathways .. 155

Identification of protein kinases as drug targets .. 155

Mechanisms of action of kinase inhibitors 156

G-protein coupled receptors as drug targets . 156

Methods of study of GPCRs.. 157

Cell-based assays for GPCR . 157

Companies involved in GPCR-based drug discovery . 158

GPCR localization database . 159

Matrix metalloproteases as drug targets 159

PDZ proteins as drug targets . 160

Proteasome as drug target . 160

Serine hydrolases as drug targets 161

Targeting mTOR signaling pathway . 161

Targeting caspase-8 for antic
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