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Proteome-scale purification of human proteins from bacteria .. 291
Proteostasis network 292
Cytoproteomics . 292
Subcellular proteomics.. 292
Individual cell proteomics . 293
Live cell proteomics 293
Fluorescent proteins for live-cell imaging 294
Membrane proteomics . 294
Identification of membrane proteins by tandem MS of protein ions . 294
Solid state NMR for study of nanocrystalline membrane proteins . 295
Multiplex proteomics 295
High-throughput for proteomics 295
Future directions for protein biochip application .. 296
Bioinformatics for proteomics 296
High-Throughput Crystallography Consortium .. 296
Study of protein folding by IBM's Blue Gene . 297
Study of proteins by atomic force microscopy .. 297
Population proteomics .. 297
Comparative proteome analysis 298
Human Proteome Organization . 298 - 12 -
Human Salivary Proteome .. 299
Academic-commercial collaborations in proteomics .. 299
Indiana Centers for Applied Protein Sciences 299
Role of proteomics in the healthcare of the future .. 300
Proteomics and molecular medicine . 300
Proteodiagnostics .. 300
Proteomics and personalized medicine 301
Targeting the ubiquitin pathway for personalized therapy of cancer 301
Protein patterns and personalized medicine 301
Personalizing interferon therapy of hepatitis C virus 303
Protein biochips and personalized medicine 303
Combination of diagnostics and therapeutics . 304
Future prospects . 304
12. References . 306
Tables Table 1-1: Landmarks in the evolution of proteomics 18
Table 1-2: Comparison of DNA and protein .. 26
Table 1-3: Comparison of mRNA and protein 26
Table 1-4: Methods of analysis at various levels o
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